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Gene Review

Ogg1  -  CG1795 gene product from transcript CG1795-RA

Drosophila melanogaster

Synonyms: 1795, BcDNA:LD19945, CG1795, Dmel\CG1795, N-glycosylase/DNA lyase, ...
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Disease relevance of Ogg1

  • Cleavage of 8-OH-Gua.C duplex involves the formation of a reaction intermediate that is converted into a stable covalent adduct in the presence of sodium borohydre. dOgg1 complements the mutator phenotype of fpg mutY mutants of Escherichia coli [1].

High impact information on Ogg1


Biological context of Ogg1

  • Here we describe a second Drosophila protein (dOgg1) with 8-OH-Gua and abasic (AP) site DNA repair activities [1].
  • Another notable finding was that ectopic expression of either dOgg1 or RpS3 in mitochondria increased cell survival after exposure to the nitric oxide donor SNAP [2].
  • Even in the absence of oxidative challenge, cells expressing RpS3 or dOgg1 in mitochondria exhibited increased apoptosis relative to controls, as determined by flow-cytometric analysis of Annexin V and DNA degradation measured by the Comet assay [2].

Associations of Ogg1 with chemical compounds

  • Enzymatic assays using oligodeoxyribonucleotides containing a single lesion show that dOgg1 displays a marked preference for DNA duplexes containing 8-OH-Gua, 8-OH-Ade or an AP site placed opposite a cytosine [1].

Other interactions of Ogg1

  • Drosophila DNA glycosylases, dOgg1 and RpS3, were ectopically expressed within the mitochondrial matrix in Drosophila S2 cells, causing a severalfold decrease in the levels of 8-oxodG in mitochondrial DNA [2].

Analytical, diagnostic and therapeutic context of Ogg1

  • Whole-mount in situ hybridizations on tissues at different stages of Drosophila development reveal that the dOGG1 messenger is expressed uniformly at a low level in cells in which mitotic division occurs [1].
  • The DNA glycosylase activity of purified dOgg1 was investigated using gamma-irradiated DNA and gas chromatography/isotope dilution mass spectrometry (GC/IDMS) [1].


  1. Repair of oxidative DNA damage in Drosophila melanogaster: identification and characterization of dOgg1, a second DNA glycosylase activity for 8-hydroxyguanine and formamidopyrimidines. Dherin, C., Dizdaroglu, M., Doerflinger, H., Boiteux, S., Radicella, J.P. Nucleic Acids Res. (2000) [Pubmed]
  2. Effects of ectopic expression of Drosophila DNA glycosylases dOgg1 and RpS3 in mitochondria. Radyuk, S.N., Michalak, K., Rebrin, I., Sohal, R.S., Orr, W.C. Free Radic. Biol. Med. (2006) [Pubmed]
  3. Arabidopsis thaliana Ogg1 protein excises 8-hydroxyguanine and 2,6-diamino-4-hydroxy-5-formamidopyrimidine from oxidatively damaged DNA containing multiple lesions. Morales-Ruiz, T., Birincioglu, M., Jaruga, P., Rodriguez, H., Roldan-Arjona, T., Dizdaroglu, M. Biochemistry (2003) [Pubmed]
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