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Gene Review

Ogg1  -  8-oxoguanine DNA glycosylase

Rattus norvegicus

Synonyms: Mmh, N-glycosylase/DNA lyase, Ogh1
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Disease relevance of Ogg1


High impact information on Ogg1


Biological context of Ogg1


Anatomical context of Ogg1


Associations of Ogg1 with chemical compounds


Other interactions of Ogg1


Analytical, diagnostic and therapeutic context of Ogg1


  1. Acetoaminophen-induced accumulation of 8-oxodeoxyguanosine through reduction of Ogg1 DNA repair enzyme in C6 glioma cells. Wan, J., Bae, M.A., Song, B.J. Exp. Mol. Med. (2004) [Pubmed]
  2. Rat 7,8-dihydro-8-oxoguanine DNA glycosylase: substrate specificity, kinetics and cleavagemechanism at an apurinic site. Prieto Alamo, M.J., Jurado, J., Francastel, E., Laval, F. Nucleic Acids Res. (1998) [Pubmed]
  3. No evidence of mitochondrial respiratory dysfunction in OGG1-null mice deficient in removal of 8-oxodeoxyguanine from mitochondrial DNA. Stuart, J.A., Bourque, B.M., de Souza-Pinto, N.C., Bohr, V.A. Free Radic. Biol. Med. (2005) [Pubmed]
  4. Effects of melanin and manganese on DNA damage and repair in PC12-derived neurons. Sava, V., Mosquera, D., Song, S., Cardozo-Pelaez, F., Sánchez-Ramos, J.R. Free Radic. Biol. Med. (2004) [Pubmed]
  5. Reduced constitutive 8-oxoguanine-DNA glycosylase expression and impaired induction following oxidative DNA damage in the tuberin deficient Eker rat. Habib, S.L., Phan, M.N., Patel, S.K., Li, D., Monks, T.J., Lau, S.S. Carcinogenesis (2003) [Pubmed]
  6. Formation of 8-hydroxydeoxyguanosine and cell-cycle arrest in the rat liver via generation of oxidative stress by phenobarbital: association with expression profiles of p21(WAF1/Cip1), cyclin D1 and Ogg1. Kinoshita, A., Wanibuchi, H., Imaoka, S., Ogawa, M., Masuda, C., Morimura, K., Funae, Y., Fukushima, S. Carcinogenesis (2002) [Pubmed]
  7. Enhanced mtDNA repair capacity protects pulmonary artery endothelial cells from oxidant-mediated death. Dobson, A.W., Grishko, V., LeDoux, S.P., Kelley, M.R., Wilson, G.L., Gillespie, M.N. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]
  8. 8-oxoguanine DNA glycosylase, but not Kin17 protein, is translocated and differentially regulated by estrogens in rat brain cells. Araneda, S., Pelloux, S., Radicella, J.P., Angulo, J., Kitahama, K., Gysling, K., Forray, M.I. Neuroscience (2005) [Pubmed]
  9. Expression of Kin17 and 8-OxoG DNA glycosylase in cells of rodent and quail central nervous system. Araneda, S., Mermet, N., Verjat, T., Angulo, J.F., Radicella, J.P. Brain Res. Bull. (2001) [Pubmed]
  10. In vivo inosine protects alveolar epithelial type 2 cells against hyperoxia-induced DNA damage through MAP kinase signaling. Buckley, S., Barsky, L., Weinberg, K., Warburton, D. Am. J. Physiol. Lung Cell Mol. Physiol. (2005) [Pubmed]
  11. Asbestos induces mitochondrial DNA damage and dysfunction linked to the development of apoptosis. Shukla, A., Jung, M., Stern, M., Fukagawa, N.K., Taatjes, D.J., Sawyer, D., Van Houten, B., Mossman, B.T. Am. J. Physiol. Lung Cell Mol. Physiol. (2003) [Pubmed]
  12. Detection of 8-oxoG DNA glycosylase activity and OGG1 transcripts in the rat CNS. Verjat, T., Dhénaut, A., Radicella, J.P., Araneda, S. Mutat. Res. (2000) [Pubmed]
  13. Ethanol modulates rat hepatic DNA repair functions. Navasumrit, P., Margison, G.P., O'Connor, P.J. Alcohol Alcohol. (2001) [Pubmed]
  14. Cadmium exposure down-regulates 8-oxoguanine DNA glycosylase expression in rat lung and alveolar epithelial cells. Potts, R.J., Watkin, R.D., Hart, B.A. Toxicology (2003) [Pubmed]
  15. Accumulation of 8-oxoguanine in the cellular DNA and the alteration of the OGG1 expression during ischemia-reperfusion injury in the rat kidney. Tsuruya, K., Furuichi, M., Tominaga, Y., Shinozaki, M., Tokumoto, M., Yoshimitsu, T., Fukuda, K., Kanai, H., Hirakata, H., Iida, M., Nakabeppu, Y. DNA Repair (Amst.) (2003) [Pubmed]
  16. Dietary elevated sucrose modulation of diesel-induced genotoxicity in the colon and liver of Big Blue rats. Risom, L., Møller, P., Hansen, M., Autrup, H., Bornholdt, J., Vogel, U., Wallin, H., Poulsen, H.E., Dragsted, L.O., Loft, S. Arch. Toxicol. (2003) [Pubmed]
  17. Linkage mapping of the rat 8-oxoguanine DNA glycosylase gene to chromosome 4. Masuda, K., Miyamoto, T., Jung, C.G., Ding, M., Cheng, J.M., Tsumagari, T., Manabe, T., Agui, T. Exp. Anim. (2001) [Pubmed]
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