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Gene Review

T  -  T, brachyury homolog (mouse)

Gallus gallus

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Disease relevance of T


High impact information on T

  • We previously discovered a cellular isoform of titin (originally named T-protein) colocalized with myosin II in the terminal web domain of the chicken intestinal epithelial cell brush border cytoskeleton (Eilertsen, K.J., and T.C.S. Keller. 1992. J. Cell Biol. 119:549-557) [2].
  • One of these novel genes (Ch-TbxT) becomes restricted to the axial mesoderm lineage and is a potential candidate for complementing or extending Brachyury function in the anterior axis (formation of the head process, prechordal plate) [3].
  • Therefore, Brachyury expression may act functionally upstream of cSox3 downregulation. cSox3 expression is also lost from non-neuronal ectoderm shortly after the neural plate becomes morphologically apparent. cSox2 expression increases dramatically in the central nervous system as neural ectoderm is established [4].
  • In the area pellucida, both PN and HN transplants inhibited cell population growth while only PN caudalized the host axis and induced supernumerary primitive streaks expressing the mesoderm-specific gene Brachyury [5].
  • A one-base deletion (183delC) and a missense mutation (D276H) in the T-protein gene from a Japanese family with nonketotic hyperglycinemia [1].

Chemical compound and disease context of T


Anatomical context of T


  1. A one-base deletion (183delC) and a missense mutation (D276H) in the T-protein gene from a Japanese family with nonketotic hyperglycinemia. Kure, S., Shinka, T., Sakata, Y., Osamu, N., Takayanagi, M., Tada, K., Matsubara, Y., Narisawa, K. J. Hum. Genet. (1998) [Pubmed]
  2. Cellular titin localization in stress fibers and interaction with myosin II filaments in vitro. Eilertsen, K.J., Kazmierski, S.T., Keller, T.C. J. Cell Biol. (1994) [Pubmed]
  3. Two novel chick T-box genes related to mouse Brachyury are expressed in different, non-overlapping mesodermal domains during gastrulation. Knezevic, V., De Santo, R., Mackem, S. Development (1997) [Pubmed]
  4. Dynamic expression of chicken Sox2 and Sox3 genes in ectoderm induced to form neural tissue. Rex, M., Orme, A., Uwanogho, D., Tointon, K., Wigmore, P.M., Sharpe, P.T., Scotting, P.J. Dev. Dyn. (1997) [Pubmed]
  5. Post-nodal mesoblast caudalizes the host axis and inhibits cell population growth, and induces new primitive streaks in chick embryos. Joshi-Banka, D., Paranjape, S., Ghaskadbi, S., Modak, S.P. Dev. Growth Differ. (2002) [Pubmed]
  6. The chick Brachyury gene: developmental expression pattern and response to axial induction by localized activin. Kispert, A., Ortner, H., Cooke, J., Herrmann, B.G. Dev. Biol. (1995) [Pubmed]
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