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Gene Review

IGKV3D-15  -  immunoglobulin kappa variable 3D-15...

Homo sapiens

Synonyms: IGKV3D15, L16, L16a, L16b, L16c
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Disease relevance of IGKV3D-15

  • This report suggests that megadolichobasilar anomaly is potentially life-threatening, and that L16P is a disease-causing mutation in patients with Fabry's disease [1].
  • The title compounds were evaluated against NSCLCN6 L16 bronchial epidermoid carcinoma in vitro and some of them were found to be active [2].

High impact information on IGKV3D-15

  • When gas3/PMP22 point mutations (L16P, S79C, T118M, and G150D) are similarly overexpressed in NIH-3T3 cells, the induced apoptotic-like phenotype as compared to the wild-type is significantly reduced [3].
  • Expression of IFN-stimulated response element- and gamma-activated sequence-controlled genes was severely impaired in cells infected with RV SAD L16 or in cells expressing RV P protein from transfected plasmids [4].
  • By reverse genetics, we recovered viable RVs in which the strongly attenuating G/L gene border of wild-type (wt) RV (SAD L16) was replaced with N/P-derived gene borders (SAD T and SAD T2) [5].
  • Peptides containing single glycine, serine, alanine, or threonine amino acid substitutions at the buried L9, L16, L23, and I26 hydrophobic core positions of a GCN4-based sequence were synthesized and studied by solution-phase and crystallographic techniques [6].
  • The nucleotide sequences of resistant and susceptible isolates were compared, and a point mutation (thymine to guanine) that causes an Ile52-Ser substitution in ribosomal protein L16 was identified [7].

Biological context of IGKV3D-15

  • Two large polypeptide fragments of ribosomal protein L16 were obtained by limited hydrolysis with trypsin and chymotrypsin [8].
  • We also noted several discrepancies between phylogenetic trees based on 16S rRNA gene sequences and sequences of ribosomal proteins L16, L22 and S14, suggesting that horizontal gene transfer did play a significant role in the evolution of the S10-spc-alpha gene clusters [9].
  • Genetic analysis disclosed a c.47T-->C missense mutation resulting in L16P in the amino acid sequence of the alpha-galactosidase protein [1].
  • Assuming just one high affinity binding site on L16 for anionic lipid, the affinity of the site for di(C18 : 1)PS was calculated to be ca. 8 times that for di (C18 : 1)PC [10].

Anatomical context of IGKV3D-15

  • The latter inhibitors act in substoichiometric concentration (KA = 0.32 X 10(6) M-1) and produce lasting ribosome damage due to a conformational alteration requiring proteins L7/L12, L8 and L16 [11].
  • The binding to neutrophils of a monoclonal anti-LFA-1 antibody (NK1-L16) specific for an activation epitope of CD11a was increased a maximum of 28-fold and sixfold, respectively, after 1 and 5 min of preincubation with 10 nM LTB4 and fivefold after 5 min with PMA [12].

Associations of IGKV3D-15 with chemical compounds

  • Experimental methods based on gas-phase chromatography were tested with a view to determine the gas-liquid n-hexadecane partition coefficients, log L16 of non-volatile compounds at 298.2 K [13].
  • The single histidine in L16 appears to be important in the catalysis of peptide bond formation and transesterification [14].
  • It was demonstrated that reliable values of log L16 of compounds more volatile than n-docosane can be obtained using either capillary, or packed columns [13].
  • The sorption of VOCs as vapors to a typical organobentonite, modified with cetyltrimethylammonium bromide (CTMAB-bentonite), was characterized using a linear solvation energy relationship (LSER) of the type log Kc = c + rR2 + s pi2H + a sigma(alpha2)H + b sigma(beta2)H + l log L16 [15].
  • The peptide Ac-KKGYL6WL8YKKA-amide (Y2L14) incorporated into bilayers of dinervonylphosphatidylcholine [di(C24 : 1)PC] whereas L16 did not incorporate into this lipid [10].


  1. Megadolichobasilar anomaly with thrombosis in a family with Fabry's disease and a novel mutation in the alpha-galactosidase A gene. Garzuly, F., Maródi, L., Erdös, M., Grubits, J., Varga, Z., Gelpi, E., Rohonyi, B., Mázló, M., Molnár, A., Budka, H. Brain (2005) [Pubmed]
  2. Synthesis and antitumor activity of some new 2-chloroethylnitrosoureas. Filippatos, E., Papadaki-Valiraki, A., Roussakis, C., Verbist, J.F. Arch. Pharm. (Weinheim) (1993) [Pubmed]
  3. Apoptotic phenotype induced by overexpression of wild-type gas3/PMP22: its relation to the demyelinating peripheral neuropathy CMT1A. Fabbretti, E., Edomi, P., Brancolini, C., Schneider, C. Genes Dev. (1995) [Pubmed]
  4. Inhibition of interferon signaling by rabies virus phosphoprotein P: activation-dependent binding of STAT1 and STAT2. Brzózka, K., Finke, S., Conzelmann, K.K. J. Virol. (2006) [Pubmed]
  5. Differential transcription attenuation of rabies virus genes by intergenic regions: generation of recombinant viruses overexpressing the polymerase gene. Finke, S., Cox, J.H., Conzelmann, K.K. J. Virol. (2000) [Pubmed]
  6. Structure-based engineering of internal cavities in coiled-coil peptides. Yadav, M.K., Redman, J.E., Leman, L.J., Alvarez-Gutiérrez, J.M., Zhang, Y., Stout, C.D., Ghadiri, M.R. Biochemistry (2005) [Pubmed]
  7. Mutations in ribosomal protein L16 conferring reduced susceptibility to evernimicin (SCH27899): implications for mechanism of action. Adrian, P.V., Zhao, W., Black, T.A., Shaw, K.J., Hare, R.S., Klugman, K.P. Antimicrob. Agents Chemother. (2000) [Pubmed]
  8. The role of protein L16 and its fragments in the peptidyltransferase activity of 50-S ribosomal subunits. Maimets, T., Ustav, M., Villems, R. Eur. J. Biochem. (1983) [Pubmed]
  9. Organisation of the S10, spc and alpha ribosomal protein gene clusters in prokaryotic genomes. Coenye, T., Vandamme, P. FEMS Microbiol. Lett. (2005) [Pubmed]
  10. Lipid-protein interactions in the membrane: studies with model peptides. Mall, S., Sharma, R.P., East, J.M., Lee, A.G. Faraday Discuss. (1998) [Pubmed]
  11. Molecular mechanism of action of virginiamycin-like antibiotics (synergimycins) on protein synthesis in bacterial cell-free systems. Cocito, C., Chinali, G. J. Antimicrob. Chemother. (1985) [Pubmed]
  12. Activation of human neutrophil LFA-1 (CD11a) by leukotriene B4. Shames, R.S., Goetzl, E.J. Inflammation (1993) [Pubmed]
  13. Experimental determination and prediction of the gas-liquid n-hexadecane partition coefficients. Mutelet, F., Rogalski, M. Journal of chromatography. A. (2001) [Pubmed]
  14. L16, a bifunctional ribosomal protein and the enhancing effect of L6 and L11. Baxter, R.M., Zahid, N. Eur. J. Biochem. (1986) [Pubmed]
  15. Characterization of sorption mechanisms of VOCs with organobentonites using a LSER approach. Tian, S., Zhu, L., Shi, Y. Environ. Sci. Technol. (2004) [Pubmed]
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