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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

ord  -  orientation disruptor

Drosophila melanogaster

Synonyms: CG3134, Dmel\CG3134, ORD, Ord, Orientation disrupter protein, ...
 
 
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High impact information on ord

  • Additionally, these data suggest that the meiotic mutations ord and mel-S332 sometimes cause premature "doubling" of the kinetochore region though, as discussed, possibly for a trivial reason [1].
  • However, Ring chromosome recovery is dramatically reduced in ord oocytes compared with wild type, which is consistent with the model that defects in meiotic cohesion remove the constraints that normally limit recombination between sisters [2].
  • Null mutations in orientation disruptor (ord) ablate arm and centromeric cohesion during Drosophila meiosis and severely reduce homologous crossovers in mutant oocytes [2].
  • Although synaptonemal complex (SC) components initially associate with synapsed homologues in ord mutants, their localization is severely disrupted during pachytene progression, and normal tripartite SC is not visible by electron microscopy [2].
  • We conclude that ORD activity suppresses sister chromatid exchange and stimulates inter-homologue crossovers, thereby promoting homologue bias during meiotic recombination in Drosophila [2].
 

Biological context of ord

  • The Drosophila mei-S332 and ord gene products are essential for proper sister-chromatid cohesion during meiosis in both males and females [3].
  • We demonstrate that ord is not required for MEI-S332 protein to localize to meiotic centromeres [3].
  • Analysis of sex chromosome segregation in the double mutant indicates that ord is epistatic to mei-S332 [3].
  • Although overexpression of either protein in a wild-type background does not interfere with normal meiotic chromosome segregation, extra ORD+ protein in mei-S332 mutant males enhances nondisjunction at meiosis II [3].
  • Null ord mutations result in random segregation of sister chromatids during both meiotic divisions because cohesion is completely abolished prior to kinetochore capture of microtubules during meiosis I [4].
 

Anatomical context of ord

 

Other interactions of ord

  • We show that a missense mutation in ORD completely ablates the two-hybrid interaction with dRING and prevents nuclear retention of the mutant ORD protein in male meiotic cells [4].
 

Analytical, diagnostic and therapeutic context of ord

References

 
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