High impact information on tnc

• Overexpressing an axon repellent fragment containing the cysteine-rich region and the epidermal growth factor-like repeats of tenascin-C led to retarded growth of ventral motor nerves between their spinal exit point and the horizontal myoseptum [1].
• Tenascin-C was neither expressed in the optic tectum of untrained fish nor in the tectum of learners [2].
• To investigate the involvement of the cell adhesion molecules L1.1, L1.2, NCAM, and tenascin-C in memory formation, zebrafish (Brachydanio rerio) were trained in an active avoidance paradigm to cross a hurdle to avoid mild electric shocks after a light signal [2].
• Specifically, we have mapped the distribution of the transcription factor engrailed, of a chondrotin sulfate epitope, and of the recognition molecules zebrafish semaphorin z1b and zebrafish tenascin C [3].
• Tenascin-C mRNA was detected in neural crest cells during the period of their migration and differentiation [4].

Biological context of tnc

• These expression patterns suggest that tenascin-C may play a role in neural crest cell migration and during the differentiation of neural crest, placodal, and mesodermal derivatives [4].
• A partial zebrafish tenascin-C cDNA clone was isolated from an embryonic zebrafish cDNA library on the basis of homology to mouse tenascin-C [4].
• The function and the regulation of the expression of the extracellular matrix molecule tenascin-C during embryonic development are still unclear [5].

Anatomical context of tnc

• Additionally, expression of tenascin-C mRNA was detected in the hypothalamus and in the developing epiphysis [4].
• The observations demonstrate that an unaccustomed increase of rat soleus muscle loading causes modification of the basement membrane of damaged muscle fibers through ectopic endomysial expression of tenascin-C [6].
• Reloading of atrophied rat soleus muscle induces tenascin-C expression around damaged muscle fibers [6].
• The hypothesis was tested that mechanical loading, induced by hindlimb suspension and subsequent reloading, affects expression of the basement membrane components tenascin-C and fibronectin in the belly portion of rat soleus muscle [6].

Associations of tnc with chemical compounds

• The pathway of the CaP axon and the distribution of the putative neural crest and sclerotome cells correlated with a subdivision of the myotome into an anterior and posterior components, which were evident at the histological level and by the expression of the markers engrailed, semaphorin z1b, chondroitin sulfate, and tenascin C [3].

Other interactions of tnc

• Tenascin-C expression in the trunk of wild-type, cyclops and floating head zebrafish embryos [5].

References