Disease relevance of crq

• In transfection assays, the mammalian Croquemort paralogue CD36 confers binding and internalization of Gram-positive and, to a lesser extent, Gram-negative bacteria [1].

High impact information on crq

• Genetic evidence showed that crq was essential for efficient phagocytosis of apoptotic corpses but was not required for the engulfment of bacteria [2].
• Croquemort (CRQ) is a CD36-related receptor expressed exclusively on these macrophages [2].
• The expression of CRQ was regulated by the amount of apoptosis [2].
• Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells [3].
• However, apoptotic cell phagocytosis was reduced when the expression of Draper, but not of Croquemort, was inhibited by RNA interference in hormone-treated l(2)mbn cells [4].

Biological context of crq

• A total of 1500 host proteins was identified and quantified, of which over 200 proteins were either up- or down-regulated in response to viral infection, such as the up-regulation of the Drosophila apoptotic croquemort protein, and the down-regulation of proteins that inhibited cell death [5].

Anatomical context of crq

• Antennal SNMPs (sensory neuron membrane proteins) of Lepidoptera define a unique family of invertebrate CD36-like proteins [6].

Associations of crq with chemical compounds

• The level of Croquemort, a candidate phagocytosis receptor of Drosophila hemocytes/macrophages, increased in l(2)mbn cells after treatment with 20-hydroxyecdysone, whereas that of Draper, another candidate phagocytosis receptor, remained unchanged [4].

Regulatory relationships of crq

• Animals deficient for both gcm and gcm2 fail to express the macrophage receptor Croquemort [7].

References