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Gene Review

BMP15  -  bone morphogenetic protein 15

Bos taurus

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High impact information on BMP15

  • These results are the first to demonstrate that oocyte-secreted factors, and particularly BMP15 and BMP6, maintain the low incidence of cumulus cell apoptosis by establishing a localized gradient of bone morphogenetic proteins [1].
  • Follistatin and a BMP6 neutralizing antibody, which antagonized the anti-apoptotic effects of BMP15 and BMP6, respectively, whether alone or combined, blocked approximately 50% of the anti-apoptotic actions of oocytes [1].
  • BMP15 alone, GDF9 alone or the two combined all (P<0.05) increased the proportion of oocytes that reached the blastocyst stage post-insemination from 41% (controls) to 58%, 50% and 55%, respectively [2].
  • Maternal MATER, ZAR1, GDF9, and BMP15 transcripts persisted during oocyte in vitro maturation and fertilization and in preimplantation embryo until the five- to eight-cell or morula stage, but transcription was not reactivated at the time of embryonic genome activation [3].
  • Animals heterozygous for the GDF9 and/or the BMP15 mutations have higher ovulation rates than their wild-type counterparts [4].

Biological context of BMP15

  • DO, BMP15 and BMP6 were also able to protect cumulus cells from undergoing apoptosis induced by staurosporine [1].
  • Depending on the GDF9 and/or BMP15 vaccine formulation, ovulation rate was either increased or suppressed [4].
  • Currently, five different point mutations have been identified in the BMP15 (GDF9b) gene and one in GDF9 [4].

Anatomical context of BMP15


  1. Oocytes prevent cumulus cell apoptosis by maintaining a morphogenic paracrine gradient of bone morphogenetic proteins. Hussein, T.S., Froiland, D.A., Amato, F., Thompson, J.G., Gilchrist, R.B. J. Cell. Sci. (2005) [Pubmed]
  2. Oocyte-secreted factors enhance oocyte developmental competence. Hussein, T.S., Thompson, J.G., Gilchrist, R.B. Dev. Biol. (2006) [Pubmed]
  3. Spatio-temporal expression of the germ cell marker genes MATER, ZAR1, GDF9, BMP15,andVASA in adult bovine tissues, oocytes, and preimplantation embryos. Pennetier, S., Uzbekova, S., Perreau, C., Papillier, P., Mermillod, P., Dalbiès-Tran, R. Biol. Reprod. (2004) [Pubmed]
  4. Meat and Livestock Association Plenary Lecture 2005. Oocyte signalling molecules and their effects on reproduction in ruminants. McNatty, K.P., Lawrence, S., Groome, N.P., Meerasahib, M.F., Hudson, N.L., Whiting, L., Heath, D.A., Juengel, J.L. Reprod. Fertil. Dev. (2006) [Pubmed]
  5. Bone morphogenetic protein 15 and growth differentiation factor 9 co-operate to regulate granulosa cell function in ruminants. McNatty, K.P., Juengel, J.L., Reader, K.L., Lun, S., Myllymaa, S., Lawrence, S.B., Western, A., Meerasahib, M.F., Mottershead, D.G., Groome, N.P., Ritvos, O., Laitinen, M.P. Reproduction (2005) [Pubmed]
  6. Genes preferentially expressed in bovine oocytes revealed by subtractive and suppressive hybridization. Pennetier, S., Uzbekova, S., Guyader-Joly, C., Humblot, P., Mermillod, P., Dalbiès-Tran, R. Biol. Reprod. (2005) [Pubmed]
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