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MeSH Review

Specific Pathogen-Free Organisms

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Disease relevance of Specific Pathogen-Free Organisms


High impact information on Specific Pathogen-Free Organisms

  • Despite their immunological defects, IL-15(-/-) mice remained healthy when maintained under specific pathogen-free conditions [6].
  • We have characterized the progressive stages of chronic intestinal inflammation that develops spontaneously in specific pathogen-free (SPF) mice with a targeted disruption in the IL-10 gene (IL-10-/-) [7].
  • IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions [8].
  • Mice deficient in CD33 were viable and fertile in a controlled-access specific-pathogen-free vivarium, showed no major morphological or histological abnormalities, had no changes in bone marrow or peripheral leukocyte subpopulations, and had very minor differences in biochemical and erythrocyte parameters [9].
  • Production of both O2- and TNF-alpha by resident peritoneal macrophages from specific pathogen-free aged rats in response to priming and triggering stimuli was partially or fully restored by implantation of syngeneic pituitary grafts from young rats [10].

Chemical compound and disease context of Specific Pathogen-Free Organisms


Biological context of Specific Pathogen-Free Organisms


Anatomical context of Specific Pathogen-Free Organisms


Associations of Specific Pathogen-Free Organisms with chemical compounds

  • The rats were divided into three groups: ten high dose (3 mg retinol/day i.p.); five low dose (30 micrograms retinol/day i.p.); and ten controls (corn oil i.p.). All animals were housed in specific-pathogen-free conditions and permitted access to sterile laboratory chow (5.4 micrograms retinol/g chow) and water ad libitum [26].
  • Two groups of four specific-pathogen-free cats were exposed to PLV via the mucosal (oro-nasal) or parenteral (i.v.) route [27].
  • However, the femoral CFU-GM concentration in germfree mice and splenic CFU-GM concentration in experimentally contaminated specific-pathogen-free and germfree mice was not affected by polymyxin treatment [13].
  • Administration of polymyxin to experimentally contaminated specific-pathogen-free mice significantly diminished the hydroxyurea kill of femoral CFU-GM from 29 to 13% (P less than 0.02) and of splenic CFU-GM from 53 to 27% (P less than 0.005) [13].
  • Mg-dependent and (Na+ + K+)-stimulated adenosine triphosphatase (ATP-ase) activities were assayed in butanol extracts of duodenal tissue from germ-free, specific-pathogen-free, and ex-germfree mice associated with an indigenous microflora from specific-pathogen-free mice [28].

Gene context of Specific Pathogen-Free Organisms


Analytical, diagnostic and therapeutic context of Specific Pathogen-Free Organisms


  1. Origin and kinetics of pulmonary macrophages during an inflammatory reaction induced by intravenous administration of heat-killed bacillus Calmette-Guérin. Blussé van Oud Alblas, A., van der Linden-Schrever, B., van Furth, R. J. Exp. Med. (1981) [Pubmed]
  2. Bacteroides vulgatus protects against Escherichia coli-induced colitis in gnotobiotic interleukin-2-deficient mice. Waidmann, M., Bechtold, O., Frick, J.S., Lehr, H.A., Schubert, S., Dobrindt, U., Loeffler, J., Bohn, E., Autenrieth, I.B. Gastroenterology (2003) [Pubmed]
  3. Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice. Engle, S.J., Ormsby, I., Pawlowski, S., Boivin, G.P., Croft, J., Balish, E., Doetschman, T. Cancer Res. (2002) [Pubmed]
  4. Increased susceptibility to feline leukemia virus infection in cats exposed to methylnitrosourea. Schaller, J.P., Mathes, L.E., Hoover, E.A., Koestner, A., Olsen, R.G. Cancer Res. (1978) [Pubmed]
  5. Establishment of murine endothelial cell lines that develop angiosarcomas in vivo: brief demonstration of a proposed animal model for Kaposi's sarcoma. Sato, N., Sato, T., Takahashi, S., Kikuchi, K. Cancer Res. (1986) [Pubmed]
  6. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. Kennedy, M.K., Glaccum, M., Brown, S.N., Butz, E.A., Viney, J.L., Embers, M., Matsuki, N., Charrier, K., Sedger, L., Willis, C.R., Brasel, K., Morrissey, P.J., Stocking, K., Schuh, J.C., Joyce, S., Peschon, J.J. J. Exp. Med. (2000) [Pubmed]
  7. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. Berg, D.J., Davidson, N., Kühn, R., Müller, W., Menon, S., Holland, G., Thompson-Snipes, L., Leach, M.W., Rennick, D. J. Clin. Invest. (1996) [Pubmed]
  8. IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions. Konishi, H., Tsutsui, H., Murakami, T., Yumikura-Futatsugi, S., Yamanaka, K., Tanaka, M., Iwakura, Y., Suzuki, N., Takeda, K., Akira, S., Nakanishi, K., Mizutani, H. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  9. CD33/Siglec-3 binding specificity, expression pattern, and consequences of gene deletion in mice. Brinkman-Van der Linden, E.C., Angata, T., Reynolds, S.A., Powell, L.D., Hedrick, S.M., Varki, A. Mol. Cell. Biol. (2003) [Pubmed]
  10. Interferon-gamma-induced priming for secretion of superoxide anion and tumor necrosis factor-alpha declines in macrophages from aged rats. Davila, D.R., Edwards, C.K., Arkins, S., Simon, J., Kelley, K.W. FASEB J. (1990) [Pubmed]
  11. Influence of adrenal corticosteroids on the susceptibility of cats to feline leukemia virus infection. Rojko, J.L., Hoover, E.A., Mathes, L.E., Krakowka, S., Olsen, R.G. Cancer Res. (1979) [Pubmed]
  12. Effect of interleukin-10 on gut-derived sepsis caused by Pseudomonas aeruginosa in mice. Matsumoto, T., Tateda, K., Miyazaki, S., Furuya, N., Ohno, A., Ishii, Y., Hirakata, Y., Yamaguchi, K. Antimicrob. Agents Chemother. (1998) [Pubmed]
  13. Myelopoiesis in experimentally contaminated specific-pathogen-free and germfree mice during oral administration of polymyxin. Goris, H., de Boer, F., van der Waaij, D. Infect. Immun. (1985) [Pubmed]
  14. Prevention of indigenous infection of mice with Escherichia coli by nonspecific immunostimulation. Nomoto, K., Yokokura, T., Mitsuyama, M., Yoshikai, Y., Nomoto, K. Antimicrob. Agents Chemother. (1992) [Pubmed]
  15. Inoculation of barrier-born pigs with Helicobacter pylori: a useful animal model for gastritis type B. Engstrand, L., Gustavsson, S., Jörgensen, A., Schwan, A., Scheynius, A. Infect. Immun. (1990) [Pubmed]
  16. Aging and glucose homeostasis in C57BL/6J male mice. Leiter, E.H., Premdas, F., Harrison, D.E., Lipson, L.G. FASEB J. (1988) [Pubmed]
  17. Study of full-length porcine endogenous retrovirus genomes with envelope gene polymorphism in a specific-pathogen-free Large White swine herd. Bösch, S., Arnauld, C., Jestin, A. J. Virol. (2000) [Pubmed]
  18. Pathogenicity of a thymidine kinase-deficient mutant of equine herpesvirus 1 in mice and specific pathogen-free foals. Slater, J.D., Gibson, J.S., Field, H.J. J. Gen. Virol. (1993) [Pubmed]
  19. Ectopic expression of B7-1 (CD80) on T lymphocytes in autoimmune lpr and gld mice. Weintraub, J.P., Cohen, P.L. Clin. Immunol. (1999) [Pubmed]
  20. Feline panleukopenia. II. The relationship of intestinal mucosal cell proliferation rates to viral infection and development of lesions. Carlson, J.H., Scott, F.W. Vet. Pathol. (1977) [Pubmed]
  21. Altered cholesteryl ester cycle is associated with lipid accumulation in herpesvirus-infected arterial smooth muscle cells. Hajjar, D.P., Falcone, D.J., Fabricant, C.G., Fabricant, J. J. Biol. Chem. (1985) [Pubmed]
  22. The role of iodine in autoimmune thyroiditis. Rose, N.R., Saboori, A.M., Rasooly, L., Burek, C.L. Crit. Rev. Immunol. (1997) [Pubmed]
  23. Role of environment in the development of "natural" hemagglutinins in Minnesota miniature swine. Scheffel, J.W., Kim, Y.B. Infect. Immun. (1979) [Pubmed]
  24. Mucus colonization as a determinant of pathogenicity in intestinal infection by Campylobacter jejuni: a mouse cecal model. Lee, A., O'Rourke, J.L., Barrington, P.J., Trust, T.J. Infect. Immun. (1986) [Pubmed]
  25. Calcitonin gene-related peptide in secretory granules of serous cells in the rat tracheal epithelium. Baluk, P., Nadel, J.A., McDonald, D.M. Am. J. Respir. Cell Mol. Biol. (1993) [Pubmed]
  26. Antiproliferative effect of vitamin A on xenotransplanted CaMa-15 cells. Wetherall, N.T., Mitchell, W.M., Halter, S.A. Cancer Res. (1984) [Pubmed]
  27. Puma lentivirus is controlled in domestic cats after mucosal exposure in the absence of conventional indicators of immunity. Terwee, J.A., Yactor, J.K., Sondgeroth, K.S., Vandewoude, S. J. Virol. (2005) [Pubmed]
  28. Influence of the indigenous gastrointestinal microbial flora on duodenal Mg2+ -dependent and (Na+ + K+) -stimulated adenosine triphosphatase activities in mice. Yolton, D.P., Savage, D.C. Infect. Immun. (1976) [Pubmed]
  29. Helicobacter hepaticus-induced colitis in interleukin-10-deficient mice: cytokine requirements for the induction and maintenance of intestinal inflammation. Kullberg, M.C., Rothfuchs, A.G., Jankovic, D., Caspar, P., Wynn, T.A., Gorelick, P.L., Cheever, A.W., Sher, A. Infect. Immun. (2001) [Pubmed]
  30. Dietary nucleic acids promote a shift in Th1/Th2 balance toward Th1-dominant immunity. Sudo, N., Aiba, Y., Takaki, A., Tanaka, K., Yu, X.N., Oyama, N., Koga, Y., Kubo, C. Clin. Exp. Allergy (2000) [Pubmed]
  31. Arginine metabolism during macrophage autocrine activation and infection with mouse hepatitis virus 3. Moreira, C., Tsuhako, M.H., de Franco, M.T., Modolell, M., Pereira, C.A. Immunobiology (2004) [Pubmed]
  32. Dysregulated luminal bacterial antigen-specific T-cell responses and antigen-presenting cell function in HLA-B27 transgenic rats with chronic colitis. Qian, B.F., Tonkonogy, S.L., Hoentjen, F., Dieleman, L.A., Sartor, R.B. Immunology (2005) [Pubmed]
  33. Neuropeptides concentrations in the skin of a murine (NC/Nga mice) model of atopic dermatitis. Katsuno, M., Aihara, M., Kojima, M., Osuna, H., Hosoi, J., Nakamura, M., Toyoda, M., Matsuda, H., Ikezawa, Z. J. Dermatol. Sci. (2003) [Pubmed]
  34. Single nucleotide polymorphisms of the prion protein gene (PRNP) in Chinese pig breeds. Meng, L., Zhao, D., Liu, H., Yang, J., Ning, Z. Xenotransplantation (2005) [Pubmed]
  35. Changes in pulmonary calcitonin gene-related peptide and protein gene product 9.5 innervation in rats infected with Mycoplasma pulmonis. Nohr, D., Buob, A., Gärtner, K., Weihe, E. Cell Tissue Res. (1996) [Pubmed]
  36. Effect of cytoxan-induced heteropenia on the response of specific-pathogen-free chickens to infectious bronchitis. Fulton, R.M., Thacker, H.L., Reed, W.M., DeNicola, D.B. Avian Dis. (1997) [Pubmed]
  37. Characterization of Toxoplasma gondii SAG2 expressed in insect cells by recombinant baculovirus and evaluation of its diagnostic potential in an enzyme-linked immunosorbent assay. Huang, X., Xuan, X., Suzuki, H., Sugimoto, C., Nagasawa, H., Fujisaki, K., Mikami, T., Igarashi, I. Clin. Diagn. Lab. Immunol. (2002) [Pubmed]
  38. Mycoplasma gateae arthritis and tenosynovitis in cats: case report and experimental reproduction of the disease. Moise, N.S., Crissman, J.W., Fairbrother, J.F., Baldwin, C. Am. J. Vet. Res. (1983) [Pubmed]
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