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Gene Review:

CRISP2 - cysteine-rich secretory protein 2

Bos taurus

This record was replaced with 512443.

Gomyo, H. et al., Walden, P.D. et al., Flowers, K.M. et al., Huang, Z. et al., Vogel, T. et al., et al.

Elliott, Venables, Newton, Lawson, Boyle, Eperon, Cooke,

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High impact information on TPX1

The existence of an additional testis-specific hnRNP G family member provides evidence for the importance of these proteins in normal germ cell development [1].
The testis-specific MAST205 RNA increases in abundance during prepuberal testis development, peaking at the spermatid stage [2].
A novel 205-kilodalton testis-specific serine/threonine protein kinase associated with microtubules of the spermatid manchette [2].
Molecular characterization of a testis-specific estrogen sulfotransferase and aberrant liver expression in obese and diabetogenic C57BL/KsJ-db/db mice [3].
The TSPY gene is conserved in placental mammals and encodes the testis-specific protein, Y encoded [4].

Biological context of TPX1

The Y-chromosomal gene TSPY (testis-specific protein Y-encoded) is probably involved in early spermatogenesis and has a variable copy number in different mammalian species [5].
We determined the chromosomal location of TSPY, the testis-specific protein, Y-encoded, by fluorescence in situ hybridization (FISH) to chromosome spreads of cattle, goat and sheep [6].
Examination of the promoter region of the gene reveals a consensus binding site for the alpha-Pal transcription factor as well as possible cytokine-response elements and binding sites for testis-specific transcription factors [7].

Anatomical context of TPX1

Serine/threonine phosphatase PP1gamma2 is a testis-specific protein phosphatase isoform in spermatozoa [8].

Other interactions of TPX1

Cloning and sequencing of cDNA encoding for the testis-specific fox (Vulpes vulpes) sperm polypeptide Vb of the cytochrome C oxidase [9].

Analytical, diagnostic and therapeutic context of TPX1

Northern blot analyses of SubH2Bv mRNA expression showed that it is testis-specific and is also present in murid testes [10].
Sequence analysis of 5 clones, which spans 23% (458,738 bp) of the region, and extensive gene scanning along the entire region revealed that the region is extraordinarily scarce in genes, but we identified one ubiquitously expressed novel gene and one testis-specific gene fragment [11].

References

An evolutionarily conserved germ cell-specific hnRNP is encoded by a retrotransposed gene. Elliott, D.J., Venables, J.P., Newton, C.S., Lawson, D., Boyle, S., Eperon, I.C., Cooke, H.J. Hum. Mol. Genet. (2000) [Pubmed]
A novel 205-kilodalton testis-specific serine/threonine protein kinase associated with microtubules of the spermatid manchette. Walden, P.D., Cowan, N.J. Mol. Cell. Biol. (1993) [Pubmed]
Molecular characterization of a testis-specific estrogen sulfotransferase and aberrant liver expression in obese and diabetogenic C57BL/KsJ-db/db mice. Song, W.C., Moore, R., McLachlan, J.A., Negishi, M. Endocrinology (1995) [Pubmed]
Tspy is nonfunctional in the Mongolian gerbil but functional in the Syrian hamster. Karwacki, V., Kovac, J., Mauceri, G., Backhaus, A., Föhse, L., Schmidtke, J., Schubert, S. Genomics (2006) [Pubmed]
Organization and concerted evolution of the ampliconic Y-chromosomal TSPY genes from cattle. Verkaar, E.L., Zijlstra, C., van 't Veld, E.M., Boutaga, K., van Boxtel, D.C., Lenstra, J.A. Genomics (2004) [Pubmed]
Conserved Y-chromosomal location of TSPY in Bovidae. Vogel, T., Borgmann, S., Dechend, F., Hecht, W., Schmidtke, J. Chromosome Res. (1997) [Pubmed]
Cloning and characterization of complementary and genomic DNAs encoding the epsilon-subunit of rat translation initiation factor-2B. Flowers, K.M., Mellor, H., Matts, R.L., Kimball, S.R., Jefferson, L.S. Biochim. Biophys. Acta (1996) [Pubmed]
Sperm PP1gamma2 is regulated by a homologue of the yeast protein phosphatase binding protein sds22. Huang, Z., Khatra, B., Bollen, M., Carr, D.W., Vijayaraghavan, S. Biol. Reprod. (2002) [Pubmed]
Cloning and sequencing of cDNA encoding for the testis-specific fox (Vulpes vulpes) sperm polypeptide Vb of the cytochrome C oxidase. Verdier, Y., Farré, G., Rouet, N., Kele, Z., Janáky, T., Boué, F. J. Androl. (2005) [Pubmed]
The major subacrosomal occupant of bull spermatozoa is a novel histone H2B variant associated with the forming acrosome during spermiogenesis. Aul, R.B., Oko, R.J. Dev. Biol. (2002) [Pubmed]
A 2-Mb sequence-ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LOH region of chromosome 11q23.2. Gomyo, H., Arai, Y., Tanigami, A., Murakami, Y., Hattori, M., Hosoda, F., Arai, K., Aikawa, Y., Tsuda, H., Hirohashi, S., Asakawa, S., Shimizu, N., Soeda, E., Sakaki, Y., Ohki, M. Genomics (1999) [Pubmed]

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