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Gene Review

crq  -  croquemort

Drosophila melanogaster

Synonyms: CD36, CG31655, CG4280, CRQ, Cd36, ...
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Disease relevance of crq


High impact information on crq


Biological context of crq

  • A total of 1500 host proteins was identified and quantified, of which over 200 proteins were either up- or down-regulated in response to viral infection, such as the up-regulation of the Drosophila apoptotic croquemort protein, and the down-regulation of proteins that inhibited cell death [5].

Anatomical context of crq


Associations of crq with chemical compounds


Regulatory relationships of crq


  1. Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain. Stuart, L.M., Deng, J., Silver, J.M., Takahashi, K., Tseng, A.A., Hennessy, E.J., Ezekowitz, R.A., Moore, K.J. J. Cell Biol. (2005) [Pubmed]
  2. Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila. Franc, N.C., Heitzler, P., Ezekowitz, R.A., White, K. Science (1999) [Pubmed]
  3. Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells. Franc, N.C., Dimarcq, J.L., Lagueux, M., Hoffmann, J., Ezekowitz, R.A. Immunity (1996) [Pubmed]
  4. Draper-mediated and phosphatidylserine-independent phagocytosis of apoptotic cells by Drosophila hemocytes/macrophages. Manaka, J., Kuraishi, T., Shiratsuchi, A., Nakai, Y., Higashida, H., Henson, P., Nakanishi, Y. J. Biol. Chem. (2004) [Pubmed]
  5. Mass spectrometry reveals specific and global molecular transformations during viral infection. Go, E.P., Wikoff, W.R., Shen, Z., O'Maille, G., Morita, H., Conrads, T.P., Nordstrom, A., Trauger, S.A., Uritboonthai, W., Lucas, D.A., Chan, K.C., Veenstra, T.D., Lewicki, H., Oldstone, M.B., Schneemann, A., Siuzdak, G. J. Proteome Res. (2006) [Pubmed]
  6. Antennal SNMPs (sensory neuron membrane proteins) of Lepidoptera define a unique family of invertebrate CD36-like proteins. Rogers, M.E., Krieger, J., Vogt, R.G. J. Neurobiol. (2001) [Pubmed]
  7. gcm2 promotes glial cell differentiation and is required with glial cells missing for macrophage development in Drosophila. Alfonso, T.B., Jones, B.W. Dev. Biol. (2002) [Pubmed]
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