The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

KERA  -  keratocan

Bos taurus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on KERA

  • Keratocytes in the corneal stroma express keratan sulfate-containing proteoglycans including cornea-specific keratocan [1].
  • Keratocytes normally express high levels of aldehyde dehydrogenase and keratocan [2].
  • Keratocan expression of murine keratocytes is maintained on amniotic membrane by down-regulating transforming growth factor-beta signaling [1].
  • In contrast, cells expanded on human amniotic membrane (AM) stromal matrix maintained a three-dimensional dendritic morphology and expressed keratocan mRNA and protein for at least 8 passages before senescence [1].
  • Bovine cornea contains three unique keratan sulfate proteoglycans (KSPGs), of which two (lumican and keratocan) have been characterized using molecular cloning [3].

Biological context of KERA


Anatomical context of KERA


Associations of KERA with chemical compounds


Other interactions of KERA


Analytical, diagnostic and therapeutic context of KERA


  1. Keratocan expression of murine keratocytes is maintained on amniotic membrane by down-regulating transforming growth factor-beta signaling. Kawakita, T., Espana, E.M., He, H., Hornia, A., Yeh, L.K., Ouyang, J., Liu, C.Y., Tseng, S.C. J. Biol. Chem. (2005) [Pubmed]
  2. Maintenance of the keratocyte phenotype during cell proliferation stimulated by insulin. Musselmann, K., Alexandrou, B., Kane, B., Hassell, J.R. J. Biol. Chem. (2005) [Pubmed]
  3. Mimecan, the 25-kDa corneal keratan sulfate proteoglycan, is a product of the gene producing osteoglycin. Funderburgh, J.L., Corpuz, L.M., Roth, M.R., Funderburgh, M.L., Tasheva, E.S., Conrad, G.W. J. Biol. Chem. (1997) [Pubmed]
  4. Molecular cloning and tissue distribution of keratocan. Bovine corneal keratan sulfate proteoglycan 37A. Corpuz, L.M., Funderburgh, J.L., Funderburgh, M.L., Bottomley, G.S., Prakash, S., Conrad, G.W. J. Biol. Chem. (1996) [Pubmed]
  5. Cloning, characterization and tissue-specific expression of the gene encoding bovine keratocan, a corneal keratan sulfate proteoglycan. Tasheva, E.S., Funderburgh, J.L., Corpuz, L.M., Conrad, G.W. Gene (1998) [Pubmed]
  6. Stimulation of collagen synthesis by insulin and proteoglycan accumulation by ascorbate in bovine keratocytes in vitro. Musselmann, K., Kane, B., Alexandrou, B., Hassell, J.R. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  7. Production of prostaglandin D synthase as a keratan sulfate proteoglycan by cultured bovine keratocytes. Berryhill, B.L., Beales, M.P., Hassell, J.R. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  8. Loss of Alpha3(IV) Collagen Expression Associated with Corneal Keratocyte Activation. Guerriero, E., Chen, J., Sado, Y., Mohan, R.R., Wilson, S.E., Funderburgh, J.L., Sundarraj, N. Invest. Ophthalmol. Vis. Sci. (2007) [Pubmed]
WikiGenes - Universities