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Disease relevance of Jejunostomy

  • This study aimed to compare the absorption and tolerance of 20-g lactose loads as milk and yogurt in 17 patients with short-bowel syndrome with either a terminal jejunostomy (group A, n = 6) or a jejunocolic anastomosis (group B, n = 11) [1].
  • Can percutaneous endoscopic jejunostomy prevent gastroesophageal reflux in patients with preexisting esophagitis [2]?
  • Body weight and lean body mass (as assessed by total body potassium and arm muscle circumference) and plasma prealbumin fell significantly in the control patients but not in those fed by jejunostomy [3].
  • The jejunal meal significantly increased TV fistula absorption, whereas oxethazaine significantly reduced basal absorption when administered via the TV fistula and postprandial absorption when administered via the jejunostomy (p less than 0.05) [4].
  • The proposed etiology includes excessive gas accumulation within the small intestine secondary to 1) inadequate nasogastric suction, 2) post-traumatic intestinal ileus, and 3) disaccharide fermentation; combined with a mucosal defect created by the catheter jejunostomy [5].

High impact information on Jejunostomy


Chemical compound and disease context of Jejunostomy


Biological context of Jejunostomy


Anatomical context of Jejunostomy


Associations of Jejunostomy with chemical compounds

  • A sipped glucose electrolyte solution seems to be the optimal mode of sodium replacement in patients with a high output jejunostomy [8].
  • The decreased absorption may be clinically important, especially when the enteral feeding is coadministered with ciprofloxacin by the oral and jejunostomy tube routes [18].
  • Immunosuppression consisted of FK506 (target level 10-15 ng/ml by enzyme immunoparticle assay) and prednisone administered via the jejunostomy [19].
  • Ten patients with an end jejunostomy and one with a jejuno-rectal anastomosis (jejunal length 30-140 cm) ate a constant chosen diet for 2 control days, and 2 test days when 40 mg omeprazole orally was taken each morning [20].
  • METHODS: A benefit/risk analysis comparing complication rate, avoidance of parenteral nutrition, and discontinuation of jejunostomy feeding was performed in 92 patients [21].

Gene context of Jejunostomy

  • CONCLUSION: Percutaneous endoscopic jejunostomy feeding reduced but did not eliminate gastroesophageal reflux, compared to intragastric feeding in patients with severe gastroesophageal reflux [2].
  • METHODS: Virtually all children from Nova Scotia who had gastrostomy or jejunostomy procedures between the years 1980 and 1998 and who had been diagnosed with CP were identified [22].
  • Prolonged treatment including TPN, drainage, broad spectrum antibiotics, skin and would protection and jejunostomy feeding, were necessary to obtain an eventual successful outcome [23].
  • Absorption of cobalamin (vitamin B12) administered via jejunostomy [24].
  • RESULTS: Messenger RNA for NOS-2 was detected in nearly all patients with NEC except for one infant who underwent proximal diverting jejunostomy alone, and who did not have histological evidence of NEC at that site [25].

Analytical, diagnostic and therapeutic context of Jejunostomy


  1. Tolerance and absorption of lactose from milk and yogurt during short-bowel syndrome in humans. Arrigoni, E., Marteau, P., Briet, F., Pochart, P., Rambaud, J.C., Messing, B. Am. J. Clin. Nutr. (1994) [Pubmed]
  2. Can percutaneous endoscopic jejunostomy prevent gastroesophageal reflux in patients with preexisting esophagitis? Lien, H.C., Chang, C.S., Chen, G.H. Am. J. Gastroenterol. (2000) [Pubmed]
  3. Fine needle catheter jejunostomy--an assessment of a new method of nutritional support after major gastrointestinal surgery. Yeung, C.K., Young, G.A., Hackett, A.F., Hill, G.L. The British journal of surgery. (1979) [Pubmed]
  4. Meal-induced jejunal absorption requires intact neural pathways. Anthone, G.J., Wang, B.H., Zinner, M.J., Orandle, M.S., Yeo, C.J. Am. J. Surg. (1992) [Pubmed]
  5. Massive pneumatosis intestinalis and subcutaneous emphysema: complication of needle catheter jejunostomy. Cogbill, T.H., Wolfson, R.H., Moore, E.E., VanWay, C.W., Jones, T.N., Strain, J.D., Rudikoff, J.C. JPEN. Journal of parenteral and enteral nutrition. (1983) [Pubmed]
  6. Long-acting somatostatin analogue therapy and protein metabolism in patients with jejunostomies. O'Keefe, S.J., Haymond, M.W., Bennet, W.M., Oswald, B., Nelson, D.K., Shorter, R.G. Gastroenterology (1994) [Pubmed]
  7. Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon. Jeppesen, P.B., Hartmann, B., Thulesen, J., Hansen, B.S., Holst, J.J., Poulsen, S.S., Mortensen, P.B. Gut (2000) [Pubmed]
  8. Oral salt supplements to compensate for jejunostomy losses: comparison of sodium chloride capsules, glucose electrolyte solution, and glucose polymer electrolyte solution. Nightingale, J.M., Lennard-Jones, J.E., Walker, E.R., Farthing, M.J. Gut (1992) [Pubmed]
  9. The use of hormonal growth factors in the treatment of patients with short-bowel syndrome. Jeppesen, P.B. Drugs (2006) [Pubmed]
  10. Serum voriconazole levels following administration via percutaneous jejunostomy tube. Martinez, V., Le Guillou, J.L., Lamer, C., Le Jouan, M., Tod, M., Dromer, F. Antimicrob. Agents Chemother. (2003) [Pubmed]
  11. Effects of cimetidine on jejunostomy effluents in patients with severe short-bowel syndrome. Jacobsen, O., Ladefoged, K., Stage, J.G., Jarnum, S. Scand. J. Gastroenterol. (1986) [Pubmed]
  12. Conservative surgical treatment for acute pancreatitis: the Lawson procedure. Hesselink, E.J., Slooff, M.J., Bleichrodt, R.P., Van Schilfgaarde, R. The Netherlands journal of surgery. (1987) [Pubmed]
  13. Ciprofloxacin pharmacokinetics after administration via a jejunostomy tube. Sahai, J., Memish, Z., Conway, B. J. Antimicrob. Chemother. (1991) [Pubmed]
  14. The short-bowel syndrome. Nightingale, J.M. European journal of gastroenterology & hepatology. (1995) [Pubmed]
  15. Intestinal ornithine decarboxylase in short bowel syndrome patients with oral diet. Segovia-Silvestre, T., Pita, A.M., Vilar, L., Venereo, Y., Orta, X., Farriol, M. Clinical nutrition (Edinburgh, Scotland) (2001) [Pubmed]
  16. Early postoperative enteral nutrition improves peripheral protein kinetics in upper gastrointestinal cancer patients undergoing complete resection: a randomized trial. Harrison, L.E., Hochwald, S.N., Heslin, M.J., Berman, R., Burt, M., Brennan, M.F. JPEN. Journal of parenteral and enteral nutrition. (1997) [Pubmed]
  17. The short bowel syndrome: what's new and old? Nightingale, J.M., Lennard-Jones, J.E. Digestive diseases (Basel, Switzerland) (1993) [Pubmed]
  18. Ciprofloxacin absorption is impaired in patients given enteral feedings orally and via gastrostomy and jejunostomy tubes. Healy, D.P., Brodbeck, M.C., Clendening, C.E. Antimicrob. Agents Chemother. (1996) [Pubmed]
  19. Comparison of jejunal and ileal surveillance biopsies in a porcine model of intestinal transplantation. Raofi, V., Fontaine, M.J., Mihalov, M.L., Holman, D.M., Dunn, T.B., Vitello, J.M., Asolati, M., Kumins, N.H., Benedetti, E. Transplantation (1999) [Pubmed]
  20. Effect of omeprazole on intestinal output in the short bowel syndrome. Nightingale, J.M., Walker, E.R., Farthing, M.J., Lennard-Jones, J.E. Aliment. Pharmacol. Ther. (1991) [Pubmed]
  21. Prophylactic jejunostomy: a reappraisal. Zapas, J.L., Karakozis, S., Kirkpatrick, J.R. Surgery (1998) [Pubmed]
  22. Living with cerebral palsy and tube feeding: A population-based follow-up study. Smith, S.W., Camfield, C., Camfield, P. J. Pediatr. (1999) [Pubmed]
  23. Successful treatment of gastric fistula following rhabdomyolysis after vertical banded gastroplasty. Pasnik, K., Krupa, J., Stanowski, E., Grzesiak, J., Najdecki, M. Obesity surgery : the official journal of the American Society for Bariatric Surgery and of the Obesity Surgery Society of Australia and New Zealand. (2005) [Pubmed]
  24. Absorption of cobalamin (vitamin B12) administered via jejunostomy. Sriram, K., Gergans, G.A., Badger, H. Journal of the American College of Nutrition. (1989) [Pubmed]
  25. The role of inflammatory cytokines and nitric oxide in the pathogenesis of necrotizing enterocolitis. Ford, H., Watkins, S., Reblock, K., Rowe, M. J. Pediatr. Surg. (1997) [Pubmed]
  26. Postoperative enteral versus parenteral nutritional support in gastrointestinal surgery. A matched prospective study. Muggia-Sullam, M., Bower, R.H., Murphy, R.F., Joffe, S.N., Fischer, J.E. Am. J. Surg. (1985) [Pubmed]
  27. Sodium homeostasis after small-bowel resection. Ladefoged, K., Olgaard, K. Scand. J. Gastroenterol. (1985) [Pubmed]
  28. Esophageal perforations encountered during the dilation of caustic esophageal strictures. Karnak, I., Tanyel, F.C., Büyükpamukçu, N., Hiçsönmez, A. The Journal of cardiovascular surgery. (1998) [Pubmed]
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