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Gene Review:

KERA - keratocan

Gallus gallus

Conrad, A.H. et al., Sundarraj, N. et al., Dunlevy, J.R. et al., Corpuz, L.M. et al.

Conrad, Conrad,

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High impact information on KERA

Results showed that all of the peptides sequenced aligned to the deduced amino acid sequence of either chick lumican or chick keratocan at the first, third, and fourth potential N-linked sites [1].
Early limb buds express Kera mRNA throughout their mesenchyme, then in restricted proximal and distal mesenchymes [2].
Embryonic chick in situ hybridization reveals Kera mRNA expression in corneal endothelium from embryonic day (E) 4.5, Hamburger-Hamilton (HH) 25, in stromal keratocytes from E6.5, HH30, and in iris distal surface cells from E8, HH34 [2].
Kera expression in the trunk at E3.5, HH22 and E4.5, HH25, is strong in dorsolateral subepidermal, sclerotomal and nephrogenic mesenchymes, but absent in neural tube, dorsal root ganglia, nerve outgrowths, notochord, heart and gut [2].
We have cloned and sequenced the cDNAs for quail cornea keratan sulfate proteoglycan core proteins, keratocan and mimecan [3].

Anatomical context of KERA

The corneas were harvested at different times after wounding and processed for either histochemical analyses using periodic acid-Schiff's reaction (PAS) or for indirect immunofluorescence analyses of lumican, keratocan, keratan sulfate, perlecan and laminin [4].

Associations of KERA with chemical compounds

Identification of the N-linked oligosaccharide sites in chick corneal lumican and keratocan that receive keratan sulfate [1].

Analytical, diagnostic and therapeutic context of KERA

Molecular cloning and relative tissue expression of keratocan and mimecan in embryonic quail cornea [3].
No differences were evident in the immunofluorescence for keratocan or keratan sulfate in the scar tissue, but the scar tissue did contain markedly decreased levels of lumican [4].

References

Identification of the N-linked oligosaccharide sites in chick corneal lumican and keratocan that receive keratan sulfate. Dunlevy, J.R., Neame, P.J., Vergnes, J.P., Hassell, J.R. J. Biol. Chem. (1998) [Pubmed]
The keratocan gene is expressed in both ocular and non-ocular tissues during early chick development. Conrad, A.H., Conrad, G.W. Matrix Biol. (2003) [Pubmed]
Molecular cloning and relative tissue expression of keratocan and mimecan in embryonic quail cornea. Corpuz, L.M., Dunlevy, J.R., Hassell, J.R., Conrad, A.H., Conrad, G.W. Matrix Biol. (2000) [Pubmed]
Proteoglycan distribution during healing of corneal stromal wounds in chick. Sundarraj, N., Fite, D., Belak, R., Sundarraj, S., Rada, J., Okamoto, S., Hassell, J. Exp. Eye Res. (1998) [Pubmed]

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