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Gene Review

LECT1  -  leukocyte cell derived chemotaxin 1

Bos taurus

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High impact information on CHM-I


Biological context of CHM-I

  • Bovine chondromodulin-I cDNA revealed that the mature protein consists of 121 amino acids with three possible glycosylation sites and is coded as the C-terminal part of a larger precursor [2].
  • These results suggest that ChM-I participates in an autocrine signaling mechanism for the anchorage-independent growth of chondrocytes in vitro [3].

Anatomical context of CHM-I


Associations of CHM-I with chemical compounds

  • A glycosylated protein (small, cartilage-derived glycoprotein, SCGP) of approximately 18 kDa with unknown function has been isolated from dissociative extracts of bovine nasal cartilage and its primary structure determined [5].
  • Here we purified the inhibitory activity in the 10-50 kDa fraction of guanidine extracts from fetal bovine epiphyseal cartilage, and found that the inhibitor was identical with chondromodulin-I (ChM-I) [6].

Other interactions of CHM-I

  • ChM-I alone weakly stimulated the formation of chondrocyte colonies, but it markedly stimulated colony formation synergistically in the presence of an optimal dose of FGF-2 [3].

Analytical, diagnostic and therapeutic context of CHM-I

  • On northern blot analysis, expression of chondromodulin-I mRNA was observed only in cartilage [2].
  • In situ hybridization and immunohistochemical studies indicated that ChM-I is specifically expressed in the avascular zone of cartilage in developing bone, but not present in calcifying cartilage [1].


  1. Identification of chondromodulin I as a novel endothelial cell growth inhibitor. Purification and its localization in the avascular zone of epiphyseal cartilage. Hiraki, Y., Inoue, H., Iyama, K., Kamizono, A., Ochiai, M., Shukunami, C., Iijima, S., Suzuki, F., Kondo, J. J. Biol. Chem. (1997) [Pubmed]
  2. Molecular cloning of a new class of cartilage-specific matrix, chondromodulin-I, which stimulates growth of cultured chondrocytes. Hiraki, Y., Tanaka, H., Inoue, H., Kondo, J., Kamizono, A., Suzuki, F. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  3. Identification of an autocrine chondrocyte colony-stimulating factor: chondromodulin-I stimulates the colony formation of growth plate chondrocytes in agarose culture. Inoue, H., Kondo, J., Koike, T., Shukunami, C., Hiraki, Y. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  4. Stimulation of osteoblast proliferation by the cartilage-derived growth promoting factors chondromodulin-I and -II. Mori, Y., Hiraki, Y., Shukunami, C., Kakudo, S., Shiokawa, M., Kagoshima, M., Mano, H., Hakeda, Y., Kurokawa, T., Suzuki, F., Kumegawa, M. FEBS Lett. (1997) [Pubmed]
  5. An 18-kDa glycoprotein from bovine nasal cartilage. Isolation and primary structure of small, cartilage-derived glycoprotein. Neame, P.J., Treep, J.T., Young, C.N. J. Biol. Chem. (1990) [Pubmed]
  6. Inhibition of DNA synthesis and tube morphogenesis of cultured vascular endothelial cells by chondromodulin-I. Hiraki, Y., Kono, T., Sato, M., Shukunami, C., Kondo, J. FEBS Lett. (1997) [Pubmed]
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