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Gene Review:

KIF2A - kinesin heavy chain member 2A

Homo sapiens

Synonyms: CDCBM3, HK2, KIF2, KNS2, Kinesin-2, ...

Brown, C.L. et al., Haraguchi, K. et al., Debernardi, S. et al., Dietz, A.B. et al., Kural, C. et al., et al.

Dietz, Bulur, Knutson, Matasić, Vuk-Pavlović, Hirokawa, Takemura,

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Disease relevance of KIF2A

We identified maturation-dependent changes in the levels of transcripts for numerous genes encoding proteins previously undetected in dendritic cells such as indoleamine 2,3-deoxygenase, Epstein-Barr virus induced protein 3 and kinesin-2 [1].

High impact information on KIF2A

Melanosome transport in cultured Xenopus melanophores is mediated by myosin V, heterotrimeric kinesin-2, and cytoplasmic dynein [2].
Role of the kinesin-2 family protein, KIF3, during mitosis [3].
Our data suggested that the kinesin-2 complex plays an important role not only in interphase but also in mitosis [3].
We have shown here that the kinesin-2 complex is localized with components of the mitotic apparatus such as spindle microtubules and centrosomes [3].
In the present study, we have analyzed this region in the human renal proximal tubular epithelial cell line HK-2 [4].

Biological context of KIF2A

A shorter form of the HK2 mRNA (HK2s), containing a 57-nt deletion in the open reading frame, has also been detected [5].
By the use of radiation hybrids, HK2 has been localized to chromosome 5q12-q13 [5].
Here we report that 5 ng/ml EGF led to a strong stimulation of HK-2 cell proliferation, which was largely U0126-sensitive [6].

Anatomical context of KIF2A

Northern analysis revealed that HK2 is widely expressed among hemopoietic and nonhemopoietic cell lines and tissues [5].
Kinesin-2 is a motor for late endosomes and lysosomes [7].
The slow time-course of inhibition suggests that both kinesin-2 itself and its attachment to membranes do not turn over quickly [7].
Kinesin-2 is known to drive the movement of pigment granules, a type of lysosomally derived organelle, and was recently found to be associated with purified late endosomes [7].
A Role for Kinesin-2 in COPI-Dependent Recycling between the ER and the Golgi Complex [8].

Analytical, diagnostic and therapeutic context of KIF2A

X-ray crystallography has revealed the structural uniqueness of KIF2 underlying the microtubule-depolymerizing activity [9].

References

Maturation of human monocyte-derived dendritic cells studied by microarray hybridization. Dietz, A.B., Bulur, P.A., Knutson, G.J., Matasić, R., Vuk-Pavlović, S. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
Tracking melanosomes inside a cell to study molecular motors and their interaction. Kural, C., Serpinskaya, A.S., Chou, Y.H., Goldman, R.D., Gelfand, V.I., Selvin, P.R. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
Role of the kinesin-2 family protein, KIF3, during mitosis. Haraguchi, K., Hayashi, T., Jimbo, T., Yamamoto, T., Akiyama, T. J. Biol. Chem. (2006) [Pubmed]
Sp1 and Sp3 mediate constitutive transcription of the human hyaluronan synthase 2 gene. Monslow, J., Williams, J.D., Fraser, D.J., Michael, D.R., Foka, P., Kift-Morgan, A.P., Luo, D.D., Fielding, C.A., Craig, K.J., Topley, N., Jones, S.A., Ramji, D.P., Bowen, T. J. Biol. Chem. (2006) [Pubmed]
Identification of a novel human kinesin-related gene (HK2) by the cDNA differential display technique. Debernardi, S., Fontanella, E., De Gregorio, L., Pierotti, M.A., Delia, D. Genomics (1997) [Pubmed]
ERK1/2-driven and MKP-mediated inhibition of EGF-induced ERK5 signaling in human proximal tubular cells. Sarközi, R., Miller, B., Pollack, V., Feifel, E., Mayer, G., Sorokin, A., Schramek, H. J. Cell. Physiol. (2007) [Pubmed]
Kinesin-2 is a motor for late endosomes and lysosomes. Brown, C.L., Maier, K.C., Stauber, T., Ginkel, L.M., Wordeman, L., Vernos, I., Schroer, T.A. Traffic (2005) [Pubmed]
A Role for Kinesin-2 in COPI-Dependent Recycling between the ER and the Golgi Complex. Stauber, T., Simpson, J.C., Pepperkok, R., Vernos, I. Curr. Biol. (2006) [Pubmed]
Kinesin superfamily proteins and their various functions and dynamics. Hirokawa, N., Takemura, R. Exp. Cell Res. (2004) [Pubmed]

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AgaP_AGAP000159	Anopheles gambiae str. PEST
KIF2A	Bos taurus
KIF2A	Canis lupus familiaris
zgc:103670	Danio rerio
Klp10A	Drosophila melanogaster
KIF2A	Gallus gallus
KIF2A	Macaca mulatta
Kif2a	Mus musculus
KIF2A	Pan troglodytes
Kif2a	Rattus norvegicus
kif2a	Xenopus (Silurana) tropicalis

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