High impact information on Eif2s3y

• However, the introduction of Eif2s3y restores normal spermatogonial proliferation and progression through meiotic prophase [1].
• A deletion variant of Sxra, termed Sxrb, which lacks Hya, SDMA expression, Spy and some Zfy-2 sequences, makes positional cloning of these genes possible [2].
• The critical role of this enzyme in nuclear DNA replication together with the testis-specific expression of Sby suggests Sby as a candidate for the spermatogenic gene Spy [2].
• Therefore A1s9Y-1 is a candidate for the spermatogenesis gene, Spy, which maps to this region [3].
• The Delta Sxrb deletion interval of the mouse Y chromosome contains Spy, a spermatogenesis factor gene(s) whose expression is essential for the postnatal development of the mitotic germ cells, spermatogonia [4].

Biological context of Eif2s3y

• Two genes (Dby and Eif2s3y) were mapped to the Y chromosome and were expressed in male blastocysts [5].
• However, we have recently shown that only two Y genes, the testis determinant Sry and the translation initiation factor Eif2s3y, are essential for spermatogenesis to proceed to the round spermatid stage [6].
• The effect of a sex difference in Eif2s3x transcription, however, could potentially be offset by the additional expression in male brains of its Y-linked homologue Eif2s3y which was found in similar brain regions [7].
• The first direct effect of the Y in the germ line occurs at the initiation of the spermatogenic cycles (approx. 1 week after birth) when a Y-chromosomal gene (Spy) is needed for normal spermatogonial survival and progression to meiosis [8].
• It is of interest that in mouse a Y-linked gene controlling spermatogenesis (Spy) maps near Hya on the Sxr fragment: they could be the same or closely linked genes [9].

Enzymatic interactions of Eif2s3y

• Hya and Spy map to DNA deleted from the Sxr region in the deletion variant Sxrb (the delta Sxrb DNA) [10].

Other interactions of Eif2s3y

• With the object of cloning Hya and Spy, we initiated chromosome walking in the delta Sxrb DNA [10].

References