Disease relevance of dp

• These data lend support to the thesis that (1) complete dumpy mutations of the olv and ov types are more frequently associated with chromosomal aberrations than those of the ol, lv, o, v and c types, and (2) fractional mutations and complete mutations of the (ol, lv, o, v, c) types are most probably point mutational events [1].

High impact information on dp

• Here we report that two proteins, Piopio (Pio) and Dumpy (Dp), containing a zona pellucida (ZP) domain are essential for the generation of the interconnected tracheal network in Drosophila melanogaster [2].
• These range from embryonic lethality (B1) and embryonic/larval lethality (A3) to larval lethality (A1 and A2) and a mild dumpy phenotype of adults (C2) [3].
• Disruption of CHR3 (nhr-23) function leads to developmental changes, including incomplete molting and a short, fat (dumpy) phenotype [4].
• Consistent with its cuticle phenotypes, dumpy is expressed at several sites of cuticle-epidermal cell attachment, including the trachea and the muscle tendon cells, which mediate anchorage of the muscles to the cuticle [5].
• RESULTS: The genetically complex dumpy locus was found to span over 100 kb and encode a gigantic 2.5 MDa extracellular matrix protein [5].

Biological context of dp

• Among recombinants, al dp was the most and b pr the next most frequent phenotype in the progenies of F1, TC1, TC2 and TC3 males of genotype + /al dp br [6].
• The dumpy gene of the fruit fly Drosophila melanogaster is an example of the latter class, with mutant phenotypes affecting size and shape of the limbs, thoracic cuticle, trachea and mouthparts [5].
• The gamma-ray (60Co) induction of the dumpy and Minute mutations, and the hyperploid exceptions during spermatogenesis was investigated by using a recombination-defective strain of Drosophila melanogaster, c3G and its wild-type strain, Oregon-R (c3G+) [7].

Anatomical context of dp

• Loss of Piopio, but not Papillote or Dumpy, causes the absence of specialized microtubule bundles from pupal wings, suggesting that Piopio plays a role in microtubule organization [8].
• Our results indicate that in dumpy and taxi mutants, there are no detectable modifications in the neural projections or in the number and morphology of sensory receptors [9].
• Induction of dumpy mutations in female germ cells of Drosophila melanogaster by ethyl methanesulphonate [10].

Associations of dp with chemical compounds

• The significance of the observations is discussed in relation to the role of pyrimidine biosynthesis in dp expressivity and chitin synthesis [11].
• However, neither the low nucleotide diet nor uracil supplementation results in a change in the expressivity of the dp mutant phenotypes [11].

Other interactions of dp

• Mutations in four known genes (blistered, Delta, dumpy and mastermind) were isolated [12].
• The results show that: (1) no essential difference exists in the response patterns for the dumpy and Minute mutations between these two strains; (2) however, a striking difference exists in the response pattern for the hyperploid exceptions [7].

References