The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Plcg1  -  phospholipase C, gamma 1

Rattus norvegicus

Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, PLC-gamma-1, Phosphoinositide phospholipase C-gamma-1, Phospholipase C-gamma-1
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Plcg1

 

Psychiatry related information on Plcg1

 

High impact information on Plcg1

 

Chemical compound and disease context of Plcg1

 

Biological context of Plcg1

 

Anatomical context of Plcg1

 

Associations of Plcg1 with chemical compounds

 

Physical interactions of Plcg1

  • Based on these results, we propose that PLC-beta and PLC-gamma isozymes form signaling complexes with ERK2 in rat brain, and these complexes play critical roles in learning and memory, as well as a variety of other neuronal functions [21].
 

Enzymatic interactions of Plcg1

 

Regulatory relationships of Plcg1

 

Other interactions of Plcg1

 

Analytical, diagnostic and therapeutic context of Plcg1

References

  1. Patterns of tyrosine phosphorylation differ in vascular hypertrophy and hyperplasia. Ali, S., Dorn, G.W. Am. J. Physiol. (1994) [Pubmed]
  2. Baculovirus expression and purification of the second messenger enzyme phospholipase C-gamma 1, a tyrosine kinase substrate. Horstman, D.A., Ball, R., Carpenter, G. Protein Expr. Purif. (1995) [Pubmed]
  3. Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity. Bai, R.Y., Dieter, P., Peschel, C., Morris, S.W., Duyster, J. Mol. Cell. Biol. (1998) [Pubmed]
  4. Pertussis toxin-sensitive Gi protein involvement in epidermal growth factor-induced activation of phospholipase C-gamma in rat hepatocytes. Yang, L.J., Baffy, G., Rhee, S.G., Manning, D., Hansen, C.A., Williamson, J.R. J. Biol. Chem. (1991) [Pubmed]
  5. Orthovanadate induces translocation of phospholipase C-gamma 1 and -gamma 2 in permeabilized mast cells. Atkinson, T.P., Lee, C.W., Rhee, S.G., Hohman, R.J. J. Immunol. (1993) [Pubmed]
  6. Phospholipase C gamma in distinct regions of the ventral tegmental area differentially regulates morphine-induced locomotor activity. Bolaños, C.A., Neve, R.L., Nestler, E.J. Synapse (2005) [Pubmed]
  7. Tyrosine phosphorylation of PLC-gamma 1 induced by electroconvulsive shock in rat hippocampus. Lee, Y.H., Ryu, S.H., Suh, P.G., Park, J.B., Ahn, Y.M., Kim, Y.S. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  8. SH3 domains direct cellular localization of signaling molecules. Bar-Sagi, D., Rotin, D., Batzer, A., Mandiyan, V., Schlessinger, J. Cell (1993) [Pubmed]
  9. Cloning and sequence of multiple forms of phospholipase C. Suh, P.G., Ryu, S.H., Moon, K.H., Suh, H.W., Rhee, S.G. Cell (1988) [Pubmed]
  10. Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis. Mohammadi, M., Dionne, C.A., Li, W., Li, N., Spivak, T., Honegger, A.M., Jaye, M., Schlessinger, J. Nature (1992) [Pubmed]
  11. Beta PDGF receptor mutants defective for mitogenesis promote neurite outgrowth in PC12 cells. Vetter, M.L., Bishop, J.M. Curr. Biol. (1995) [Pubmed]
  12. A PI3K Pathway Mediates Hair Cell Survival and Opposes Gentamicin Toxicity in Neonatal Rat Organ of Corti. Chung, W.H., Pak, K., Lin, B., Webster, N., Ryan, A.F. J. Assoc. Res. Otolaryngol. (2006) [Pubmed]
  13. Identification of TrkB autophosphorylation sites and evidence that phospholipase C-gamma 1 is a substrate of the TrkB receptor. Middlemas, D.S., Meisenhelder, J., Hunter, T. J. Biol. Chem. (1994) [Pubmed]
  14. Ontogenic regulation of phospholipase C-gamma 1 activity and expression in the rat small intestine. Polk, D.B. Gastroenterology (1994) [Pubmed]
  15. Nerve growth factor stimulates phosphorylation of phospholipase C-gamma in PC12 cells. Kim, U.H., Fink, D., Kim, H.S., Park, D.J., Contreras, M.L., Guroff, G., Rhee, S.G. J. Biol. Chem. (1991) [Pubmed]
  16. Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma 1 in vascular smooth muscle cells. Marrero, M.B., Paxton, W.G., Duff, J.L., Berk, B.C., Bernstein, K.E. J. Biol. Chem. (1994) [Pubmed]
  17. Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin. Kayali, A.G., Eichhorn, J., Haruta, T., Morris, A.J., Nelson, J.G., Vollenweider, P., Olefsky, J.M., Webster, N.J. J. Biol. Chem. (1998) [Pubmed]
  18. Temporal dispersion of activation of phospholipase C-beta1 and -gamma isoforms by angiotensin II in vascular smooth muscle cells. Role of alphaq/11, alpha12, and beta gamma G protein subunits. Ushio-Fukai, M., Griendling, K.K., Akers, M., Lyons, P.R., Alexander, R.W. J. Biol. Chem. (1998) [Pubmed]
  19. Phosphorylation of phospholipase C-gamma by cAMP-dependent protein kinase. Kim, U.H., Kim, J.W., Rhee, S.G. J. Biol. Chem. (1989) [Pubmed]
  20. Phospholipase C beta and membrane action of calcitriol and estradiol. Le Mellay, V., Grosse, B., Lieberherr, M. J. Biol. Chem. (1997) [Pubmed]
  21. Fear conditioning is associated with altered integration of PLC and ERK signaling in the hippocampus. Buckley, C.T., Caldwell, K.K. Pharmacol. Biochem. Behav. (2004) [Pubmed]
  22. Angiotensin II activates pp60c-src in vascular smooth muscle cells. Ishida, M., Marrero, M.B., Schieffer, B., Ishida, T., Bernstein, K.E., Berk, B.C. Circ. Res. (1995) [Pubmed]
  23. Stimulation of G-protein coupled receptors in vascular smooth muscle cells induces tyrosine kinase dependent increases in calcium without tyrosine phosphorylation of phospholipase C gamma-1. Di Salvo, J., Raatz Nelson, S. FEBS Lett. (1998) [Pubmed]
  24. Phosphatidylinositol 3-kinase activation is required for sulfonylurea stimulation of glucose transport in rat skeletal muscle. Rodríguez, E., Pulido, N., Romero, R., Arrieta, F., Panadero, A., Rovira, A. Endocrinology (2004) [Pubmed]
  25. Cooperation of thyrotropin, but not basic fibroblast growth factor, with an adenosine receptor agonist in Ca2+ mobilization from thapsigargin-sensitive pools in single FRTL-5 thyroid cells. Sho, K., Okajima, F., Kondo, Y. Endocrinology (1995) [Pubmed]
  26. Gastrin induces IP3 formation through phospholipase C gamma 1 and pp60c-src kinase. Yassin, R.R., Abrams, J.T. Peptides (1998) [Pubmed]
  27. Assignment of the rat phospholipase C-gamma1 gene Plcg1 to rat chromosome band 3q42 by fluorescence in situ hybridization. Park, S.H., Suh, P.G., Ryu, S.H., Kim, H. Cytogenet. Cell Genet. (1999) [Pubmed]
  28. Immunocytochemical localization of phospholipase C-gamma in rat embryo fibroblasts. McBride, K., Rhee, S.G., Jaken, S. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  29. Phospholipase C-gamma 1 associates with viral and cellular src kinases. Nakanishi, O., Shibasaki, F., Hidaka, M., Homma, Y., Takenawa, T. J. Biol. Chem. (1993) [Pubmed]
  30. Endotoxin tolerance alters phospholipase C-gamma 1 and phosphatidylinositol-3'-kinase expression in peritoneal macrophages. Bowling, W.M., Hafenrichter, D.G., Flye, M.W., Callery, M.P. J. Surg. Res. (1995) [Pubmed]
 
WikiGenes - Universities