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Gene Review

rps6ka6  -  ribosomal protein S6 kinase, 90kDa,...

Xenopus laevis

Synonyms: pp90rsk4, rps6ka, rps6ka1, rsk4
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Disease relevance of RPS6KA1

  • Amino acids 44-733 of S6KII alpha were expressed in Escherichia coli and the recombinant protein was used to raise antiserum in rabbits [1].
  • In addition, anti-S6 K II serum reacted with activated S6 kinase from chicken embryo fibroblasts stimulated with serum or transformed by Rous sarcoma virus [2].
  • An S6 kinase clone, closely related to S6 kinase II, was subsequently identified and the protein product was expressed in a baculovirus system [3].

High impact information on RPS6KA1


Biological context of RPS6KA1

  • The changes in NEP-B during metaphase did not appear to be regulated directly by either p34cdc2/cyclin B, S6 kinase II or MAP kinase [6].
  • However, it clearly differs from S6 kinase II in that it has only one, rather than two predicted catalytic domains and a deduced molecular mass of 59,109 Da [7].

Anatomical context of RPS6KA1


Associations of RPS6KA1 with chemical compounds


Other interactions of RPS6KA1

  • Previous studies have shown that increased ribosomal protein S6 kinase activity in unfertilized Xenopus eggs can be resolved by DEAE-Sephacel chromatography into two peaks, designated S6 kinase I and S6 kinase II [9].

Analytical, diagnostic and therapeutic context of RPS6KA1


  1. A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases. Jones, S.W., Erikson, E., Blenis, J., Maller, J.L., Erikson, R.L. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  2. Antibodies to Xenopus egg S6 kinase II recognize S6 kinase from progesterone- and insulin-stimulated Xenopus oocytes and from proliferating chicken embryo fibroblasts. Erikson, E., Stefanovic, D., Blenis, J., Erikson, R.L., Maller, J.L. Mol. Cell. Biol. (1987) [Pubmed]
  3. A purified S6 kinase kinase from Xenopus eggs activates S6 kinase II and autophosphorylates on serine, threonine, and tyrosine residues. Barrett, C.B., Erikson, E., Maller, J.L. J. Biol. Chem. (1992) [Pubmed]
  4. MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways. Ballou, L.M., Luther, H., Thomas, G. Nature (1991) [Pubmed]
  5. Sequential activation of MAP kinase activator, MAP kinases, and S6 peptide kinase in intact rat liver following insulin injection. Tobe, K., Kadowaki, T., Hara, K., Gotoh, Y., Kosako, H., Matsuda, S., Tamemoto, H., Ueki, K., Akanuma, Y., Nishida, E. J. Biol. Chem. (1992) [Pubmed]
  6. Regulation of nuclear envelope precursor functions during cell division. Vigers, G.P., Lohka, M.J. J. Cell. Sci. (1992) [Pubmed]
  7. cDNA encoding a 59 kDa homolog of ribosomal protein S6 kinase from rabbit liver. Harmann, B., Kilimann, M.W. FEBS Lett. (1990) [Pubmed]
  8. Purification and characterisation of the insulin-stimulated protein kinase from rabbit skeletal muscle; close similarity to S6 kinase II. Lavoinne, A., Erikson, E., Maller, J.L., Price, D.J., Avruch, J., Cohen, P. Eur. J. Biochem. (1991) [Pubmed]
  9. In vivo phosphorylation and activation of ribosomal protein S6 kinases during Xenopus oocyte maturation. Erikson, E., Maller, J.L. J. Biol. Chem. (1989) [Pubmed]
  10. Evidence for different signalling pathways of PKC zeta and ras-p21 in Xenopus oocytes. Carnero, A., Liyanage, M., Stabel, S., Lacal, J.C. Oncogene (1995) [Pubmed]
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