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Gene Review

Plcg1  -  phospholipase C, gamma 1

Rattus norvegicus

Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, PLC-gamma-1, Phosphoinositide phospholipase C-gamma-1, Phospholipase C-gamma-1
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Disease relevance of Plcg1


Psychiatry related information on Plcg1


High impact information on Plcg1


Chemical compound and disease context of Plcg1


Biological context of Plcg1


Anatomical context of Plcg1


Associations of Plcg1 with chemical compounds


Physical interactions of Plcg1

  • Based on these results, we propose that PLC-beta and PLC-gamma isozymes form signaling complexes with ERK2 in rat brain, and these complexes play critical roles in learning and memory, as well as a variety of other neuronal functions [21].

Enzymatic interactions of Plcg1


Regulatory relationships of Plcg1


Other interactions of Plcg1


Analytical, diagnostic and therapeutic context of Plcg1


  1. Patterns of tyrosine phosphorylation differ in vascular hypertrophy and hyperplasia. Ali, S., Dorn, G.W. Am. J. Physiol. (1994) [Pubmed]
  2. Baculovirus expression and purification of the second messenger enzyme phospholipase C-gamma 1, a tyrosine kinase substrate. Horstman, D.A., Ball, R., Carpenter, G. Protein Expr. Purif. (1995) [Pubmed]
  3. Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity. Bai, R.Y., Dieter, P., Peschel, C., Morris, S.W., Duyster, J. Mol. Cell. Biol. (1998) [Pubmed]
  4. Pertussis toxin-sensitive Gi protein involvement in epidermal growth factor-induced activation of phospholipase C-gamma in rat hepatocytes. Yang, L.J., Baffy, G., Rhee, S.G., Manning, D., Hansen, C.A., Williamson, J.R. J. Biol. Chem. (1991) [Pubmed]
  5. Orthovanadate induces translocation of phospholipase C-gamma 1 and -gamma 2 in permeabilized mast cells. Atkinson, T.P., Lee, C.W., Rhee, S.G., Hohman, R.J. J. Immunol. (1993) [Pubmed]
  6. Phospholipase C gamma in distinct regions of the ventral tegmental area differentially regulates morphine-induced locomotor activity. Bolaños, C.A., Neve, R.L., Nestler, E.J. Synapse (2005) [Pubmed]
  7. Tyrosine phosphorylation of PLC-gamma 1 induced by electroconvulsive shock in rat hippocampus. Lee, Y.H., Ryu, S.H., Suh, P.G., Park, J.B., Ahn, Y.M., Kim, Y.S. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  8. SH3 domains direct cellular localization of signaling molecules. Bar-Sagi, D., Rotin, D., Batzer, A., Mandiyan, V., Schlessinger, J. Cell (1993) [Pubmed]
  9. Cloning and sequence of multiple forms of phospholipase C. Suh, P.G., Ryu, S.H., Moon, K.H., Suh, H.W., Rhee, S.G. Cell (1988) [Pubmed]
  10. Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis. Mohammadi, M., Dionne, C.A., Li, W., Li, N., Spivak, T., Honegger, A.M., Jaye, M., Schlessinger, J. Nature (1992) [Pubmed]
  11. Beta PDGF receptor mutants defective for mitogenesis promote neurite outgrowth in PC12 cells. Vetter, M.L., Bishop, J.M. Curr. Biol. (1995) [Pubmed]
  12. A PI3K Pathway Mediates Hair Cell Survival and Opposes Gentamicin Toxicity in Neonatal Rat Organ of Corti. Chung, W.H., Pak, K., Lin, B., Webster, N., Ryan, A.F. J. Assoc. Res. Otolaryngol. (2006) [Pubmed]
  13. Identification of TrkB autophosphorylation sites and evidence that phospholipase C-gamma 1 is a substrate of the TrkB receptor. Middlemas, D.S., Meisenhelder, J., Hunter, T. J. Biol. Chem. (1994) [Pubmed]
  14. Ontogenic regulation of phospholipase C-gamma 1 activity and expression in the rat small intestine. Polk, D.B. Gastroenterology (1994) [Pubmed]
  15. Nerve growth factor stimulates phosphorylation of phospholipase C-gamma in PC12 cells. Kim, U.H., Fink, D., Kim, H.S., Park, D.J., Contreras, M.L., Guroff, G., Rhee, S.G. J. Biol. Chem. (1991) [Pubmed]
  16. Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma 1 in vascular smooth muscle cells. Marrero, M.B., Paxton, W.G., Duff, J.L., Berk, B.C., Bernstein, K.E. J. Biol. Chem. (1994) [Pubmed]
  17. Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin. Kayali, A.G., Eichhorn, J., Haruta, T., Morris, A.J., Nelson, J.G., Vollenweider, P., Olefsky, J.M., Webster, N.J. J. Biol. Chem. (1998) [Pubmed]
  18. Temporal dispersion of activation of phospholipase C-beta1 and -gamma isoforms by angiotensin II in vascular smooth muscle cells. Role of alphaq/11, alpha12, and beta gamma G protein subunits. Ushio-Fukai, M., Griendling, K.K., Akers, M., Lyons, P.R., Alexander, R.W. J. Biol. Chem. (1998) [Pubmed]
  19. Phosphorylation of phospholipase C-gamma by cAMP-dependent protein kinase. Kim, U.H., Kim, J.W., Rhee, S.G. J. Biol. Chem. (1989) [Pubmed]
  20. Phospholipase C beta and membrane action of calcitriol and estradiol. Le Mellay, V., Grosse, B., Lieberherr, M. J. Biol. Chem. (1997) [Pubmed]
  21. Fear conditioning is associated with altered integration of PLC and ERK signaling in the hippocampus. Buckley, C.T., Caldwell, K.K. Pharmacol. Biochem. Behav. (2004) [Pubmed]
  22. Angiotensin II activates pp60c-src in vascular smooth muscle cells. Ishida, M., Marrero, M.B., Schieffer, B., Ishida, T., Bernstein, K.E., Berk, B.C. Circ. Res. (1995) [Pubmed]
  23. Stimulation of G-protein coupled receptors in vascular smooth muscle cells induces tyrosine kinase dependent increases in calcium without tyrosine phosphorylation of phospholipase C gamma-1. Di Salvo, J., Raatz Nelson, S. FEBS Lett. (1998) [Pubmed]
  24. Phosphatidylinositol 3-kinase activation is required for sulfonylurea stimulation of glucose transport in rat skeletal muscle. Rodríguez, E., Pulido, N., Romero, R., Arrieta, F., Panadero, A., Rovira, A. Endocrinology (2004) [Pubmed]
  25. Cooperation of thyrotropin, but not basic fibroblast growth factor, with an adenosine receptor agonist in Ca2+ mobilization from thapsigargin-sensitive pools in single FRTL-5 thyroid cells. Sho, K., Okajima, F., Kondo, Y. Endocrinology (1995) [Pubmed]
  26. Gastrin induces IP3 formation through phospholipase C gamma 1 and pp60c-src kinase. Yassin, R.R., Abrams, J.T. Peptides (1998) [Pubmed]
  27. Assignment of the rat phospholipase C-gamma1 gene Plcg1 to rat chromosome band 3q42 by fluorescence in situ hybridization. Park, S.H., Suh, P.G., Ryu, S.H., Kim, H. Cytogenet. Cell Genet. (1999) [Pubmed]
  28. Immunocytochemical localization of phospholipase C-gamma in rat embryo fibroblasts. McBride, K., Rhee, S.G., Jaken, S. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  29. Phospholipase C-gamma 1 associates with viral and cellular src kinases. Nakanishi, O., Shibasaki, F., Hidaka, M., Homma, Y., Takenawa, T. J. Biol. Chem. (1993) [Pubmed]
  30. Endotoxin tolerance alters phospholipase C-gamma 1 and phosphatidylinositol-3'-kinase expression in peritoneal macrophages. Bowling, W.M., Hafenrichter, D.G., Flye, M.W., Callery, M.P. J. Surg. Res. (1995) [Pubmed]
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