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Gene Review

OGG1  -  8-oxoguanine glycosylase OGG1

Saccharomyces cerevisiae S288c

Synonyms: N-glycosylase/DNA lyase, YM9958.02, YML060W
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Disease relevance of OGG1

  • No significant acceleration was observed in the repair of either a single AP site cleaved by the bifunctional glycosylase NTH of E. coli or the repair of a single 8-oxoguanine, initiated by the bifunctional glycosylase OGG1 [1].

High impact information on OGG1

  • In S. cerevisiae, mutations in MSH2 or MSH6 caused a synergistic increase in mutation rate in combination with mutations in OGG1, which encodes a MutM homolog, resulting in a 140- to 218-fold increase in the G:C-to-T:A transversion rate [2].
  • Eukaryotic cells use a specific DNA glycosylase, the product of the OGG1 gene, to excise 8-oxoG from DNA [3].
  • DNA sequencing identified an open reading frame, designated OGG1, which encodes a protein of 376 amino acids with a molecular mass of 43 kDa [4].
  • The OGG1 gene was inserted in plasmid pUC19, yielding pYSB110 [4].
  • A search of the yeast genome database using peptide sequences from the protein identified a gene, OGG1, encoding a predicted 43 kDa (376 amino acid) protein, identical to one identified independently by complementation cloning [5].

Biological context of OGG1


Associations of OGG1 with chemical compounds

  • Excision of 8-oxoguanine within clustered damage by the yeast OGG1 protein [11].
  • The ability of yeast OGG1 to excise 8-oxoG was determined when another type of damage [dihydrothymine, uracil, 8-oxoG, abasic (AP) site or various types of single-strand breaks (SSBs)] is present on the complementary strand 1, 3 or 5 bases 5' or 3' opposite to 8-oxoG [11].

Other interactions of OGG1

  • The roles of OGG1 and NTG2 genes in the repair of lethal and mutagenic oxidative lesions induced by H2O2 and their relationships with iron and copper ions are discussed [6].

Analytical, diagnostic and therapeutic context of OGG1


  1. Effect of S. cerevisiae APN1 protein on mammalian DNA base excision repair. Bogliolo, M., Cappelli, E., D'Osualdo, A., Rossi, O., Barbieri, O., Kelley, M.R., Frosina, G. Anticancer Res. (2003) [Pubmed]
  2. MSH2 and MSH6 are required for removal of adenine misincorporated opposite 8-oxo-guanine in S. cerevisiae. Ni, T.T., Marsischky, G.T., Kolodner, R.D. Mol. Cell (1999) [Pubmed]
  3. Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage. Klungland, A., Rosewell, I., Hollenbach, S., Larsen, E., Daly, G., Epe, B., Seeberg, E., Lindahl, T., Barnes, D.E. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  4. Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine. van der Kemp, P.A., Thomas, D., Barbey, R., de Oliveira, R., Boiteux, S. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  5. Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily. Nash, H.M., Bruner, S.D., Schärer, O.D., Kawate, T., Addona, T.A., Spooner, E., Lane, W.S., Verdine, G.L. Curr. Biol. (1996) [Pubmed]
  6. Role of OGG1 and NTG2 in the repair of oxidative DNA damage and mutagenesis induced by hydrogen peroxide in Saccharomyces cerevisiae: relationships with transition metals iron and copper. Melo, R.G., Leitão, A.C., Pádula, M. Yeast (2004) [Pubmed]
  7. DNA repair: how yeast repairs radical damage. Cunningham, R.P. Curr. Biol. (1996) [Pubmed]
  8. Expression of the Fpg protein of Escherichia coli in Saccharomyces cerevisiae: effects on spontaneous mutagenesis and sensitivity to oxidative DNA damage. Guibourt, N., Boiteux, S. Biochimie (2000) [Pubmed]
  9. Excision repair of 8-hydroxyguanine in mammalian cells: the mouse Ogg1 protein as a model. Boiteux, S., Dhérin, C., Reille, F., Apiou, F., Dutrillaux, B., Radicella, J.P. Free Radic. Res. (1998) [Pubmed]
  10. Inactivation of OGG1 increases the incidence of G . C-->T . A transversions in Saccharomyces cerevisiae: evidence for endogenous oxidative damage to DNA in eukaryotic cells. Thomas, D., Scot, A.D., Barbey, R., Padula, M., Boiteux, S. Mol. Gen. Genet. (1997) [Pubmed]
  11. Excision of 8-oxoguanine within clustered damage by the yeast OGG1 protein. David-Cordonnier, M.H., Boiteux, S., O'Neill, P. Nucleic Acids Res. (2001) [Pubmed]
  12. The Ogg1 protein of Saccharomyces cerevisiae: a 7,8-dihydro-8-oxoguanine DNA glycosylase/AP lyase whose lysine 241 is a critical residue for catalytic activity. Girard, P.M., Guibourt, N., Boiteux, S. Nucleic Acids Res. (1997) [Pubmed]
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