The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

BARF0  -  putative BARF0 protein

Human herpesvirus 4

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of BARF0


High impact information on BARF0


Biological context of BARF0

  • These transcripts include several distinctly spliced forms which are 3'-end coterminal and contain the BamHI A rightward frame 0 (BARF0) open reading frame (ORF) in the final exon [6].
  • Analysis of Epstein-Barr virus transcription in situ in parotid carcinoma specimens revealed that the EBER RNAs, latent membrane protein mRNA, and the BamHI-A rightward reading frame, BARF0, are expressed in the malignant epithelial cells [7].
  • In this study, a rabbit antiserum to a synthetic peptide representing an amino acid sequence encoded by the BARF0 ORF was prepared [8].
  • Since the se transcripts arise from a 22-kbp segment of the EBV genome and construction of large deletion mutants is an improbable result after transfection of infected cells with an EBV DNA fragment with a large deletion mutation, a new approach was taken to make a recombinant with the DNA encoding all of the BARF0 RNAs deleted [9].
  • A large segment of EBV DNA was deleted from the transfected cosmid DNAs by omitting a cosmid which included all of the DNA encoding the BARF0 RNA and by ligating the distal halves of the two flanking cosmids so as to create one cosmid which had ends that overlapped with the other two unaltered cosmids [9].

Anatomical context of BARF0


Associations of BARF0 with chemical compounds

  • This antiserum detected a glutathione S-transferase-BARF0 fusion protein and both BARF0 and RK-BARF0 proteins expressed from transfected constructs in H1299 cells [8].

Other interactions of BARF0

  • The BARTs detected were shown possibly to encode the RPMS1 and BARF0 proteins, based on their splicing [10].

Analytical, diagnostic and therapeutic context of BARF0


  1. Updated Epstein-Barr virus (EBV) DNA sequence and analysis of a promoter for the BART (CST, BARF0) RNAs of EBV. de Jesus, O., Smith, P.R., Spender, L.C., Elgueta Karstegl, C., Niller, H.H., Huang, D., Farrell, P.J. J. Gen. Virol. (2003) [Pubmed]
  2. Epstein-Barr virus-encoded poly(A)(-) RNA supports Burkitt's lymphoma growth through interleukin-10 induction. Kitagawa, N., Goto, M., Kurozumi, K., Maruo, S., Fukayama, M., Naoe, T., Yasukawa, M., Hino, K., Suzuki, T., Todo, S., Takada, K. EMBO J. (2000) [Pubmed]
  3. An Epstein-Barr virus protein interacts with Notch. Kusano, S., Raab-Traub, N. J. Virol. (2001) [Pubmed]
  4. CD21-mediated entry and stable infection by Epstein-Barr virus in canine and rat cells. Yang, L., Maruo, S., Takada, K. J. Virol. (2000) [Pubmed]
  5. Identification of a cytotoxic T-lymphocyte response to the novel BARF0 protein of Epstein-Barr virus: a critical role for antigen expression. Kienzle, N., Sculley, T.B., Poulsen, L., Buck, M., Cross, S., Raab-Traub, N., Khanna, R. J. Virol. (1998) [Pubmed]
  6. Structural analyses of the Epstein-Barr virus BamHI A transcripts. Sadler, R.H., Raab-Traub, N. J. Virol. (1995) [Pubmed]
  7. Epstein-Barr virus infection in carcinoma of the salivary gland. Raab-Traub, N., Rajadurai, P., Flynn, K., Lanier, A.P. J. Virol. (1991) [Pubmed]
  8. Identification of a novel protein encoded by the BamHI A region of the Epstein-Barr virus. Fries, K.L., Sculley, T.B., Webster-Cyriaque, J., Rajadurai, P., Sadler, R.H., Raab-Traub, N. J. Virol. (1997) [Pubmed]
  9. An Epstein-Barr virus with a 58-kilobase-pair deletion that includes BARF0 transforms B lymphocytes in vitro. Robertson, E.S., Tomkinson, B., Kieff, E. J. Virol. (1994) [Pubmed]
  10. In vivo transcription of the Epstein-Barr virus (EBV) BamHI-A region without associated in vivo BARF0 protein expression in multiple EBV-associated disorders. van Beek, J., Brink, A.A., Vervoort, M.B., van Zijp, M.J., Meijer, C.J., van den Brule, A.J., Middeldorp, J.M. J. Gen. Virol. (2003) [Pubmed]
WikiGenes - Universities