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Gene Review:

Plcg2 - phospholipase C, gamma 2

Rattus norvegicus

Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, PLC-IV, PLC-gamma-2, Phosphoinositide phospholipase C-gamma-2, Phospholipase C-IV, ...

Emori, Y. et al., Atkinson, T.P. et al., Homma, Y. et al., Zhang, J. et al., Atkinson, T.P. et al., et al.

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Disease relevance of Plcg2

Using an Escherichia coli expression system, we succeeded in producing active PLC IV in E. coli crude extracts [1].

High impact information on Plcg2

In these reconstituted cells, Fc epsilon RI aggregation induced tyrosine phosphorylation of phospholipase C-gamma 1 and phospholipase C-gamma 2, an increase in intracellular free Ca2+ and histamine release [2].
In addition, incubation of RBL cells with either oligomeric IgE or orthovanadate results in the translocation of PLC-gamma 2 from the cytosol to the particulate fraction [3].
Isolation and characterization of rat 3Y1 fibroblast clones overexpressing the src homology region of phospholipase C-gamma 2 [4].
A fourth type of rat phosphoinositide-specific phospholipase C (PLC IV) has been cloned for cDNA and sequenced [1].
PLC IV is distinct from the other three types of rat PLC (PLC I, II, and III) with respect to primary structure and tissue distribution of its mRNAs [1].

Biological context of Plcg2

PLC IV, in common with PLC II, has a sequence homologous to the N-terminal regulatory domains of nonreceptor tyrosine kinases of the src-family of oncogenes [1].
The substrate specificity of phosphoinositide-phospholipase C in rat heart sarcolemma [5].

Anatomical context of Plcg2

Translocation of phospholipase C-gamma 2 induced by in vitro activation of protein tyrosine kinase activity in mast cell lysates [6].
PLC gamma 2 mRNA was localized only in the Purkinje and granule cells in the vermal portions of lobules IX and X of the cerebellum, and in the adenohypophysis [7].

Associations of Plcg2 with chemical compounds

Both tyrosine phosphorylation and PLC gamma 2 translocation are inhibited by genistein [6].
We determined the effect of purified rP45Z or rP38Z on PIP2-hydrolyzing activity of either PLC-gamma 1 or PLC-gamma 2 and found that these proteins strongly suppressed the rate of PLC-dependent PIP2-hydrolysis [8].

Other interactions of Plcg2

On the other hand, PLC-beta 4, PLC-gamma 1 and PLC-gamma 2 were distributed almost equally among the regions for the rats of both ages [9].

References

A second type of rat phosphoinositide-specific phospholipase C containing a src-related sequence not essential for phosphoinositide-hydrolyzing activity. Emori, Y., Homma, Y., Sorimachi, H., Kawasaki, H., Nakanishi, O., Suzuki, K., Takenawa, T. J. Biol. Chem. (1989) [Pubmed]
Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells. Zhang, J., Berenstein, E.H., Evans, R.L., Siraganian, R.P. J. Exp. Med. (1996) [Pubmed]
Orthovanadate induces translocation of phospholipase C-gamma 1 and -gamma 2 in permeabilized mast cells. Atkinson, T.P., Lee, C.W., Rhee, S.G., Hohman, R.J. J. Immunol. (1993) [Pubmed]
Isolation and characterization of rat 3Y1 fibroblast clones overexpressing the src homology region of phospholipase C-gamma 2. Homma, Y., Emori, Y., Takenawa, T. J. Biol. Chem. (1992) [Pubmed]
The substrate specificity of phosphoinositide-phospholipase C in rat heart sarcolemma. Meij, J.T., Panagia, V. Mol. Cell. Biochem. (1992) [Pubmed]
Translocation of phospholipase C-gamma 2 induced by in vitro activation of protein tyrosine kinase activity in mast cell lysates. Atkinson, T.P., Yang, Q. Cell. Signal. (1996) [Pubmed]
Localization of mRNAs for three novel members (beta 3, beta 4 and gamma 2) of phospholipase C family in mature rat brain. Tanaka, O., Kondo, H. Neurosci. Lett. (1994) [Pubmed]
Purification of recombinant SH2/SH3 proteins of phospholipase C-gamma 1 and -gamma 2 and their inhibitory effect on PIP2-hydrolysis induced by both types of phospholipase C-gamma. Homma, Y., Emori, Y., Takenawa, T. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
Attenuation of renomedullary phospholipase C isozyme, PLC-delta 1, in spontaneously hypertensive rats. Lee, K.H., Cho, Y.J., Cha, S.H., Endou, H. Biochem. Mol. Biol. Int. (1997) [Pubmed]

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