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Gene Review

RT1-B  -  RT1 class II, locus B

Rattus norvegicus

Synonyms: RT1 class II histocompatibility antigen, A beta chain, Rano class II histocompatibility antigen, A beta chain
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Disease relevance of RT1-B


High impact information on RT1-B

  • Immunological properties of subcellular rat lymphocyte preparations. Primary allogeneic stimulation in vitro by fractions containing Ia (RT1-B), but not RT1-A antigens [3].
  • Inhibition of lesion development was accompanied by expression of the class II histocompatibility (Ia) gene, RT1B, suggesting that both were directly related to the administration of gIFN [4].
  • The encephalitogenic rat T cell clone C14 recognizes the myelin basic protein 69-89 peptide in the context of the RT1B major histocompatibility complex (MHC) class II molecule [5].
  • Following DA skin grafting, there was an accelerated production of antibodies to whole, undenatured class I MHC molecules, even in the LEW rats preimmunized with RT1-B alpha and RT1-B beta chains [6].
  • The uveitogenic lymphocyte line (ThS) stains positively for the ART 18 (IL-2 receptor) and W3/25 (T helper/inducer); negatively for OX6 (RT1B) and OX8 (T suppressor/cytotoxic cells) [7].

Biological context of RT1-B


Anatomical context of RT1-B

  • Finally, expression of RT1-B (Ia) but not ED-2 is reported to be typical of interstitial dendritic cells rather than tissue macrophages, suggesting a unique function for the glomerular and periglomerular macrophage infiltrate in this model [11].
  • The RT1-B/D region-associated antigens which were serologically defined in the previous study (Ohhashi et al., 1981), were partially purified from membranes of a rat B cell leukaemia, KNL-14 [12].
  • An immunohistochemical procedure was carried out on alternate, serial, cryostat sections with antibodies against CDllb (macrophages, dendritic cells) and class II major histocompatibility complex (MHC) molecules (RT1B) [13].
  • RESULTS: Before the induction of EC, cells stained with OX6 (rat MHC class 2, RT1B), ED1 (tissue macrophages), ED2 (resident macrophages), CD4, or major basic protein were present in the peripheral corneal stroma [14].

Associations of RT1-B with chemical compounds


Other interactions of RT1-B

  • Here we describe the complementary DNA (cDNA) sequence encoding the alpha and beta chains of both the RT1-B and RT1-D locus genes of the rat RT1u haplotype [16].
  • Hence, it is possible to generate Ia-related allogeneic helper signals in primary, as well as secondary, in vitro responses, using subcellular membrane fragments that have restricted expression of RT1-B-, but not RT1-A-, encoded antigens [3].
  • The rat major histocompatibility complex loci RT1-B and RT1-D are equivalent to the human leucocyte antigens HLA-DQ and HLA-DR respectively [16].
  • The LEJ(RT1-AuBb) inbred rat strain showed a low response to BI, indicating that Ir-BI is closer to RT1-B/RT1-D region than to RT1-A [17].

Analytical, diagnostic and therapeutic context of RT1-B

  • Rat thymocyte membrane fractions have been prepared which exhibit strain-specific primary mixed-lymphocyte reaction (MLR)-stimulating and Ia (RT1-B) antigenic properties [3].
  • In intra-MHC recombinant rat strains the element determining rejection or acceptance of the allograft mapped to the RT1-B/D-C/E/M region in PVG.R8 and PVG.R23 rats, in accordance with the patterns of NK alloreactivity in these strain combinations [18].
  • Renal transplantation of RT1-B-matched, RT1-A-mismatched rats [19].
  • Ultrastructural analysis, along with immunocytochemistry for RT1B (indicating the presence of MHCII) and using antibody against mononuclear phagocytes, showed the cells to be macrophages [20].
  • METHODS: Age-matched Buffalo (RT1B) rats randomly assigned to 7 experimental groups received either a Lewis (RT1L) rat posterior tibial-sciatic nerve allograft or a Buffalo (RT1B) syngeneic isograft [21].


  1. Suppression of experimental membranous glomerulonephritis in rats by an anti-MHC class II antibody. Hasegawa, Y., Kaneoka, H., Tanaka, T., Ogahara, S., Matsumae, T., Noda, R., Yoshitake, K., Murata, T., Naito, S. Nephron (2001) [Pubmed]
  2. Spontaneous lymphocytic infiltrates of oral mucosa in HgCl2 induced autoimmunity of BN rats: phenotypic characteristics and contact hypersensitivity to Hg. Warfvinge, G., Larsson, A. Regional immunology. (1990) [Pubmed]
  3. Immunological properties of subcellular rat lymphocyte preparations. Primary allogeneic stimulation in vitro by fractions containing Ia (RT1-B), but not RT1-A antigens. Kaldany, A., Carpenter, C.B., Shadur, C.A., George, K., Lundin, A.P., Suthanthiran, M., Strom, T.B. J. Exp. Med. (1980) [Pubmed]
  4. Interferon-gamma inhibits arterial stenosis after injury. Hansson, G.K., Holm, J. Circulation (1991) [Pubmed]
  5. Production, characterization, and immunogenicity of a soluble rat single chain T cell receptor specific for an encephalitogenic peptide. McMahan, R.H., Watson, L., Meza-Romero, R., Burrows, G.G., Bourdette, D.N., Buenafe, A.C. J. Biol. Chem. (2003) [Pubmed]
  6. Allorecognition of isolated, denatured chains of class I and class II major histocompatibility complex molecules. Evidence for an important role for indirect allorecognition in transplantation. Dalchau, R., Fangmann, J., Fabre, J.W. Eur. J. Immunol. (1992) [Pubmed]
  7. Dynamics of experimental autoimmune uveoretinitis induced by adoptive transfer of S-antigen-specific T cell line. Chan, C.C., Caspi, R.R., Roberge, F.G., Nussenblatt, R.B. Invest. Ophthalmol. Vis. Sci. (1988) [Pubmed]
  8. Open reading frame sequencing and structure-based alignment of polypeptides encoded by RT1-Bb, RT1-Ba, RT1-Db, and RT1-Da alleles. Ettinger, R.A., Moustakas, A.K., Lobaton, S.D. Immunogenetics (2004) [Pubmed]
  9. Role of micro-chimerism in inducing immunological tolerance by intraportal injection of donor spleen cells in rats. Nagano, H., Tanigawa, T., Yoshida, T., Ota, H., Akagi, K., Hasuike, Y., Gotoh, M., Nishisho, I., Monden, M. Cell transplantation. (1995) [Pubmed]
  10. RT1B/D+ non-lymphoid DC in early GVHD and Hg-induced autoimmunity of rat salivary and lacrimal glands. Larsson, A., Fujiwara, K., Peszkowski, M. Adv. Exp. Med. Biol. (1993) [Pubmed]
  11. Phenotypic analysis of the glomerular and periglomerular mononuclear cell infiltrates in the Thy 1.1 model of glomerulonephritis. Roy-Chaudhury, P., Wu, B., McDonald, S., Haites, N.E., Simpson, J.G., Power, D.A. Lab. Invest. (1995) [Pubmed]
  12. Immunochemical evidence for multiple beta units of the class II molecule in the rat. Natori, T., Ohhashi, T., Inomata, T., Fujimoto, Y., Ishida, Y., Kasahara, M., Aizawa, M. J. Immunogenet. (1983) [Pubmed]
  13. Delayed recruitment of immunocompetent cells in denervated rat periodontal ligament following experimental tooth movement. Vandevska-Radunovic, V., Kvinnsland, S., Jonsson, R. J. Dent. Res. (1999) [Pubmed]
  14. Phenotypic changes and inflammatory cell distribution in the cornea during development of experimental immune-mediated blepharoconjunctivitis. Ozaki, A., Ishida, W., Fukata, K., Fukushima, A., Ueno, H. Jpn. J. Ophthalmol. (2004) [Pubmed]
  15. Alloantibody and transferable suppressor activity induced by cyclosporine and blood transfusions in the rat. Jones, M.C., Power, D.A., Cunningham, C., Stewart, K.N., Catto, G.R. Transplantation (1988) [Pubmed]
  16. Complementary DNA sequences encoding the rat MHC class II RT1-Bu and RT1-Du alpha and beta chains. Easterfield, A.J., Bradley, J.A., Bolton, E.M. Immunogenetics (2003) [Pubmed]
  17. RT1-linked Ir and Is genes control the immune response to bovine insulin in the rat. Inomata, T., Natori, T., Fujimoto, Y., Tsutimoto, S., Oikawa, K., Aizawa, M. Immunogenetics (1983) [Pubmed]
  18. Long-term donor chimerism after MHC (RT1) mismatched bone marrow transplantation in the rat: the role of host alloreactive NK cells. Engh, E., Strøm-Gundersen, I., Benestad, H.B., Rolstad, B. Scand. J. Immunol. (2001) [Pubmed]
  19. Renal transplantation of RT1-B-matched, RT1-A-mismatched rats. Norman, D.J., Carpenter, C.B., Paradysz, J.M. Transplant. Proc. (1979) [Pubmed]
  20. Adipose tissue in Walker 256 tumour-induced cachexia: possible association between decreased leptin concentration and mononuclear cell infiltration. Machado, A.P., Costa Rosa, L.F., Seelaender, M.C. Cell Tissue Res. (2004) [Pubmed]
  21. Induction of donor-specific tolerance to rat nerve allografts with portal venous donor alloantigen and anti-ICAM-1/LFA-1 monoclonal antibodies. Genden, E.M., Mackinnon, S.E., Yu, S., Flye, M.W. Surgery (1998) [Pubmed]
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