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Gene Review

Itga1  -  integrin, alpha 1

Rattus norvegicus

Synonyms: CD49 antigen-like family member A, Integrin alpha-1, Laminin and collagen receptor, VLA-1
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Disease relevance of Itga1


High impact information on Itga1


Chemical compound and disease context of Itga1


Biological context of Itga1


Anatomical context of Itga1


Associations of Itga1 with chemical compounds


Physical interactions of Itga1


Other interactions of Itga1


Analytical, diagnostic and therapeutic context of Itga1


  1. Treatment with an antibody to VLA-1 integrin reduces glomerular and tubulointerstitial scarring in a rat model of crescentic glomerulonephritis. Cook, H.T., Khan, S.B., Allen, A., Bhangal, G., Smith, J., Lobb, R.R., Pusey, C.D. Am. J. Pathol. (2002) [Pubmed]
  2. Evaluation of the disintegrin, triflavin, in a rat middle cerebral artery thrombosis model. Kaku, S., Umemura, K., Mizuno, A., Kawasaki, T., Nakashima, M. Eur. J. Pharmacol. (1997) [Pubmed]
  3. Expression of fibronectin receptor, integrin alpha 5 beta 1 of hepatic stellate cells in rat liver fibrosis. Zhou, X., Zhang, Y., Zhang, J., Zhu, H., Zhou, X., Du, W., Zhang, X., Chen, Q. Chin. Med. J. (2000) [Pubmed]
  4. Inhibition of nuclear hormone receptor activity by calreticulin. Dedhar, S., Rennie, P.S., Shago, M., Hagesteijn, C.Y., Yang, H., Filmus, J., Hawley, R.G., Bruchovsky, N., Cheng, H., Matusik, R.J. Nature (1994) [Pubmed]
  5. Identification of integrin alpha 3 beta 1 as a neuronal thrombospondin receptor mediating neurite outgrowth. DeFreitas, M.F., Yoshida, C.K., Frazier, W.A., Mendrick, D.L., Kypta, R.M., Reichardt, L.F. Neuron (1995) [Pubmed]
  6. Temporal changes in the expression and distribution of adhesion molecules during liver development and regeneration. Stamatoglou, S.C., Enrich, C., Manson, M.M., Hughes, R.C. J. Cell Biol. (1992) [Pubmed]
  7. Molecular cloning of the rat integrin alpha 1-subunit: a receptor for laminin and collagen. Ignatius, M.J., Large, T.H., Houde, M., Tawil, J.W., Barton, A., Esch, F., Carbonetto, S., Reichardt, L.F. J. Cell Biol. (1990) [Pubmed]
  8. Changes in cell surface expression of fibronectin and fibronectin receptor during liver regeneration. Pujades, C., Forsberg, E., Enrich, C., Johansson, S. J. Cell. Sci. (1992) [Pubmed]
  9. Studies on the role of platelet eicosanoid metabolism and integrin alpha IIb beta 3 in tumor-cell-induced platelet aggregation. Steinert, B.W., Tang, D.G., Grossi, I.M., Umbarger, L.A., Honn, K.V. Int. J. Cancer (1993) [Pubmed]
  10. Synchronous appearance of fibronectin, integrin alpha 5 beta 1, vinculin and actin in epithelial cells and fibroblasts during rat tracheal wound healing. Horiba, K., Fukuda, Y. Virchows Arch. (1994) [Pubmed]
  11. A developmental analysis of oligodendroglial integrins in primary cells: changes in alpha v-associated beta subunits during differentiation. Milner, R., Ffrench-Constant, C. Development (1994) [Pubmed]
  12. Expression of integrin alpha 1 beta 1 is regulated by nerve growth factor and dexamethasone in PC12 cells. Functional consequences for adhesion and neurite outgrowth. Zhang, Z., Tarone, G., Turner, D.C. J. Biol. Chem. (1993) [Pubmed]
  13. Bidirectional signaling between sarcoglycans and the integrin adhesion system in cultured L6 myocytes. Yoshida, T., Pan, Y., Hanada, H., Iwata, Y., Shigekawa, M. J. Biol. Chem. (1998) [Pubmed]
  14. Localization of two fibronectin-binding glycoproteins in rat liver and primary hepatocytes. Co-distribution in vitro of integrin (alpha 5 beta 1) and non-integrin (AGp110) receptors in cell-substratum adhesion sites. Stamatoglou, S.C., Sullivan, K.H., Johansson, S., Bayley, P.M., Burdett, I.D., Hughes, R.C. J. Cell. Sci. (1990) [Pubmed]
  15. Distribution of fibronectin and fibronectin-binding proteins, AGp110 and integrin alpha 5 beta 1, during chemically induced hepatocarcinogenesis in adult rats. Stamatoglou, S.C., Manson, M.M., Green, J.A., Mayol, X., Hughes, R.C. J. Cell. Sci. (1991) [Pubmed]
  16. Nerve growth factor induces increased expression of a laminin-binding integrin in rat pheochromocytoma PC12 cells. Rossino, P., Gavazzi, I., Timpl, R., Aumailley, M., Abbadini, M., Giancotti, F., Silengo, L., Marchisio, P.C., Tarone, G. Exp. Cell Res. (1990) [Pubmed]
  17. Ligation of endothelial alpha v beta 3 integrin increases capillary hydraulic conductivity of rat lung. Tsukada, H., Ying, X., Fu, C., Ishikawa, S., McKeown-Longo, P., Albelda, S., Bhattacharya, S., Bray, B.A., Bhattacharya, J. Circ. Res. (1995) [Pubmed]
  18. Glomerular epithelial and mesangial cells differentially modulate the binding specificities of VLA-1 and VLA-2. Mendrick, D.L., Kelly, D.M., duMont, S.S., Sandstrom, D.J. Lab. Invest. (1995) [Pubmed]
  19. Expression of cell adhesion molecule and albumin genes in primary culture of rat hepatocytes. Hou, D.X., Arimura, M., Fukuda, M., Oka, T., Fujii, M. Cell Biol. Int. (2001) [Pubmed]
  20. Identification of a neuronal laminin receptor: an Mr 200K/120K integrin heterodimer that binds laminin in a divalent cation-dependent manner. Ignatius, M.J., Reichardt, L.F. Neuron (1988) [Pubmed]
  21. Affinity of integrin alpha 1 beta 1 from liver sinusoidal membranes for type IV collagen. Stamatoglou, S.C., Bawumia, S., Johansson, S., Forsberg, E., Hughes, R.C. FEBS Lett. (1991) [Pubmed]
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