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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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CNP  -  2',3'-cyclic nucleotide 3' phosphodiesterase

Gallus gallus

 
 
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Disease relevance of CNP

  • There was also a significant correlation between decreased CNP activity and the degree of ataxia at the time of maximal locomotor impairment [1].
  • CNP activity was determined utilizing crude homogenates or purified myelin preparations from whole brain, spinal cord, and sciatic nerves at maximal neurologic dysfunction, evaluated as locomotor impairment [2].
 

High impact information on CNP

  • The activity of 2'3'-cyclic nucleotide 3'-phosphohydrolase (CNP) remained low, indicating a low percentage of mature oligodendrocytes [3].
  • This difference was large in case of PCDDs and Co-PCBs, which was explained by the past pollution such as commercial PCB products and PCDD impurities in chloronitrofen (CNP) and pentachlorophenol (PCP) [4].
  • Our work has shown that although both soluble (sGC) and membrane-bound (mGC) forms of guanylyl cyclase are present, the primary contributor to the circadian rhythms of cGMP is the mGC-B enzyme, which is activated only by the natriuretic peptide CNP [5].
  • The level of CNP activity in spinal cord and brain homogenates from TOTP-dosed birds was not markedly altered [1].
  • CNP activity of sciatic nerve preparations from TOTP-dosed hens was significantly inhibited (p less than 0.05) at the time of maximal locomotor impairment [1].
 

Anatomical context of CNP

 

Associations of CNP with chemical compounds

  • The effect of various organophosphorus (OP) compounds on 2', 3'-cyclic nucleotide 3'-phosphohydrolase (CNP) activity and the relationship to neurotoxic response was studied [2].
  • Decreased CNP activity was also noted in spinal cord preparations from DFP-treated hens at the time of maximal locomotor impairment [2].
  • The activity of 2', 3'-cyclic nucleotide 3'-phosphohydrolase (CNP, EC 3.1.4.37), a myelin-associated enzyme, was monitored in brain, spinal cord, and sciatic nerve homogenates from tri-o-tolyl phosphate (TOTP) and tri-m-tolyl phosphate (TMTP) treated hens [1].
  • Enzyme assays of CNP revealed a decrease in brain CNP activity at the time of maximal locomotor impairment after a single, oral dose of leptophos [2].
  • Injections of 1,1,3-tricyano-2-amino-1-propene (TCAP) into chick embryos increases the synthesis of the myelin enzyme 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNP) [7].

References

 
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