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Gene Review

Scarb1  -  scavenger receptor class B, member 1

Rattus norvegicus

Synonyms: Cd36l1, SR-B1, SR-BI, SRB1, Scavenger receptor class B member 1, ...
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Disease relevance of Scarb1


High impact information on Scarb1


Biological context of Scarb1

  • The class-B type-I scavenger receptor (SR-BI) plays a key role in cholesterol homeostasis; it mediates the selective uptake of lipoprotein cholesterol to steroidogenic tissues [7].
  • SR-BI gene expression was high in steroid-producing tissues and in the liver, consistent with a role of this receptor in the uptake of HDL cholesterol [8].
  • The results of these studies demonstrate that the rat HDL receptor SR-BI promoter contains two sterol response elements (pSRE and dSRE) through which SREBP-1a can bind and activate transcription of this gene [9].
  • The rat and human SR-BI genes were mapped to a region previously linked between rat and human chromosomes 12 [8].
  • The chromosomal locations of the rat and human SR-BI homologs suggest that this gene is a new member of a previously reported, conserved synteny group [8].

Anatomical context of Scarb1


Associations of Scarb1 with chemical compounds

  • Differential regulation of steroid hormone biosynthesis in R2C and MA-10 Leydig tumor cells: role of SR-B1-mediated selective cholesteryl ester transport [12].
  • Furthermore the expression of SR-BI mRNA in the ovary is stimulated by LH and cyclic AMP (cAMP) [13].
  • Class B scavenger receptor type I (SR-BI), a candidate for the PS receptor, was detected in Sertoli cells [6].
  • The treatment of theca-interstitial cells with anti-SR-BI antibody blocked more than 90% of HDL plus human chorionic gonadotropin-stimulated androstenedione production, and selective HDL-CE uptake [14].
  • Sterol regulatory element-binding protein-1a binds to cis elements in the promoter of the rat high density lipoprotein receptor SR-BI gene [9].

Other interactions of Scarb1


Analytical, diagnostic and therapeutic context of Scarb1


  1. Down-regulation of intestinal scavenger receptor class B, type I (SR-BI) expression in rodents under conditions of deficient bile delivery to the intestine. Voshol, P.J., Schwarz, M., Rigotti, A., Krieger, M., Groen, A.K., Kuipers, F. Biochem. J. (2001) [Pubmed]
  2. Down-regulation of hepatic high-density lipoprotein receptor, SR-B1, in nephrotic syndrome. Liang, K., Vaziri, N.D. Kidney Int. (1999) [Pubmed]
  3. Hepatic HDL receptor, SR-B1 and Apo A-I expression in chronic renal failure. Vaziri, N.D., Deng, G., Liang, K. Nephrol. Dial. Transplant. (1999) [Pubmed]
  4. Impact of the composition of combustion generated fine particles on epithelial cell toxicity: influences of metals on metabolism. Okeson, C.D., Riley, M.R., Fernandez, A., Wendt, J.O. Chemosphere (2003) [Pubmed]
  5. Regulation of SR-BI protein levels by phosphorylation of its associated protein, PDZK1. Nakamura, T., Shibata, N., Nishimoto-Shibata, T., Feng, D., Ikemoto, M., Motojima, K., Iso-O, N., Tsukamoto, K., Tsujimoto, M., Arai, H. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  6. Role of class B scavenger receptor type I in phagocytosis of apoptotic rat spermatogenic cells by Sertoli cells. Shiratsuchi, A., Kawasaki, Y., Ikemoto, M., Arai, H., Nakanishi, Y. J. Biol. Chem. (1999) [Pubmed]
  7. Expression of SR-BI receptor and StAR protein in rat ocular tissues. Provost, A.C., Péquignot, M.O., Sainton, K.M., Gadin, S., Sallé, S., Marchant, D., Hales, D.B., Abitbol, M. C. R. Biol. (2003) [Pubmed]
  8. Characterization and chromosomal localization of rat scavenger receptor class B type I, a high density lipoprotein receptor with a putative leucine zipper domain and peroxisomal targeting sequence. Johnson, M.S., Svensson, P.A., Helou, K., Billig, H., Levan, G., Carlsson, L.M., Carlsson, B. Endocrinology (1998) [Pubmed]
  9. Sterol regulatory element-binding protein-1a binds to cis elements in the promoter of the rat high density lipoprotein receptor SR-BI gene. Lopez, D., McLean, M.P. Endocrinology (1999) [Pubmed]
  10. Simultaneous induction of an HDL receptor protein (SR-BI) and the selective uptake of HDL-cholesteryl esters in a physiologically relevant steroidogenic cell model. Azhar, S., Nomoto, A., Leers-Sucheta, S., Reaven, E. J. Lipid Res. (1998) [Pubmed]
  11. Identification and expression of scavenger receptor SR-BI in endothelial cells and smooth muscle cells of rat aorta in vitro and in vivo. Yeh, Y.C., Hwang, G.Y., Liu, I.P., Yang, V.C. Atherosclerosis (2002) [Pubmed]
  12. Differential regulation of steroid hormone biosynthesis in R2C and MA-10 Leydig tumor cells: role of SR-B1-mediated selective cholesteryl ester transport. Rao, R.M., Jo, Y., Leers-Sucheta, S., Bose, H.S., Miller, W.L., Azhar, S., Stocco, D.M. Biol. Reprod. (2003) [Pubmed]
  13. The role of cyclic AMP response element binding protein in transactivation of scavenger receptor class B type I promoter in transfected cells and in primary cultures of rat theca-interstitial cells. Towns, R., Menon, K.M. Mol. Cell. Endocrinol. (2005) [Pubmed]
  14. Lipoprotein enhancement of ovarian theca-interstitial cell steroidogenesis: relative contribution of scavenger receptor class B (type I) and adenosine 5'-triphosphate- binding cassette (type A1) transporter in high-density lipoprotein-cholesterol transport and androgen synthesis. Wu, Q., Sucheta, S., Azhar, S., Menon, K.M. Endocrinology (2003) [Pubmed]
  15. Effect of pregnancy and lactation on lipoprotein and cholesterol metabolism in the rat. Smith, J.L., Lear, S.R., Forte, T.M., Ko, W., Massimi, M., Erickson, S.K. J. Lipid Res. (1998) [Pubmed]
  16. A role for scavenger receptor B-I in selective transfer of rhodamine-PE from liposomes to cells. Yan, X., Poelstra, K., Scherphof, G.L., Kamps, J.A. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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