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Gene Review

Plcb4  -  phospholipase C, beta 4

Rattus norvegicus

Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4, Beta4aa, PLC-beta-4, Phosphoinositide phospholipase C-beta-4, Phospholipase C-beta-4, ...
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Disease relevance of Plcb4

  • Antisense constructs, consisting of the cytomegalovirus promoter driving antisense cRNA corresponding to the 3'-untranslated regions of PLC-beta1 and PLC-beta4, were injected into the nucleus of dissociated SCG neurons [1].

High impact information on Plcb4


Biological context of Plcb4

  • The different carboxyl terminal tails of PLCbeta4 isoforms may allow for differential targeting and subcellular localization, contributing to regulation of PLC beta4-mediated signal transduction [5].
  • BK inhibition of I(K(M)) was significantly reduced 48 hr after injection of the PLC-beta4, but not the PLC-beta1, antisense-encoding plasmid [1].

Anatomical context of Plcb4


Other interactions of Plcb4


Analytical, diagnostic and therapeutic context of Plcb4


  1. Bradykinin, but not muscarinic, inhibition of M-current in rat sympathetic ganglion neurons involves phospholipase C-beta 4. Haley, J.E., Abogadie, F.C., Fernandez-Fernandez, J.M., Dayrell, M., Vallis, Y., Buckley, N.J., Brown, D.A. J. Neurosci. (2000) [Pubmed]
  2. A cytosolic, galphaq- and betagamma-insensitive splice variant of phospholipase C-beta4. Kim, M.J., Min, D.S., Ryu, S.H., Suh, P.G. J. Biol. Chem. (1998) [Pubmed]
  3. Stimulation of G-protein coupled receptors in vascular smooth muscle cells induces tyrosine kinase dependent increases in calcium without tyrosine phosphorylation of phospholipase C gamma-1. Di Salvo, J., Raatz Nelson, S. FEBS Lett. (1998) [Pubmed]
  4. Immunological characterization of 130 kDa phospholipase C-beta 4 isozyme in rat cerebellar Purkinje cells. Min, D.S., Kim, M.J., Jeong, H.K., Lee, Y.H., Kim, H., Shin, H.S., Ryu, S.H., Suh, P.G. Neurosci. Lett. (2000) [Pubmed]
  5. A unique isoform of phospholipase Cbeta4 highly expressed in the cerebellum and eye. Adamski, F.M., Timms, K.M., Shieh, B.H. Biochim. Biophys. Acta (1999) [Pubmed]
  6. Pancreastatin activates beta3 isoform of phospholipase C via G(alpha)11 protein stimulation in rat liver membranes. Santos-Alvarez, J., Sánchez-Margalet, V. Mol. Cell. Endocrinol. (1998) [Pubmed]
  7. Localization of mRNAs for three novel members (beta 3, beta 4 and gamma 2) of phospholipase C family in mature rat brain. Tanaka, O., Kondo, H. Neurosci. Lett. (1994) [Pubmed]
  8. Endothelin inhibits the calcium pump and stimulates phosphoinositide phospholipase C in liver plasma membranes via two different G proteins, Gs and Gq. Jouneaux, C., Goldsmith, P., Hanoune, J., Lotersztajn, S. J. Cardiovasc. Pharmacol. (1993) [Pubmed]
  9. Attenuation of renomedullary phospholipase C isozyme, PLC-delta 1, in spontaneously hypertensive rats. Lee, K.H., Cho, Y.J., Cha, S.H., Endou, H. Biochem. Mol. Biol. Int. (1997) [Pubmed]
  10. Purification, molecular cloning, and sequencing of phospholipase C-beta 4. Lee, C.W., Park, D.J., Lee, K.H., Kim, C.G., Rhee, S.G. J. Biol. Chem. (1993) [Pubmed]
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