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Gene Review

NANOGP8  -  Nanog homeobox pseudogene 8

Homo sapiens

Synonyms: NANOG, NANOGP1, PN8
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Disease relevance of NANOGP8

  • Roles of the Nanog protein in murine F9 embryonal carcinoma cells and their endoderm-differentiated counterparts [1].

High impact information on NANOGP8

  • Furthermore, transfection of a constitutive active Mek mutant into ES cells induced Nanog repression and primitive endoderm differentiation [2].
  • These new data support a model wherein Tcf3-mediated control of Nanog levels allows stem cells to balance the creation of lineage-committed and undifferentiated cells [3].
  • Chromatin immunoprecipitation and promoter reporter assays showed that Tcf3 bound to a promoter regulatory region of the Nanog gene and repressed its transcriptional activity in ESC through a Groucho interaction domain-dependent process [3].
  • Of interest, addition of the tyrosine phosphatase inhibitor, sodium vanadate, selectively repressed Nanog transcription without any detectable changes in upstream transcriptional regulators Oct3/4 and Sox2 [2].
  • Indeed, PD98059 prevented Nanog repression induced by ES cell aggregation as well [2].

Biological context of NANOGP8


Anatomical context of NANOGP8

  • In this study, we found that NANOGP8 was expressed in several cancer cell lines and in all cancer tissues tested [5].
  • Analysis of distinct Mus species suggests that NanogPc and NanogPd arose between divergence of M. caroli and M. spretus and indicates that Nanog retrotransposition events continue to occur at a high frequency, a property likely to extend to other germ-line transcripts [6].


  1. Roles of the Nanog protein in murine F9 embryonal carcinoma cells and their endoderm-differentiated counterparts. Chen, Y., Du, Z., Yao, Z. Cell Res. (2006) [Pubmed]
  2. The grb2/mek pathway represses nanog in murine embryonic stem cells. Hamazaki, T., Kehoe, S.M., Nakano, T., Terada, N. Mol. Cell. Biol. (2006) [Pubmed]
  3. Repression of nanog gene transcription by tcf3 limits embryonic stem cell self-renewal. Pereira, L., Yi, F., Merrill, B.J. Mol. Cell. Biol. (2006) [Pubmed]
  4. Evolution of the NANOG pseudogene family in the human and chimpanzee genomes. Fairbanks, D.J., Maughan, P.J. BMC Evol. Biol. (2006) [Pubmed]
  5. NANOGP8 is a retrogene expressed in cancers. Zhang, J., Wang, X., Li, M., Han, J., Chen, B., Wang, B., Dai, J. FEBS J. (2006) [Pubmed]
  6. Nanog retrotransposed genes with functionally conserved open reading frames. Robertson, M., Stenhouse, F., Colby, D., Marland, J.R., Nichols, J., Tweedie, S., Chambers, I. Mamm. Genome (2006) [Pubmed]
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