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Gene Review

HBB  -  hemoglobin, beta

Bos taurus

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High impact information on HBB

  • Cells were transfected with reporter gene constructs containing deletion mutations of the 5'-flanking region of the bovine CYP11A gene linked to the minimal beta-globin gene [1].
  • We have examined the transcriptional activity of four cis-elements, Ad1(CRE), Ad2, Ad3, and Ad4, that are present in the promoter of the bovine CYP11B (11 beta-hydroxylase P-450) gene using beta-globin reporter gene constructs and transient transfection into steroidogenic and nonsteroidogenic cell types [2].
  • Southern blot analysis indicated that both lagans appeared twice within the cow haploid genome, with the second copies lying outside the cow beta-globin locus [3].
  • The 12-member beta-globin gene locus of the goat contains three beta(adult)-type pseudogenes, one in each of three four-gene subsets of the locus [4].
  • In this developing cohort, a tightly programmed sequence of gene expression was observed, and maximal expression of c-kit, EPO receptor, and beta-globin transcripts occurred at 72, 96, and 120 hours post-TAP withdrawal, respectively [5].

Biological context of HBB


Anatomical context of HBB

  • Isolated beta-globin chains reproduce, in normal red cell membranes, the defective binding of spectrin to alpha-thalassaemic membranes [8].
  • Spectrin-depleted inside-out membrane vesicles (IOVs) derived from membranes incubated with beta-globin chains bound only 9 +/- 3% as much spectrin as IOVs from control membranes incubated with bovine serum albumin [8].
  • Collagen alpha 1 type XII, collagen alpha 2 type I, collagen alpha 2 type V, epsilon 4 beta-globin, osteonectin, and uroplakin were expressed at significantly greater levels in ovine Day 17 allantois compared to Day 13 conceptuses [9].
  • The amount of beta-globin which was synthesized by calf liver cells varied from 0.3 to 3.5% of the non-alpha globin chains and remained at a low level for all the fetuses which were studied [10].
  • Fingerprint analysis of peptides obtained by trypsinolysis of radioactive beta-globin chains revealed that its structure was closely related to that of beta-globin, isolated from cow bone marrow cells [10].

Associations of HBB with chemical compounds


Other interactions of HBB

  • These studies show that isolated beta-globin chains (but not alpha-globin chains) can produce a spectrin-binding defect in normal red cell membranes similar to that seen in alpha thalassaemia [8].
  • Significant deviations from Hardy-Weinberg equilibrium occurred in some populations at the HBB and TF loci [12].


  1. Regulation of expression of the CYP11A (P450scc) gene in bovine ovarian luteal cells by forskolin and phorbol esters. Begeot, M., Shetty, U., Kilgore, M., Waterman, M., Simpson, E. J. Biol. Chem. (1993) [Pubmed]
  2. Activation of CYP11A and CYP11B gene promoters by the steroidogenic cell-specific transcription factor, Ad4BP. Morohashi, K., Zanger, U.M., Honda, S., Hara, M., Waterman, M.R., Omura, T. Mol. Endocrinol. (1993) [Pubmed]
  3. A composite transposon 3' to the cow fetal globin gene binds a sequence specific factor. Zelnick, C.R., Burks, D.J., Duncan, C.H. Nucleic Acids Res. (1987) [Pubmed]
  4. Structure of the goat psi beta y beta-globin pseudogene. Analysis of goat pseudogene evolutionary patterns. Shapiro, S.G., Moshirfar, M. J. Mol. Biol. (1989) [Pubmed]
  5. An optimized system for studies of EPO-dependent murine pro-erythroblast development. Zhang, D., Johnson, M.M., Miller, C.P., Pircher, T.J., Geiger, J.N., Wojchowski, D.M. Exp. Hematol. (2001) [Pubmed]
  6. Physical mapping of ADCY2, FSHB and HBB to bovine chromosome 15 by FISH of bovine bacterial artificial chromosome clones. Amarante, M.R., Gallagher, D.S., Burzlaff, J.D., Lopes, C.R., Womack, J.E., Taylor, J.F., Davis, S.K. Cytogenet. Cell Genet. (1999) [Pubmed]
  7. Regulation of CYP11A gene expression in bovine ovarian granulosa cells in primary culture by cAMP and phorbol esters is conferred by a common cis-acting element. Lauber, M.E., Picton, H.M., Begeot, M., Momoi, K., Waterman, M.R., Simpson, E.R. Mol. Cell. Endocrinol. (1993) [Pubmed]
  8. Isolated beta-globin chains reproduce, in normal red cell membranes, the defective binding of spectrin to alpha-thalassaemic membranes. Shalev, O., Shinar, E., Lux, S.E. Br. J. Haematol. (1996) [Pubmed]
  9. Expression of genes associated with allantois emergence in ovine and bovine conceptuses. Ledgard, A.M., Lee, R.S., Peterson, A.J. Mol. Reprod. Dev. (2006) [Pubmed]
  10. The synthesis of adult hemoglobins during hepatic erythropoiesis in the calf fetus. Lavrijsen, K., Verwilghen, R.L. Hemoglobin (1983) [Pubmed]
  11. Importance of helices A and H in oxygen binding differences between bovine and human hemoglobins. Baudin-Creuza, V., Vasseur-Godbillon, C., Kister, J., Domingues, E., Poyart, C., Marden, M., Pagnier, J. Hemoglobin (2002) [Pubmed]
  12. Polymorphisms in blood proteins of Bos indicus and Bos taurus cattle breeds of Cameroon and Nigeria, and description of new albumin variants. Ibeagha-Awemu, E.M., Jäger, S., Erhardt, G. Biochem. Genet. (2004) [Pubmed]
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