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MeSH Review

Specific Pathogen-Free Organisms

 
 
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Disease relevance of Specific Pathogen-Free Organisms

 

High impact information on Specific Pathogen-Free Organisms

  • Despite their immunological defects, IL-15(-/-) mice remained healthy when maintained under specific pathogen-free conditions [6].
  • We have characterized the progressive stages of chronic intestinal inflammation that develops spontaneously in specific pathogen-free (SPF) mice with a targeted disruption in the IL-10 gene (IL-10-/-) [7].
  • IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions [8].
  • Mice deficient in CD33 were viable and fertile in a controlled-access specific-pathogen-free vivarium, showed no major morphological or histological abnormalities, had no changes in bone marrow or peripheral leukocyte subpopulations, and had very minor differences in biochemical and erythrocyte parameters [9].
  • Production of both O2- and TNF-alpha by resident peritoneal macrophages from specific pathogen-free aged rats in response to priming and triggering stimuli was partially or fully restored by implantation of syngeneic pituitary grafts from young rats [10].
 

Chemical compound and disease context of Specific Pathogen-Free Organisms

 

Biological context of Specific Pathogen-Free Organisms

 

Anatomical context of Specific Pathogen-Free Organisms

 

Associations of Specific Pathogen-Free Organisms with chemical compounds

  • The rats were divided into three groups: ten high dose (3 mg retinol/day i.p.); five low dose (30 micrograms retinol/day i.p.); and ten controls (corn oil i.p.). All animals were housed in specific-pathogen-free conditions and permitted access to sterile laboratory chow (5.4 micrograms retinol/g chow) and water ad libitum [26].
  • Two groups of four specific-pathogen-free cats were exposed to PLV via the mucosal (oro-nasal) or parenteral (i.v.) route [27].
  • However, the femoral CFU-GM concentration in germfree mice and splenic CFU-GM concentration in experimentally contaminated specific-pathogen-free and germfree mice was not affected by polymyxin treatment [13].
  • Administration of polymyxin to experimentally contaminated specific-pathogen-free mice significantly diminished the hydroxyurea kill of femoral CFU-GM from 29 to 13% (P less than 0.02) and of splenic CFU-GM from 53 to 27% (P less than 0.005) [13].
  • Mg-dependent and (Na+ + K+)-stimulated adenosine triphosphatase (ATP-ase) activities were assayed in butanol extracts of duodenal tissue from germ-free, specific-pathogen-free, and ex-germfree mice associated with an indigenous microflora from specific-pathogen-free mice [28].
 

Gene context of Specific Pathogen-Free Organisms

 

Analytical, diagnostic and therapeutic context of Specific Pathogen-Free Organisms

References

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