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CAV1  -  caveolin 1, caveolae protein, 22kDa

Canis lupus familiaris

 
 
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Disease relevance of CAV1

  • CAV-1 DNA or antigens were not detected by either technique in any of the 45 cases of chronic liver disease selected for the study [1].
  • Serum antibody titers to canine parvovirus (CPV), canine adenovirus-1 (CAV-1), and canine distemper virus (CDV) were measured in dogs with known immunization status [2].
  • Formalin-fixed, paraffin-embedded liver sections of 2 cases of infectious canine hepatitis (ICH) and crude DNA extract from CAV-1 (ATCC VR 293 Utrecht strain) served as positive controls [1].
  • To assess the possible involvement of canine adenovirus type 1 (CAV-1) in naturally occurring cases of canine chronic liver disease, a polymerase chain reaction (PCR)-based assay was developed to detect a conserved region of the major core protein gene (pVII) of CAV-1 in formalin-fixed, paraffin-embedded liver sections [1].
  • These data, along with other evidence from the literature, suggest that not only should CAV-1 and CAV-2 be recognized as distinct species in the genus mastadenovirus of the family Adenoviridae, but also that the major criterion of species distinction in that family, namely neutralization, should be reconsidered [3].
 

High impact information on CAV1

  • A second construct, containing a different promoter, showed delayed growth and genome instability which, based on the size difference between these inserts, suggests a maximum packaging size of 106 to 109% wild-type genome size for CAV-1 [4].
  • RESULTS: The percentage of dogs that had titers at or greater than the threshold values or responded to revaccination with a > or = 4-fold increase in titer was 98.1% for CDV, 98.4% for CAV-1, 99.0% for CAV-2, 100% for CPIV, and 98.1% for CPV [5].
  • PROCEDURE: Dogs were > or = 2 years old and vaccinated against canine distemper virus (CDV), canine adenovirus-1 (CAV-1), canine adenovirus-2 (CAV-2), canine parainfluenza virus (CPIV), and canine parvovirus (CPV) [5].
  • These results indicate that both PCR and immunohistochemistry are reliable and rapid techniques for detecting CAV-1 in formalin-fixed, paraffin-embedded liver sections of dogs with ICH [1].
  • A 411-base-pair viral region was amplified and sequenced as CAV-1 pVII in both cases of infectious canine hepatitis and in the CAV-1 crude DNA extract [1].
 

Biological context of CAV1

  • Dogs were considered to have responded serologically if they had a day-0 serum neutralization titer to CDV > or = 1:32; a serum neutralization titer to CAV-1, CAV-2, or CPIV > or = 1:16; a hemagglutination inhibition titer to CPV > or = 1:80; or a > or = 4-fold increase in antibody titer after revaccination [5].
 

Anatomical context of CAV1

 

Regulatory relationships of CAV1

  • The fraction of dogs with CAV-1 antibody titres > or = 1:16 was significantly greater in the group that received inactivated CAV-1 vaccine than in the group vaccinated with attenuated live CAV-2 vaccine [8].
 

Analytical, diagnostic and therapeutic context of CAV1

  • The concentration of maternal antibody seemed to be of major importance for failure of immunization with use of inactivated CPV vaccine, but not with CAV-1 and CDV vaccination [2].
  • 18 of 36 monoclonal antibodies from the CAV-1 fusion and 77 of 160 monoclonal antibodies from the CAV-2 fusion were type-specific by an indirect fluorescent-antibody technique [3].
  • Seroprevalence in C. adustus and C. mesomelas respectively were 50% and 63.6% for CDV, 12.5% and 18.2% for CPV and 37.5 and 9.1 for CAV-1 [9].

References

  1. Use of polymerase chain reaction and immunohistochemistry for detection of canine adenovirus type 1 in formalin-fixed, paraffin-embedded liver of dogs with chronic hepatitis or cirrhosis. Chouinard, L., Martineau, D., Forget, C., Girard, C. J. Vet. Diagn. Invest. (1998) [Pubmed]
  2. Serum antibody response to canine parvovirus, canine adenovirus-1, and canine distemper virus in dogs with known status of immunization: study of dogs in Sweden. Olson, P., Klingeborn, B., Hedhammar, A. Am. J. Vet. Res. (1988) [Pubmed]
  3. Should the criteria for species distinction in adenoviruses be reconsidered? Evidence from canine adenoviruses 1 and 2. Whetstone, C.A. Intervirology (1985) [Pubmed]
  4. Generation of E3-deleted canine adenoviruses expressing canine parvovirus capsid by homologous recombination in bacteria. Morrison, M.D., Reid, D., Onions, D., Spibey, N., Nicolson, L. Virology (2002) [Pubmed]
  5. Duration of serologic response to five viral antigens in dogs. Mouzin, D.E., Lorenzen, M.J., Haworth, J.D., King, V.L. J. Am. Vet. Med. Assoc. (2004) [Pubmed]
  6. Characterization of the genome of a vaccine strain of canine adenovirus type 1. Liu, Y.C., Abouhaidar, M.G., Sira, S., Campbell, J.B. Virus Genes (1988) [Pubmed]
  7. Viral-antibody complexes in canine adenovirus type 1 (CAV-1)ocular lesions: leukocyte chemotaxis and enzyme release. Carmichael, L.E., Medic, B.L., Bistner, S.I., Aguirre, G.D. The Cornell veterinarian. (1975) [Pubmed]
  8. Canine parvovirus infection, canine distemper and infectious canine hepatitis: inclination to vaccinate and antibody response in the Swedish dog population. Olson, P., Hedhammar, A., Klingeborn, B. Acta Vet. Scand. (1996) [Pubmed]
  9. Presence of antibodies to canine distemper virus, canine parvovirus and canine adenovirus type 1 in free-ranging jackals (Canis adustus and Canis mesomelas) in Zimbabwe. Spencer, J.A., Bingham, J., Heath, R., Richards, B. Onderstepoort J. Vet. Res. (1999) [Pubmed]
 
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