The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SLC4A4  -  solute carrier family 4 (sodium...

Bos taurus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on SLC4A4

  • Investigations of corneal endothelium were made to resolve the apparent contradiction of the presence of sodium/bicarbonate cotransporter (NBC) in fresh and cultured cells and NBC's reported absence in isolated plasma membrane vesicles [1].
  • The finding of a novel chloride-activated NBC activity fully resolves the apparent contradiction between whole-cell and membrane vesicle preparations [1].
  • In corneal endothelium, there is evidence for basolateral entry of HCO(3)(-) into corneal endothelial cells via Na(+)-HCO(3)(-) cotransporter (NBC) proteins and for net HCO(3)(-) flux from the basolateral to the apical side [2].
  • Functional studies support the presence of the Na(+)-HCO(3)(-) cotransporter (NBC) in corneal endothelium and possibly corneal epithelium; however, molecular identification and membrane localization have not been reported [3].
  • Two isoforms of NBC have recently been cloned in kidney (kNBC) and pancreas (pNBC) [3].

Anatomical context of SLC4A4


Analytical, diagnostic and therapeutic context of SLC4A4


  1. A chloride-activated Na(+)/HCO(3)(-)-coupled transport activity in corneal endothelial membranes. Lane, J., Wigham, C.G., Hodson, S.A. Biophys. J. (2000) [Pubmed]
  2. Immunocytochemical localization of Na+-HCO3- cotransporters and carbonic anhydrase dependence of fluid transport in corneal endothelial cells. Diecke, F.P., Wen, Q., Sanchez, J.M., Kuang, K., Fischbarg, J. Am. J. Physiol., Cell Physiol. (2004) [Pubmed]
  3. Expression and localization of Na(+)-HCO(3)(-) cotransporter in bovine corneal endothelium. Sun, X.C., Bonanno, J.A., Jelamskii, S., Xie, Q. Am. J. Physiol., Cell Physiol. (2000) [Pubmed]
  4. Insulin binding to human cultured lymphocytes measured by flow cytometry using three ligands. Ziegler, O., Cantin, C., Germain, L., Dupuis, M., Sekaly, R.P., Drouin, P., Chiasson, J.L. Cytometry. (1994) [Pubmed]
WikiGenes - Universities