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Gene Review

Syb  -  Synaptobrevin

Drosophila melanogaster

Synonyms: 21.15, CG12210, Dmel\CG12210, SYB, VAMP, ...
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Disease relevance of Syb


High impact information on Syb


Biological context of Syb


Anatomical context of Syb


Associations of Syb with chemical compounds

  • The Drosophila and Torpedo proteins show 61 and 81% amino acid identity to mouse SNAP-25, a degree of conservation similar to that previously reported for synaptobrevin [4].


  1. Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects. Sweeney, S.T., Broadie, K., Keane, J., Niemann, H., O'Kane, C.J. Neuron (1995) [Pubmed]
  2. A synaptic vesicle membrane protein is conserved from mammals to Drosophila. Südhof, T.C., Baumert, M., Perin, M.S., Jahn, R. Neuron (1989) [Pubmed]
  3. Members of the synaptobrevin/vesicle-associated membrane protein (VAMP) family in Drosophila are functionally interchangeable in vivo for neurotransmitter release and cell viability. Bhattacharya, S., Stewart, B.A., Niemeyer, B.A., Burgess, R.W., McCabe, B.D., Lin, P., Boulianne, G., O'Kane, C.J., Schwarz, T.L. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. Evolutionary conservation of synaptosome-associated protein 25 kDa (SNAP-25) shown by Drosophila and Torpedo cDNA clones. Risinger, C., Blomqvist, A.G., Lundell, I., Lambertsson, A., Nässel, D., Pieribone, V.A., Brodin, L., Larhammar, D. J. Biol. Chem. (1993) [Pubmed]
  5. Identification and characterization of Drosophila genes for synaptic vesicle proteins. DiAntonio, A., Burgess, R.W., Chin, A.C., Deitcher, D.L., Scheller, R.H., Schwarz, T.L. J. Neurosci. (1993) [Pubmed]
  6. SNARE-dependent signaling at the Drosophila wing margin. Stewart, B.A., Mohtashami, M., Zhou, L., Trimble, W.S., Boulianne, G.L. Dev. Biol. (2001) [Pubmed]
  7. Differential expression of transcripts from syb, a Drosophila melanogaster gene encoding VAMP (synaptobrevin) that is abundant in non-neuronal cells. Chin, A.C., Burgess, R.W., Wong, B.R., Schwarz, T.L., Scheller, R.H. Gene (1993) [Pubmed]
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