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Gene Review

Eif2s3y  -  eukaryotic translation initiation factor 2...

Mus musculus

Synonyms: Eif-2gy, Eukaryotic translation initiation factor 2 subunit 3, Y-linked, Eukaryotic translation initiation factor 2 subunit gamma, Y-linked, Spy, Tfy, ...
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High impact information on Eif2s3y

  • However, the introduction of Eif2s3y restores normal spermatogonial proliferation and progression through meiotic prophase [1].
  • A deletion variant of Sxra, termed Sxrb, which lacks Hya, SDMA expression, Spy and some Zfy-2 sequences, makes positional cloning of these genes possible [2].
  • The critical role of this enzyme in nuclear DNA replication together with the testis-specific expression of Sby suggests Sby as a candidate for the spermatogenic gene Spy [2].
  • Therefore A1s9Y-1 is a candidate for the spermatogenesis gene, Spy, which maps to this region [3].
  • The Delta Sxrb deletion interval of the mouse Y chromosome contains Spy, a spermatogenesis factor gene(s) whose expression is essential for the postnatal development of the mitotic germ cells, spermatogonia [4].

Biological context of Eif2s3y

  • Two genes (Dby and Eif2s3y) were mapped to the Y chromosome and were expressed in male blastocysts [5].
  • However, we have recently shown that only two Y genes, the testis determinant Sry and the translation initiation factor Eif2s3y, are essential for spermatogenesis to proceed to the round spermatid stage [6].
  • The effect of a sex difference in Eif2s3x transcription, however, could potentially be offset by the additional expression in male brains of its Y-linked homologue Eif2s3y which was found in similar brain regions [7].
  • The first direct effect of the Y in the germ line occurs at the initiation of the spermatogenic cycles (approx. 1 week after birth) when a Y-chromosomal gene (Spy) is needed for normal spermatogonial survival and progression to meiosis [8].
  • It is of interest that in mouse a Y-linked gene controlling spermatogenesis (Spy) maps near Hya on the Sxr fragment: they could be the same or closely linked genes [9].

Enzymatic interactions of Eif2s3y

  • Hya and Spy map to DNA deleted from the Sxr region in the deletion variant Sxrb (the delta Sxrb DNA) [10].

Other interactions of Eif2s3y


  1. A Y-encoded subunit of the translation initiation factor Eif2 is essential for mouse spermatogenesis. Mazeyrat, S., Saut, N., Grigoriev, V., Mahadevaiah, S.K., Ojarikre, O.A., Rattigan A, n.u.l.l., Bishop, C., Eicher, E.M., Mitchell, M.J., Burgoyne, P.S. Nat. Genet. (2001) [Pubmed]
  2. Homology of a candidate spermatogenic gene from the mouse Y chromosome to the ubiquitin-activating enzyme E1. Mitchell, M.J., Woods, D.R., Tucker, P.K., Opp, J.S., Bishop, C.E. Nature (1991) [Pubmed]
  3. A candidate spermatogenesis gene on the mouse Y chromosome is homologous to ubiquitin-activating enzyme E1. Kay, G.F., Ashworth, A., Penny, G.D., Dunlop, M., Swift, S., Brockdorff, N., Rastan, S. Nature (1991) [Pubmed]
  4. The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region. Mazeyrat, S., Saut, N., Sargent, C.A., Grimmond, S., Longepied, G., Ehrmann, I.E., Ellis, P.S., Greenfield, A., Affara, N.A., Mitchell, M.J. Hum. Mol. Genet. (1998) [Pubmed]
  5. Comparison of gene expression in male and female mouse blastocysts revealed imprinting of the X-linked gene, Rhox5/Pem, at preimplantation stages. Kobayashi, S., Isotani, A., Mise, N., Yamamoto, M., Fujihara, Y., Kaseda, K., Nakanishi, T., Ikawa, M., Hamada, H., Abe, K., Okabe, M. Curr. Biol. (2006) [Pubmed]
  6. A new deletion of the mouse Y chromosome long arm associated with the loss of Ssty expression, abnormal sperm development and sterility. Touré, A., Szot, M., Mahadevaiah, S.K., Rattigan, A., Ojarikre, O.A., Burgoyne, P.S. Genetics (2004) [Pubmed]
  7. Sexually dimorphic expression of the X-linked gene Eif2s3x mRNA but not protein in mouse brain. Xu, J., Watkins, R., Arnold, A.P. Gene Expr. Patterns (2006) [Pubmed]
  8. The role of the mammalian Y chromosome in spermatogenesis. Burgoyne, P.S. Development (1987) [Pubmed]
  9. Mapping the H-Y gene. Simpson, E., Chandler, P., McLaren, A., Goulmy, E., Disteche, C.M., Page, D.C., Ferguson-Smith, M.A. Development (1987) [Pubmed]
  10. A structural analysis of the Sxr region of the mouse Y chromosome. Mitchell, M.J., Bishop, C.E. Genomics (1992) [Pubmed]
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