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Gene Review

rps6-b  -  ribosomal protein S6

Xenopus laevis

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Disease relevance of rps6

  • Ribosomal protein S6 is a component of the eukaryotic 40S ribosomal subunit that becomes phosphorylated on multiple serine residues in response to a variety of mitogens, including insulin, growth factors, and transforming proteins of many oncogenic viruses [1].
  • Phosphorylation of ribosomal protein S6 in NIH 3T3 fibroblasts is dependent on the presence of serum, but after transformation of these cells by Abelson murine leukemia virus (Ab-MuLV), S6 remained highly phosphorylated on serine residues either in the absence or the presence of serum [2].

High impact information on rps6


Biological context of rps6


Anatomical context of rps6


Associations of rps6 with chemical compounds


Other interactions of rps6

  • Previous studies have shown that increased ribosomal protein S6 kinase activity in unfertilized Xenopus eggs can be resolved by DEAE-Sephacel chromatography into two peaks, designated S6 kinase I and S6 kinase II [12].

Analytical, diagnostic and therapeutic context of rps6


  1. Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II. Sturgill, T.W., Ray, L.B., Erikson, E., Maller, J.L. Nature (1988) [Pubmed]
  2. Phosphorylation of ribosomal protein S6 on serine after microinjection of the Abelson murine leukemia virus tyrosine-specific protein kinase into Xenopus oocytes. Maller, J.L., Foulkes, J.G., Erikson, E., Baltimore, D. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  3. Increased phosphorylation of ribosomal protein S6 following microinjection of insulin receptor-kinase into Xenopus oocytes. Maller, J.L., Pike, L.J., Freidenberg, G.R., Cordera, R., Stith, B.J., Olefsky, J.M., Krebs, E.G. Nature (1986) [Pubmed]
  4. Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytes. Cicirelli, M.F., Tonks, N.K., Diltz, C.D., Weiel, J.E., Fischer, E.H., Krebs, E.G. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  5. A purified S6 kinase kinase from Xenopus eggs activates S6 kinase II and autophosphorylates on serine, threonine, and tyrosine residues. Barrett, C.B., Erikson, E., Maller, J.L. J. Biol. Chem. (1992) [Pubmed]
  6. A 32 kDa protein--whose phosphorylation correlates with oncogenic Ras-induced cell cycle arrest in activated Xenopus egg extracts--is identified as ribosomal protein S6. Pian, J.P., Huang, T.L., Tsai, P.C., Shi, J.P., Cu, H., Pan, B.T. J. Cell. Physiol. (2004) [Pubmed]
  7. Transcription inhibitors stimulate translation of 5' TOP mRNAs through activation of S6 kinase and the mTOR/FRAP signalling pathway. Loreni, F., Thomas, G., Amaldi, F. Eur. J. Biochem. (2000) [Pubmed]
  8. Substrate specificity of ribosomal protein S6 kinase II from Xenopus eggs. Erikson, E., Maller, J.L. Second Messengers Phosphoproteins (1988) [Pubmed]
  9. Identification of protein phosphatases 1 and 2B as ribosomal protein S6 phosphatases in vitro and in vivo. Andres, J.L., Johansen, J.W., Maller, J.L. J. Biol. Chem. (1987) [Pubmed]
  10. Antibodies to Xenopus egg S6 kinase II recognize S6 kinase from progesterone- and insulin-stimulated Xenopus oocytes and from proliferating chicken embryo fibroblasts. Erikson, E., Stefanovic, D., Blenis, J., Erikson, R.L., Maller, J.L. Mol. Cell. Biol. (1987) [Pubmed]
  11. Purification and characterization of a novel protein phosphatase highly specific for ribosomal protein S6. Andres, J.L., Maller, J.L. J. Biol. Chem. (1989) [Pubmed]
  12. In vivo phosphorylation and activation of ribosomal protein S6 kinases during Xenopus oocyte maturation. Erikson, E., Maller, J.L. J. Biol. Chem. (1989) [Pubmed]
  13. Ordered multisite phosphorylation of Xenopus ribosomal protein S6 by S6 kinase II. Wettenhall, R.E., Erikson, E., Maller, J.L. J. Biol. Chem. (1992) [Pubmed]
  14. Ribosomal protein S6 from Xenopus laevis ovaries. Isolation, phosphorylation in vivo and cross-reaction with heterologous anti-S6 antibodies. Kalthoff, H., Darmer, D., Towbin, H., Gordon, J., Amons, R., Möller, W., Richter, D. Eur. J. Biochem. (1982) [Pubmed]
  15. The phosphorylation of ribosomal protein S6 from progesterone-stimulated Xenopus laevis oocytes. Kinetic studies and phosphopeptide analysis. Kruppa, J., Darmer, D., Kalthoff, H., Richter, D. Eur. J. Biochem. (1983) [Pubmed]
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