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Gene Review

myog  -  myogenin

Danio rerio

Synonyms: SO:0000704, cb553, zgc:100763
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High impact information on myog

  • Characterization of a muscle-specific enhancer in human MuSK promoter reveals the essential role of myogenin in controlling activity-dependent gene regulation [1].
  • DEAB reduces expression of the myogenic markers myoD and myogenin in somites, whereas RA induces increased expression of these genes and strongly induces premature myoD expression in the presomitic mesoderm (psm) [2].
  • Moreover, analyses of MRFs, MSP, and IGFs in the knock-down embryos by RT-PCR revealed the up-regulation of MyoD, Myogenin, and Mck transcription, whereas IGF-2 transcription showed mild response with no effect on IGF-1, Desmin, and Myf5 [3].
  • At the end of 10 wk of training, heart and axial muscle showed increased expression of the muscle growth factor myogenin and proliferating cell nuclear antigen, but there were major differences between cardiac and axial muscle [4].
  • The genes encoding Myf-5 and MyoD were switched on first in the unsegmented mesoderm, followed by myogenin as the somites developed [5].

Biological context of myog


Anatomical context of myog


  1. Characterization of a muscle-specific enhancer in human MuSK promoter reveals the essential role of myogenin in controlling activity-dependent gene regulation. Tang, H., Veldman, M.B., Goldman, D. J. Biol. Chem. (2006) [Pubmed]
  2. Retinoic acid activates myogenesis in vivo through Fgf8 signalling. Hamade, A., Deries, M., Begemann, G., Bally-Cuif, L., Genêt, C., Sabatier, F., Bonnieu, A., Cousin, X. Dev. Biol. (2006) [Pubmed]
  3. Up-regulation of muscle-specific transcription factors during embryonic somitogenesis of zebrafish (Danio rerio) by knock-down of myostatin-1. Amali, A.A., Lin, C.J., Chen, Y.H., Wang, W.L., Gong, H.Y., Lee, C.Y., Ko, Y.L., Lu, J.K., Her, G.M., Chen, T.T., Wu, J.L. Dev. Dyn. (2004) [Pubmed]
  4. Endurance exercise differentially stimulates heart and axial muscle development in zebrafish (Danio rerio). van der Meulen, T., Schipper, H., van den Boogaart, J.G., Huising, M.O., Kranenbarg, S., van Leeuwen, J.L. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2006) [Pubmed]
  5. Temperature and the expression of myogenic regulatory factors (MRFs) and myosin heavy chain isoforms during embryogenesis in the common carp Cyprinus carpio L. Cole, N.J., Hall, T.E., Martin, C.I., Chapman, M.A., Kobiyama, A., Nihei, Y., Watabe, S., Johnston, I.A. J. Exp. Biol. (2004) [Pubmed]
  6. Muscle-specific expression of myogenin in zebrafish embryos is controlled by multiple regulatory elements in the promoter. Du, S.J., Gao, J., Anyangwe, V. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2003) [Pubmed]
  7. Characterization of muscle-regulatory genes, Myf5 and myogenin, from striped bass and promoter analysis of muscle-specific expression. Tan, X., Hoang, L., Du, S. Mar. Biotechnol. (2002) [Pubmed]
  8. Muscle regulatory factor gene: zebrafish (Danio rerio) myogenin cDNA. Chen, Y.H., Lee, W.C., Cheng, C.H., Tsai, H.J. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2000) [Pubmed]
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