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Gene Review:

RT1-A3 - RT1 class I, locus A3

Rattus norvegicus

Synonyms: RT1-A, RT1.A3

Spencer, S.C. et al., Powis, S.J. et al., González-Muñoz, A.L. et al., Hart, D.N. et al., Inomata, T. et al., et al.

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High impact information on RT1-A3

The dominant trans-acting major histocompatibility complex (MHC)-linked class I modifier (cim) locus, previously recognized through its ability to determine altered alloantigenicity of a rat class I molecule, RT1.A3, is shown here to influence class I intracellular transport [1].
RT1-A1(o/d) and -A2(o/d) are closely related in sequence to other cloned rat class Ia genes that have been shown to map to the RT1-A region, while RT1-A3 degrees is highly homologous to a class I gene identified by sequencing an RT1-A(n) genomic contig and is named A3(n) [2].
The water-soluble RT1-A molecule had a discrete heavy chain of 40 kD, linked noncovalently to beta 2 microglobulin [3].
The heavy chain of the water-soluble RT1-A molecule was 5 kD smaller than the membrane-bound form of RT1-A from DA liver membranes [3].
Using a combination of monoclonal antibody affinity, lentil lectin affinity, and gel permeation chromatography, we were able to obtain large quantities of pure water-soluble RT1-A antigens [3].

Biological context of RT1-A3

Large quantities of this water-soluble RT1-A class I antigen from the DA strain, given intravenously to PVG recipients of DA cardiac allografts by a variety of protocols, did not have any effect on graft survival [3].

Anatomical context of RT1-A3

The class I (RT1A) antigens were found to be expressed by pancreatic islet cells, adrenal cortical cells, thyroid follicular cells, and--in low concentration--on cells of the adrenal medulla [4].

Other interactions of RT1-A3

The LEJ(RT1-AuBb) inbred rat strain showed a low response to BI, indicating that Ir-BI is closer to RT1-B/RT1-D region than to RT1-A [5].

Analytical, diagnostic and therapeutic context of RT1-A3

Bulk purification of a naturally occurring soluble form of RT1-A class I major histocompatibility complex antigens from DA rat liver, and studies of specific immunosuppression [3].
Renal transplantation of RT1-B-matched, RT1-A-mismatched rats [6].

References

The major histocompatibility complex class II-linked cim locus controls the kinetics of intracellular transport of a classical class I molecule. Powis, S.J., Howard, J.C., Butcher, G.W. J. Exp. Med. (1991) [Pubmed]
A novel instance of class I modification (cim) affecting two of three rat class I RT1-A molecules within one MHC haplotype. González-Muñoz, A.L., Le Rolle, A.F., Brun, H., Hedrich, H.J., Wedekind, D., Powis, S.J., Joly, E., Butcher, G.W. J. Immunol. (2003) [Pubmed]
Bulk purification of a naturally occurring soluble form of RT1-A class I major histocompatibility complex antigens from DA rat liver, and studies of specific immunosuppression. Spencer, S.C., Fabre, J.W. Transplantation (1987) [Pubmed]
Major histocompatibility complex antigens in the rat pancreas, isolated pancreatic islets, thyroid, and adrenal. Hart, D.N., Newton, M.R., Reece-Smith, H., Fabre, J.W., Morris, P.J. Transplantation (1983) [Pubmed]
RT1-linked Ir and Is genes control the immune response to bovine insulin in the rat. Inomata, T., Natori, T., Fujimoto, Y., Tsutimoto, S., Oikawa, K., Aizawa, M. Immunogenetics (1983) [Pubmed]
Renal transplantation of RT1-B-matched, RT1-A-mismatched rats. Norman, D.J., Carpenter, C.B., Paradysz, J.M. Transplant. Proc. (1979) [Pubmed]

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