The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ITGA1  -  integrin, alpha 1

Gallus gallus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on ITGA1


Anatomical context of ITGA1

  • We have shown previously that attachment of osteoclasts to bone and subsequent resorption are mediated by the integrin alpha v beta 3 [4].
  • The results suggest that integrin alpha subunits are required for cranial neural crest cell attachment and emigration [5].
  • Chick integrin alpha V subunit molecular analysis reveals high conservation of structural domains and association with multiple beta subunits in embryo fibroblasts [6].
  • An antibody against chicken integrin alpha v beta 3, the monoclonal antibody (MAb) 23C6, did not interfere with the adhesion of osteocytes and osteoblasts to matrix proteins, whereas an MAb against chicken integrin subunit beta 1 (CSAT) strongly inhibited adhesion to all substrates [7].

Other interactions of ITGA1


Analytical, diagnostic and therapeutic context of ITGA1


  1. The integrin receptor alpha 8 beta 1 mediates interactions of embryonic chick motor and sensory neurons with tenascin-C. Varnum-Finney, B., Venstrom, K., Muller, U., Kypta, R., Backus, C., Chiquet, M., Reichardt, L.F. Neuron (1995) [Pubmed]
  2. Cranial neural crest recycle surface integrins in a substratum-dependent manner to promote rapid motility. Strachan, L.R., Condic, M.L. J. Cell Biol. (2004) [Pubmed]
  3. Characterization of the integrin alpha 8 subunit: a new integrin beta 1-associated subunit, which is prominently expressed on axons and on cells in contact with basal laminae in chick embryos. Bossy, B., Bossy-Wetzel, E., Reichardt, L.F. EMBO J. (1991) [Pubmed]
  4. 1 alpha,25-dihydroxyvitamin D3 up-regulates expression of the osteoclast integrin alpha v beta 3. Medhora, M.M., Teitelbaum, S., Chappel, J., Alvarez, J., Mimura, H., Ross, F.P., Hruska, K. J. Biol. Chem. (1993) [Pubmed]
  5. Inhibition of cranial neural crest adhesion in vitro and migration in vivo using integrin antisense oligonucleotides. Kil, S.H., Lallier, T., Bronner-Fraser, M. Dev. Biol. (1996) [Pubmed]
  6. Chick integrin alpha V subunit molecular analysis reveals high conservation of structural domains and association with multiple beta subunits in embryo fibroblasts. Bossy, B., Reichardt, L.F. Biochemistry (1990) [Pubmed]
  7. Adhesive properties of isolated chick osteocytes in vitro. Aarden, E.M., Nijweide, P.J., van der Plas, A., Alblas, M.J., Mackie, E.J., Horton, M.A., Helfrich, M.H. Bone (1996) [Pubmed]
  8. Binding of osteopontin to the osteoclast integrin alpha v beta 3. Miyauchi, A., Alvarez, J., Greenfield, E.M., Teti, A., Grano, M., Colucci, S., Zambonin-Zallone, A., Ross, F.P., Teitelbaum, S.L., Cheresh, D. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (1993) [Pubmed]
  9. Laminin receptors in the retina: sequence analysis of the chick integrin alpha 6 subunit. Evidence for transcriptional and posttranslational regulation. de Curtis, I., Quaranta, V., Tamura, R.N., Reichardt, L.F. J. Cell Biol. (1991) [Pubmed]
  10. Integrin alpha v subunit is expressed on mesodermal cell surfaces during amphibian gastrulation. Alfandari, D., Whittaker, C.A., DeSimone, D.W., Darribère, T. Dev. Biol. (1995) [Pubmed]
WikiGenes - Universities