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MeSH Review

Autocrine Communication

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Disease relevance of Autocrine Communication


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Chemical compound and disease context of Autocrine Communication


Biological context of Autocrine Communication


Anatomical context of Autocrine Communication


Associations of Autocrine Communication with chemical compounds


Gene context of Autocrine Communication


  1. Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor. Takayama, H., LaRochelle, W.J., Sharp, R., Otsuka, T., Kriebel, P., Anver, M., Aaronson, S.A., Merlino, G. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells. Zheng, R., Levis, M., Piloto, O., Brown, P., Baldwin, B.R., Gorin, N.C., Beran, M., Zhu, Z., Ludwig, D., Hicklin, D., Witte, L., Li, Y., Small, D. Blood (2004) [Pubmed]
  3. Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors. Lokker, N.A., Sullivan, C.M., Hollenbach, S.J., Israel, M.A., Giese, N.A. Cancer Res. (2002) [Pubmed]
  4. Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells. Bachelder, R.E., Crago, A., Chung, J., Wendt, M.A., Shaw, L.M., Robinson, G., Mercurio, A.M. Cancer Res. (2001) [Pubmed]
  5. JNK regulates expression and autocrine signaling of TGF-beta1. Pardoux, C., Derynck, R. Mol. Cell (2004) [Pubmed]
  6. CTLA-4-Ig activates forkhead transcription factors and protects dendritic cells from oxidative stress in nonobese diabetic mice. Fallarino, F., Bianchi, R., Orabona, C., Vacca, C., Belladonna, M.L., Fioretti, M.C., Serreze, D.V., Grohmann, U., Puccetti, P. J. Exp. Med. (2004) [Pubmed]
  7. Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor. Dong, J., Opresko, L.K., Dempsey, P.J., Lauffenburger, D.A., Coffey, R.J., Wiley, H.S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  8. Ligation of intestinal epithelial CD1d induces bioactive IL-10: critical role of the cytoplasmic tail in autocrine signaling. Colgan, S.P., Hershberg, R.M., Furuta, G.T., Blumberg, R.S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  9. Real-time quantitative measurement of autocrine ligand binding indicates that autocrine loops are spatially localized. Lauffenburger, D.A., Oehrtman, G.T., Walker, L., Wiley, H.S. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  10. Abrogation of transforming growth factor-alpha/epidermal growth factor receptor autocrine signaling by an RXR-selective retinoid (LGD1069, Targretin) in head and neck cancer cell lines. Song, J.I., Lango, M.N., Hwang, J.D., Drenning, S.D., Zeng, Q., Lamph, W.W., Grandis, J.R. Cancer Res. (2001) [Pubmed]
  11. Imaging epidermal growth factor receptor phosphorylation in human colorectal cancer cells and human tissues. Keese, M., Magdeburg, R.J., Herzog, T., Hasenberg, T., Offterdinger, M., Pepperkok, R., Sturm, J.W., Bastiaens, P.I. J. Biol. Chem. (2005) [Pubmed]
  12. TLR3 can directly trigger apoptosis in human cancer cells. Salaun, B., Coste, I., Rissoan, M.C., Lebecque, S.J., Renno, T. J. Immunol. (2006) [Pubmed]
  13. Nodal stability determines signaling range. Le Good, J.A., Joubin, K., Giraldez, A.J., Ben-Haim, N., Beck, S., Chen, Y., Schier, A.F., Constam, D.B. Curr. Biol. (2005) [Pubmed]
  14. p38 MAPK and NF-kappa B collaborate to induce interleukin-6 gene expression and release. Evidence for a cytoprotective autocrine signaling pathway in a cardiac myocyte model system. Craig, R., Larkin, A., Mingo, A.M., Thuerauf, D.J., Andrews, C., McDonough, P.M., Glembotski, C.C. J. Biol. Chem. (2000) [Pubmed]
  15. Alpha-tocopheryl succinate inhibits malignant mesothelioma by disrupting the fibroblast growth factor autocrine loop: mechanism and the role of oxidative stress. Stapelberg, M., Gellert, N., Swettenham, E., Tomasetti, M., Witting, P.K., Procopio, A., Neuzil, J. J. Biol. Chem. (2005) [Pubmed]
  16. Neuregulin stimulates myogenic differentiation in an autocrine manner. Kim, D., Chi, S., Lee, K.H., Rhee, S., Kwon, Y.K., Chung, C.H., Kwon, H., Kang, M.S. J. Biol. Chem. (1999) [Pubmed]
  17. Multiple roles for heparin-binding epidermal growth factor-like growth factor are suggested by its cell-specific expression during the human endometrial cycle and early placentation. Leach, R.E., Khalifa, R., Ramirez, N.D., Das, S.K., Wang, J., Dey, S.K., Romero, R., Armant, D.R. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  18. Schwann cells express erythropoietin receptor and represent a major target for Epo in peripheral nerve injury. Li, X., Gonias, S.L., Campana, W.M. Glia (2005) [Pubmed]
  19. Downmodulation of TGF-alpha protein expression with antisense oligonucleotides inhibits proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells. Grandis, J.R., Chakraborty, A., Zeng, Q., Melhem, M.F., Tweardy, D.J. J. Cell. Biochem. (1998) [Pubmed]
  20. LPS stimulation of TNF-receptor deficient macrophages: a differential role for TNF-alpha autocrine signaling in the induction of cytokine and nitric oxide production. Clemons-Miller, A.R., Cox, G.W., Suttles, J., Stout, R.D. Immunobiology (2000) [Pubmed]
  21. Epidermal growth factor receptor autocrine signaling in RIE-1 cells transformed by the Ras oncogene enhances radiation resistance. Grana, T.M., Sartor, C.I., Cox, A.D. Cancer Res. (2003) [Pubmed]
  22. Induced autocrine signaling through the epidermal growth factor receptor contributes to the response of mammary epithelial cells to tumor necrosis factor alpha. Chen, W.N., Woodbury, R.L., Kathmann, L.E., Opresko, L.K., Zangar, R.C., Wiley, H.S., Thrall, B.D. J. Biol. Chem. (2004) [Pubmed]
  23. Cross-talk between the autocrine (mitogenic) pheromone loop of the ciliate Euplotes raikovi and the intracellular cyclic AMP concentration. Apone, F., Vallesi, A., Di Pretoro, B., Luporini, P. Exp. Cell Res. (2003) [Pubmed]
  24. Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin. Mercurio, A.M., Bachelder, R.E., Bates, R.C., Chung, J. Semin. Cancer Biol. (2004) [Pubmed]
  25. A hypoxia-driven vascular endothelial growth factor/Flt1 autocrine loop interacts with hypoxia-inducible factor-1alpha through mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 pathway in neuroblastoma. Das, B., Yeger, H., Tsuchida, R., Torkin, R., Gee, M.F., Thorner, P.S., Shibuya, M., Malkin, D., Baruchel, S. Cancer Res. (2005) [Pubmed]
  26. Autocrine signaling through Ras regulates cell survival activity in human glioma cells: potential cross-talk between Ras and the phosphatidylinositol 3-kinase-Akt pathway. Sakata, K., Kato, S., Fox, J.C., Shigemori, M., Morimatsu, M. J. Neuropathol. Exp. Neurol. (2002) [Pubmed]
  27. Autocrine signaling of platelet-derived growth factor regulates disabled-2 expression during megakaryocytic differentiation of K562 cells. Tseng, C.P., Chang, P., Huang, C.L., Cheng, J.C., Chang, S.S. FEBS Lett. (2005) [Pubmed]
  28. Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells. Richards, J.A., Petrel, T.A., Brueggemeier, R.W. J. Steroid Biochem. Mol. Biol. (2002) [Pubmed]
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