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Gene Review

GPR34  -  G protein-coupled receptor 34

Homo sapiens

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Disease relevance of GPR34

  • Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1 [1].

High impact information on GPR34

  • Our data show that multiple translation initiation starts and alternative splicing contribute to the supragenomic diversification of GPR34 [2].
  • Directed cloning approaches and large-scale sequencing of several vertebrate genomes unveiled many new members of the G-protein-coupled receptor (GPCR) superfamily, among them GPR34 [2].
  • Combinatory mutagenesis and expression of reporter constructs confirmed these multiple translational start points and revealed a preference for the second in-frame AUG in human GPR34 [2].
  • Deletion screening via Southern blotting and direct sequencing of GPR34 revealed no mutations in 19 unrelated men with CSNB1, excluding a causal role in the disease [1].
  • However, because of its expression in retinal and neural tissue and the involvement of GPCRs in transmembrane signal transduction, GPR34 remains a putative candidate gene for a number of ocular diseases which also map to the Xp11.4 region [1].

Biological context of GPR34


Anatomical context of GPR34

  • These results suggest that GPR34 is the functional mast cell lysoPS receptor [5].
  • Expression of the human GPR34 in COS-7 cells followed by Western blot studies revealed specific bands of a highly glycosylated protein between 75 and 90 kDa [4].

Other interactions of GPR34

  • The receptor encoded by GPR34 is most similar to the P2Y receptor subfamily, while the receptor encoded by GPR44 is most similar to chemoattractant receptors [3].

Analytical, diagnostic and therapeutic context of GPR34


  1. Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1. Jacobi, F.K., Broghammer, M., Pesch, K., Zrenner, E., Berger, W., Meindl, A., Pusch, C.M. Hum. Genet. (2000) [Pubmed]
  2. Genomic and supragenomic structure of the nucleotide-like G-protein-coupled receptor GPR34. Engemaier, E., Römpler, H., Schöneberg, T., Schulz, A. Genomics (2006) [Pubmed]
  3. Discovery of three novel orphan G-protein-coupled receptors. Marchese, A., Sawzdargo, M., Nguyen, T., Cheng, R., Heng, H.H., Nowak, T., Im, D.S., Lynch, K.R., George, S.R., O'dowd, B.F. Genomics (1999) [Pubmed]
  4. A novel subgroup of class I G-protein-coupled receptors. Schöneberg, T., Schulz, A., Grosse, R., Schade, R., Henklein, P., Schultz, G., Gudermann, T. Biochim. Biophys. Acta (1999) [Pubmed]
  5. Identification of a lysophosphatidylserine receptor on mast cells. Sugo, T., Tachimoto, H., Chikatsu, T., Murakami, Y., Kikukawa, Y., Sato, S., Kikuchi, K., Nagi, T., Harada, M., Ogi, K., Ebisawa, M., Mori, M. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
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