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Gene Review

IGJ  -  immunoglobulin J polypeptide, linker...

Homo sapiens

Synonyms: IGCJ, Immunoglobulin J chain, JCH
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Disease relevance of IGJ


High impact information on IGJ


Chemical compound and disease context of IGJ


Associations of IGJ with chemical compounds

  • METHODS: Cocktails of synthetic deoxyoligonucleotides coding for immunoglobulin J chain and kappa light chain were 3' end labelled enzymatically with digoxigenin using terminal deoxynucleotidyl transferase [9].

Physical interactions of IGJ

  • 1. The NF beta A binding element shares 100% sequence identity with a novel PU.1 binding element recently found in the immunoglobulin J-chain promoter [10].

Other interactions of IGJ


Analytical, diagnostic and therapeutic context of IGJ

  • Image-guided gastrojejunal feeding tube placement patients required gastrostomy at an average age of 23.8 months, with conversion to IGJ an average of 17.2 months later [12].
  • Although image-guided gastrojejunal feeding tube placement (IGJ) is becoming the access of choice in many centers, few studies have compared long-term results with surgical jejunostomy (SJ) [12].


  1. Expression of the recombinant human immunoglobulin J chain in Escherichia coli. Symersky, J., Novak, J., McPherson, D.T., DeLucas, L., Mestecky, J. Mol. Immunol. (2000) [Pubmed]
  2. Systolic hypertension; alpha blockers and prostatism; are beta blockers still indicated; diabetes, obesity, and hypertension -- comments on the JCH contents. Moser, M. Journal of clinical hypertension (Greenwich, Conn.) (2001) [Pubmed]
  3. Ets-related protein PU.1 regulates expression of the immunoglobulin J-chain gene through a novel Ets-binding element. Shin, M.K., Koshland, M.E. Genes Dev. (1993) [Pubmed]
  4. A stage-specific enhancer of immunoglobulin J chain gene is induced by interleukin-2 in a presecretor B cell stage. Kang, C.J., Sheridan, C., Koshland, M.E. Immunity (1998) [Pubmed]
  5. Immunoglobulin J chain gene from the mouse. Matsuuchi, L., Cann, G.M., Koshland, M.E. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  6. Photoaffinity approaches to determining the sequence selectivities of DNA-small molecule interactions: actinomycin D and ethidium. Marsch, G.A., Graves, D.E., Rill, R.L. Nucleic Acids Res. (1995) [Pubmed]
  7. Classical Hodgkin and Reed-Sternberg cells demonstrate a non-clonal immature B lymphoid lineage: evidence from a single cell assay and in situ hybridization. Ohshima, K., Suzumiya, J., Mukai, Y., Tashiro, K., Shibata, T., Tanaka, T., Kato, A., Kikuchi, M. Hematological oncology. (1996) [Pubmed]
  8. Obesity and hypertension in children; caffeine, stress, and elevated blood pressure; resistant hypertension; and is it lowering of blood pressure alone that accounts for reduction in cardiovascular events? Comments on the JCH Contents. Moser, M. Journal of clinical hypertension (Greenwich, Conn.) (2001) [Pubmed]
  9. Simultaneous in situ hybridisation of native mRNA and immunoglobulin detection by conventional immunofluorescence in paraffin wax embedded sections. Harper, S.J., Pringle, J.H., Gillies, A., Allen, A.C., Layward, L., Feehally, J., Lauder, I. J. Clin. Pathol. (1992) [Pubmed]
  10. NF beta A, a factor required for maximal interleukin-1 beta gene expression is identical to the ets family member PU.1. Evidence for structural alteration following LPS activation. Buras, J.A., Reenstra, W.R., Fenton, M.J. Mol. Immunol. (1995) [Pubmed]
  11. Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprinting. Ghafouri, B., Ståhlbom, B., Tagesson, C., Lindahl, M. Proteomics (2002) [Pubmed]
  12. Optimal enteral feeding in children with gastric dysfunction: surgical jejunostomy vs image-guided gastrojejunal tube placement. Raval, M.V., Phillips, J.D. J. Pediatr. Surg. (2006) [Pubmed]
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