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Gene Review

CIR1  -  corepressor interacting with RBPJ, 1

Homo sapiens

Synonyms: CBF1-interacting corepressor, CIR, Corepressor interacting with RBPJ 1, Recepin
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Disease relevance of CIR


Psychiatry related information on CIR

  • This study examined the relationships between observer ratings of interpersonal style (Chart of Interpersonal Reactions in Closed Living Environment [CIR-CLE]) and the personality disorder scales of the Millon Clinical Multiaxial Inventory (MCMI-I) in a sample of male forensic psychiatric inpatients (N = 104) [5].

High impact information on CIR

  • When expressed as a Gal4 fusion protein, CIR repressed reporter gene expression [6].
  • The area under the curve (AUC) of ultrafilterable platinum, average renal clearance (CIR) of ultrafilterable platinum, and percentage of the platinum dose excreted in urine (% E) were determined for each infusion over the 26-hour period of the study [7].
  • In combination with a glucose-independent parameter of beta-cell function (CIR = 100 [8].
  • Budesonide (CIR), a new topically active corticosteroid with very little systemic effects, was at least as effective as prednisolone without producing side effects [1].
  • CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing [9].

Biological context of CIR

  • In this study, CIR, a protein originally identified as a CBF1-interacting protein and reported to act as a transcriptional corepressor, was identified as a PAP-1 binding protein and its function as a splicing factor was investigated [9].
  • Haplotype segregation correlated with specific CIR in vivo and in vitro using lepromin [10].
  • Criterion measures were maximal isometric force of the elbow flexors (MIF), range of motion (ROM) about the elbow, mid and distal arm circumference (CIR; to assess swelling), soreness with movement and palpation (SOR), and blood levels of creatine kinase (CK) and lactate dehydrogenase (LDH) [11].

Anatomical context of CIR

  • Then the effect of CIR on splicing was investigated using the E1a minigene as a reporter in HeLa cells [9].
  • Results of 13 previously derived prediction equations using various combinations of height, BW, age, BIA, SF, or CIR measurements as independent variables to predict fat-free mass (FFM), fat mass (FM), and percent body fat (%Fat) were compared with HW [12].
  • Neurons in the VLM have been shown to be involved in the maintenance of vasomotor tone, in baroreceptor and chemoreceptor (central and peripheral) reflex mechanisms, in mediating the CIR and somatosympathetic reflexes and in the control of the secretion of vasopressin [13].
  • The results show that the compound impulse response, CIR, for the brain stem consists of five recognizable peaks [14].
  • The purpose of this study was to document temporal and spatial gait parameters of adult patients with the use of the GAITRite system (CIR Systems Inc, Clifton, NJ) after the patients were burned on their lower extremities and to compare these results with previous data reported for normal subjects [15].

Associations of CIR with chemical compounds

  • In addition to a basic lysine and acidic serine-rich (BA) domain and a zinc knuckle-like motif, CIR has an arginine/serine dipeptide repeat (RS) domain in its C terminal region [9].
  • Glutathione S-transferase affinity assays confirmed interaction between LANA and SAP30 and also demonstrated interactions between LANA and two other members of the corepressor complex, mSin3A and CIR [16].
  • The CIR Sand Casting System replaces plaster of Paris with sand for forming both a negative sand mould and a positive sand model, which can be modified for either thermoplastic socket formation or resin lamination [17].

Other interactions of CIR

  • These results indicate that CIR is a member of the family of SR-related proteins and that CIR plays a role in splicing regulation [9].

Analytical, diagnostic and therapeutic context of CIR

  • The combination of GLUT (sum of glucose values 0 to 3 hours of the OGTT) and CIR achieved significant separation (P less than .0004) [18].
  • There was a significant increase in CIR of the mid and distal biceps, SOR with movement and palpation, CK, and LDH (time effect, p < 0.05), indicating that there was significant muscle damage [11].


  1. Eosinophilic enterocolitis diagnosed by means of technetium-99m albumin scintigraphy and treated with budesonide (CIR). Russel, M.G., Zeijen, R.N., Brummer, R.J., de Bruine, A.P., van Kroonenburgh, M.J., Stockbrügger, R.W. Gut (1994) [Pubmed]
  2. Reactive hypoglycemia in lean young women with PCOS and correlations with insulin sensitivity and with beta cell function. Altuntas, Y., Bilir, M., Ucak, S., Gundogdu, S. Eur. J. Obstet. Gynecol. Reprod. Biol. (2005) [Pubmed]
  3. Chigger mite infestation of small mammals in a feral biotope of a public park area of south Delhi. Saxena, V.K. The Journal of communicable diseases. (1989) [Pubmed]
  4. In vitro antiproliferative effect of six Salvia species on human tumor cell lines. Fiore, G., Nencini, C., Cavallo, F., Capasso, A., Bader, A., Giorgi, G., Micheli, L. Phytotherapy research : PTR. (2006) [Pubmed]
  5. Relationship of personality disorders to observer ratings of interpersonal style in forensic psychiatric patients. Blackburn, R. J. Personal. Disord. (1998) [Pubmed]
  6. CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. Hsieh, J.J., Zhou, S., Chen, L., Young, D.B., Hayward, S.D. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  7. Reduced ability to clear ultrafilterable platinum with repeated courses of cisplatin. Reece, P.A., Stafford, I., Russell, J., Gill, P.G. J. Clin. Oncol. (1986) [Pubmed]
  8. Glucose tolerance and insulin release, a mathematical approach. II. Approximation of the peripheral insulin resistance after oral glucose loading. Sluiter, W.J., Erkelens, D.W., Terpstra, P., Reitsma, W.D., Doorenbos, H. Diabetes (1976) [Pubmed]
  9. CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing. Maita, H., Kitaura, H., Ariga, H., Iguchi-Ariga, S.M. Exp. Cell Res. (2005) [Pubmed]
  10. Molecular mechanisms of MHC linked susceptibility in leprosy: towards the development of synthetic vaccines. Gorodezky, C., Alaez, C., Munguía, A., Cruz, R., Vazquez, A., Camacho, A., Flores, O., Rodriguez, M., Rodriguez, O. Tuberculosis (Edinburgh, Scotland) (2004) [Pubmed]
  11. The effects of creatine supplementation on exercise-induced muscle damage. Rawson, E.S., Gunn, B., Clarkson, P.M. Journal of strength and conditioning research / National Strength & Conditioning Association. (2001) [Pubmed]
  12. Use of bioelectrical impedance to assess body composition changes at high altitude. Fulco, C.S., Hoyt, R.W., Baker-Fulco, C.J., Gonzalez, J., Cymerman, A. J. Appl. Physiol. (1992) [Pubmed]
  13. Function of the ventrolateral medulla in the control of the circulation. Ciriello, J., Caverson, M.M., Polosa, C. Brain Res. (1986) [Pubmed]
  14. Compound impulse response for the brain stem derived through combinations of cochlear and brain stem recordings. Elberling, C. Scandinavian audiology. (1978) [Pubmed]
  15. Gait variables of patients after lower extremity burn injuries. Silverberg, R., Lombardo, G., Gorga, D., Nagler, W., Himel, H., Yurt, R. The Journal of burn care & rehabilitation. (2000) [Pubmed]
  16. Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells. Krithivas, A., Young, D.B., Liao, G., Greene, D., Hayward, S.D. J. Virol. (2000) [Pubmed]
  17. CIR sand casting system for trans-tibial socket. Wu, Y., Casanova, H., Smith, W.K., Edwards, M., Childress, D.S. Prosthetics and orthotics international. (2003) [Pubmed]
  18. Glucose intolerance in first-degree relatives of patients with Friedreich's ataxia is associated with insulin resistance: evidence for a closely linked inherited trait. Fantus, I.G., Janjua, N., Senni, H., Andermann, E. Metab. Clin. Exp. (1991) [Pubmed]
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