The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CABYR  -  calcium binding tyrosine-(Y)...

Homo sapiens

Synonyms: CABYRa, CABYRc, CABYRc/d, CABYRe, CBP86, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CABYR


High impact information on CABYR

  • It is presently unknown if proteins encoded by the predicted coding region B of CABYR are translated during spermiogenesis, where they localize, or which CABYR isoforms bind calcium [2].
  • CABYR is a highly polymorphic, sperm flagellar calcium-binding protein that is tyrosine as well as serine/threonine phosphorylated during capacitation [2].
  • CABYR localizes to the principal piece of the human sperm flagellum in association with the fibrous sheath and is the first demonstration of a sperm protein that gains calcium-binding capacity when phosphorylated during capacitation [3].
  • Six variants of CABYR containing two coding regions (CR-A and CR-B) were cloned from human testis cDNA libraries, including five variants with alternative splice deletions [3].
  • A motif homologous to the RII dimerization domain of PK-A was present in the N-terminus of CR-A in four CABYR variants [3].

Biological context of CABYR

  • These observations confirmed that, despite the presence of the stop codon in CR-A, splice variants containing CR-B are expressed during spermiogenesis and assemble into the fibrous sheath of the principal piece; however, calcium binding occurs only to those CABYR isoforms containing CABYR-A [2].
  • In kinase assay, we also showed that CABYR variants act as an ideal substrate for GSK3beta within the extensin-like domain and phosphorylation sites on CABYR were mapped [1].
  • The fSP13 bears the closest amino acid similarity to two human sperm proteins: fibrousheathin 2 and testis-specific calcium binding protein 86-VII [4].
  • Here we present linkage data from a large German family displaying AD-FSP with anticipation which confirms the existence of the FSP2 locus on chromosome 2p [5].

Associations of CABYR with chemical compounds


Physical interactions of CABYR

  • Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain [1].

Other interactions of CABYR

  • Molecular characterization showed that CABYR variants formed a dimer with a proline-rich extensin-like domain, which slightly overlapped with GSK3beta-binding site [1].

Analytical, diagnostic and therapeutic context of CABYR

  • Interestingly, Northern blot showed that CABYR transcripts were expressed more distinctly in the fetal brain than in the adult brain, suggesting that this protein may play a role during brain development [1].


  1. Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain. Hsu, H.C., Lee, Y.L., Cheng, T.S., Howng, S.L., Chang, L.K., Lu, P.J., Hong, Y.R. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  2. Translation and assembly of CABYR coding region B in fibrous sheath and restriction of calcium binding to coding region A. Kim, Y.H., Jha, K.N., Mandal, A., Vanage, G., Farris, E., Snow, P.L., Klotz, K., Naaby-Hansen, S., Flickinger, C.J., Herr, J.C. Dev. Biol. (2005) [Pubmed]
  3. CABYR, a novel calcium-binding tyrosine phosphorylation-regulated fibrous sheath protein involved in capacitation. Naaby-Hansen, S., Mandal, A., Wolkowicz, M.J., Sen, B., Westbrook, V.A., Shetty, J., Coonrod, S.A., Klotz, K.L., Kim, Y.H., Bush, L.A., Flickinger, C.J., Herr, J.C. Dev. Biol. (2002) [Pubmed]
  4. Identification of a new, testis-specific sperm antigen localized on the principal piece of the spermatozoa tail in the fox (Vulpes vulpes). Verdier, Y., Farré, G., Rouet, N., Kele, Z., Janáky, T., Boué, F. Biol. Reprod. (2005) [Pubmed]
  5. Autosomal dominant spastic paraplegia with anticipation maps to a 4-cM interval on chromosome 2p21-p24 in a large German family. Bürger, J., Metzke, H., Paternotte, C., Schilling, F., Hazan, J., Reis, A. Hum. Genet. (1996) [Pubmed]
WikiGenes - Universities