Disease relevance of IGKV6-21

• We are presently attempting to determine the genes that code tumor rejection antigens recognized by HLA-A24- and A26-restricted T cells, including those of pulmonary and pancreatic carcinomas [1].
• Analysis of the primary concordant HIV+ and discordant HIV+ individuals showed a marked increase in the prevalence of B44 in the Hispanic discordant seropositives, whereas the Caucasian primary concordants had a marked increase in the prevalence of A26 [2].
• The locus A26, which seems to be a genetic marker of pemphigus, was detected in his haplotype [3].
• METHODS: A 26-month-old boy developed oral thrush and painless right proptosis with eyelid swelling [4].
• This virus also had DNA restriction profiles identical to those of the reference CAV-2 (Toronto A26/61), whereas previously isolated strains of adenovirus from dogs in New Zealand had DNA restriction patterns identical to the prototype CAV-1 strain (Utrecht) [5].

High impact information on IGKV6-21

• Identification of a novel human leukocyte antigen A26-restricted epitope in a conserved region of Gag [6].
• By analysis of the locations of rAMPS residues in cleavage products derived from partially rATP alpha S-substituted oligoribonucleotides, we identified A26 as the residue contributing the non-junction phosphorothioate diester that most strongly inhibited self-cleavage [7].
• To fix the distance between the C-terminal end of the A chain and Trp (B27) at predetermined lengths, we synthesized RLF with covalent cross-links between a lysine, which was placed in position B26, and the alpha-carboxyl group at the C terminus of the A chain (A26) [8].
• Evidence was obtained for the presence of a non-Watson-Crick base pair between A26 and G36 in the catalytic conformation of the hairpin ribozyme [9].
• Fructose 1,6-bisphosphate aldolase, Sm21.7, the proteasome homologue and 1 unknown clone (A26) have been expressed in a bacterial expression system and serum produced against each recombinant protein [10].

Biological context of IGKV6-21

• Nucleotide sequencing of the A26 allele has been performed, and the deduced amino acid sequence was compared with previously published HLA class I sequences [11].
• Corneal graft survival was similar when one or two A26, B35 or B44 alleles were present on the donor cornea [12].

Anatomical context of IGKV6-21

• Immunolocalization showed fructose 1,6-bisphosphate aldolase, Sm21.7 and the proteasome homologue to be most abundant in muscle cells whilst clone A26 was distributed throughout many tissues, but was most abundant in the tegument [10].
• The SART1(259) antigen is recognized by HLA-A24 and A26-restricted cytotoxic T lymphocytes (CTLs) [13].

Associations of IGKV6-21 with chemical compounds

• The rare Oriental variant of A26 (A26v*) is encoded by an allele (A*2602) that differs from A*2601 by a unique nucleotide substitution which changes aspartate to asparagine at position 116 in the floor of the peptide binding groove [14].
• A26.4 (A*2603) was different from the other A26 splits at three positions: 74 histidine, 76 valine, and 77 aspartate [15].
• Regarding the HLA typing, A26, B35 and C3 were positive in all 3 patients [16].

Analytical, diagnostic and therapeutic context of IGKV6-21

• HLA typing detected the same antigens in both twins: A1, A26, B8, B17, DR3, DR7 [17].

References