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Serp1  -  stress-associated endoplasmic reticulum...

Mus musculus

Synonyms: D3Ucla1, Ramp4, Ribosome-attached membrane protein 4, Stress-associated endoplasmic reticulum protein 1
 
 
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Disease relevance of D3Ucla1

  • Significantly, Serp-1 blocked intimal hyperplasia (p < 0.0001) after aortic allograft transplant (p < 0.0001) in PAI-1-deficient mice [1].
  • Myxoma viral serpin, Serp-1, a unique interceptor of coagulation and innate immune pathways [2].
  • The effects of Serp-1 on activation of human platelets, endothelial cells, monocytes and T cells that mediate thrombosis and innate immune responses were therefore examined [2].
  • Effects of Serp-1 on de novo atherogenesis were characterized by a significantly lower plaque size than that of control mice (18+/-5x10(3) versus 57+/-12x10(3) microm2, respectively; P=0.007) [3].
  • Treatment of advanced lesions with Serp-1 resulted in a decrease in plaque size and lumen stenosis (P=0.028) [3].
 

High impact information on D3Ucla1

 

Biological context of D3Ucla1

 

Anatomical context of D3Ucla1

 

Analytical, diagnostic and therapeutic context of D3Ucla1

  • Serp-1 did not inhibit plaque growth in uPAR-deficient mice after aortic allograft transplant [1].

References

  1. Serp-1, a viral anti-inflammatory serpin, regulates cellular serine proteinase and serpin responses to vascular injury. Dai, E., Guan, H., Liu, L., Little, S., McFadden, G., Vaziri, S., Cao, H., Ivanova, I.A., Bocksch, L., Lucas, A. J. Biol. Chem. (2003) [Pubmed]
  2. Myxoma viral serpin, Serp-1, a unique interceptor of coagulation and innate immune pathways. Viswanathan, K., Liu, L., Vaziri, S., Dai, E., Richardson, J., Togonu-Bickersteth, B., Vatsya, P., Christov, A., Lucas, A.R. Thromb. Haemost. (2006) [Pubmed]
  3. Serine protease inhibitor Serp-1 strongly impairs atherosclerotic lesion formation and induces a stable plaque phenotype in ApoE-/-mice. Bot, I., von der Thüsen, J.H., Donners, M.M., Lucas, A., Fekkes, M.L., de Jager, S.C., Kuiper, J., Daemen, M.J., van Berkel, T.J., Heeneman, S., Biessen, E.A. Circ. Res. (2003) [Pubmed]
  4. Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Warden, C.H., Mehrabian, M., He, K.Y., Yoon, M.Y., Diep, A., Xia, Y.R., Wen, P.Z., Svenson, K.L., Sparkes, R.S., Lusis, A.J. Genomics (1993) [Pubmed]
 
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