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Gene Review:

RBMY2JP - RNA binding motif protein, Y-linked,...

Homo sapiens

Freije, J.P. et al., Ren, B. et al., Mitchell, M.J. et al., Cardoso, J.C. et al., Inohara-Ochiai, M. et al., et al.

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Disease relevance of RBMY2JP

Gastroprotective peptide trefoil factor family 2 gene is activated by upstream stimulating factor but not by c-Myc in gastrointestinal cancer cells [1].
Both family 1 and family 2 PspA proteins can inhibit complement deposition and confer virulence to a capsular serotype 3 strain of Streptococcus pneumoniae [2].
The monomeric multimetal-binding beta-galactosidase of Saccharopolyspora rectivirgula (srbg), a glycosyl hydrolase family-2 enzyme, has a unique sequence consisting of 192 amino acid residues with no similarity to known proteins [3].

High impact information on RBMY2JP

Evolution of the DAZ gene family suggests that Y-linked DAZ plays little, or a limited, role in spermatogenesis but underlines a recent African origin for human populations [4].
This model was originally inferred from the occurrence of few Y-linked genetic traits, pairing of the X and Y chromosomes during male meiosis and, more recently, the existence of X-Y homologous genes [5].
The complete nucleotide sequence of a 4.3-kilobase DNA segment, containing a complete gene with structure very similar to those of known Family 2 cystatin genes, was determined [6].
This tissue-restricted expression is in marked contrast with the wider distribution of all the other Family 2 cystatins, since cystatin C is expressed in all these tissues and the secretory gland cystatins are present in saliva, seminal plasma, and tears [6].
The cystatin D sequence contains all regions of relevance for cysteine proteinase inhibitory activity and also the 4 cysteine residues that form disulfide bridges in the other members of cystatin Family 2 [6].

Biological context of RBMY2JP

We therefore hypothesize that Y-linked DAZ plays little, or a limited, role in human spermatogenesis [4].
Deletion and insertion of a 192-residue peptide in the active-site domain of glycosyl hydrolase family-2 beta-galactosidases [3].
CONCLUSION: The family 2 GPCR members provide a good example of gene duplication events occurring in tandem with increasing organismal complexity during metazoan evolution [7].
RESULTS: Family 2 GPCR members were identified in the invertebrate genomes of the nematodes C. elegans and C. briggsae, the arthropods D. melanogaster and A. gambiae (mosquito) and in the tunicate C. intestinalis [7].

Associations of RBMY2JP with chemical compounds

A mutant form of the family 2 PspA with a deletion within the choline-binding region was also produced [2].

References

Gastroprotective peptide trefoil factor family 2 gene is activated by upstream stimulating factor but not by c-Myc in gastrointestinal cancer cells. Al-azzeh, E., Dittrich, O., Vervoorts, J., Blin, N., Gött, P., Lüscher, B. Gut (2002) [Pubmed]
Both family 1 and family 2 PspA proteins can inhibit complement deposition and confer virulence to a capsular serotype 3 strain of Streptococcus pneumoniae. Ren, B., Szalai, A.J., Thomas, O., Hollingshead, S.K., Briles, D.E. Infect. Immun. (2003) [Pubmed]
Deletion and insertion of a 192-residue peptide in the active-site domain of glycosyl hydrolase family-2 beta-galactosidases. Inohara-Ochiai, M., Hasegawa, S., Iguchi, S., Ashikari, T., Shibano, Y., Hemmi, H., Nakayama, T., Nishino, T. J. Biosci. Bioeng. (2002) [Pubmed]
Evolution of the DAZ gene family suggests that Y-linked DAZ plays little, or a limited, role in spermatogenesis but underlines a recent African origin for human populations. Agulnik, A.I., Zharkikh, A., Boettger-Tong, H., Bourgeron, T., McElreavey, K., Bishop, C.E. Hum. Mol. Genet. (1998) [Pubmed]
The origin and loss of the ubiquitin activating enzyme gene on the mammalian Y chromosome. Mitchell, M.J., Wilcox, S.A., Watson, J.M., Lerner, J.L., Woods, D.R., Scheffler, J., Hearn, J.P., Bishop, C.E., Graves, J.A. Hum. Mol. Genet. (1998) [Pubmed]
Structure and expression of the gene encoding cystatin D, a novel human cysteine proteinase inhibitor. Freije, J.P., Abrahamson, M., Olafsson, I., Velasco, G., Grubb, A., López-Otín, C. J. Biol. Chem. (1991) [Pubmed]
Evolution of secretin family GPCR members in the metazoa. Cardoso, J.C., Pinto, V.C., Vieira, F.A., Clark, M.S., Power, D.M. BMC Evol. Biol. (2006) [Pubmed]

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