The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Prrx1  -  paired related homeobox 1

Rattus norvegicus

Synonyms: PRX-1, Paired mesoderm homeobox protein 1, Paired-related homeobox protein 1, Pmx1, Prx-1, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Prrx1

 

High impact information on Prrx1

 

Biological context of Prrx1

  • This gene, termed rHox, was isolated from a cDNA library derived from rat osteoblast-like cells [4].
  • Transfection experiments using an rHox expression vector showed a strong repression of target promoter activity, regardless of whether the target promoters contained homeodomain binding response elements [4].
  • These data suggest that rHox is a potent negative regulator of gene expression, although the specific role of rHox in bone gene regulation remains to be determined [4].
 

Anatomical context of Prrx1

  • In conclusion, current evidence suggests that rHox acts as a negative regulator of osteoblast differentiation [1].
 

Other interactions of Prrx1

 

Analytical, diagnostic and therapeutic context of Prrx1

References

  1. Expression of rat homeobox gene, rHOX, in developing and adult tissues in mice and regulation of its mRNA expression in osteoblasts by bone morphogenetic protein 2 and parathyroid hormone-related protein. Hu, Y.S., Zhou, H., Kartsogiannis, V., Eisman, J.A., Martin, T.J., Ng, K.W. Mol. Endocrinol. (1998) [Pubmed]
  2. Vitamin E differentially regulates the expression of peroxiredoxin-1 and -6 in alveolar type II cells. Tölle, A., Schlame, M., Charlier, N., Guthmann, F., Rüstow, B. Free Radic. Biol. Med. (2005) [Pubmed]
  3. Regulation of vascular smooth muscle cell growth and adhesion by paired-related homeobox genes. Jones, F.S., McKean, D.M., Meech, R., Edelman, D.B., Oakey, R.J., Jones, P.L. Chest (2002) [Pubmed]
  4. rHox: a homeobox gene expressed in osteoblastic cells. Hu, Y., Flanagan, J., Brennan, D.P., Zhou, H., Ng, K.W., Eisman, J.A., Morrison, N.A. J. Cell. Biochem. (1995) [Pubmed]
 
WikiGenes - Universities