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Gene Review

Itga1  -  integrin alpha 1

Mus musculus

Synonyms: CD49 antigen-like family member A, CD49A, E130012M19Rik, Integrin alpha-1, Laminin and collagen receptor, ...
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Disease relevance of Itga1


High impact information on Itga1


Biological context of Itga1


Anatomical context of Itga1

  • Cytofluorometric analysis and immunoprecipitation showed that the alpha 2 subunit is an abundant integrin alpha subunit in the endothelial cells and that the alpha subunits associated with laminin binding in other types of cells are expressed in these cells only at low levels [14].
  • Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice [15].
  • The mucosal lymphocyte integrin alpha E(CD103)beta 7 is thought to be important for intraepithelial lymphocyte (IEL) localization or function [15].
  • Native EHS laminin uses integrin alpha 1 beta 1 for hepatocyte binding to the center of the cross (fragment P1) and other beta 1 integrin(s) in addition to alpha 1 beta 1 as receptors for the distal part of the long arm (fragment E8) [16].
  • As beta1 integrins are a major class of receptors for basal lamina components, we stained muscles with antibodies to the 10 integrin alpha subunits known to form dimers with beta1, to determine if any of these molecules were concentrated at synaptic sites on muscle fibers [17].

Associations of Itga1 with chemical compounds

  • Integrin alpha 1 beta 1 is a collagen receptor expressed on many mesenchymal cells, but mice deficient in alpha 1 integrin (alpha1-KO) have no gross structural defects [18].
  • Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans [19].
  • Binding to laminin-1 was abolished by EDTA and could be specifically inhibited by antibodies to the respective integrin alpha subunit [20].
  • In the airways, where type IV collagen is abundant, but not the spleen, the CD49a(+) CD8 cells had reduced proportions of annexin V and caspase 8, and >80% expressed the TNF-alpha receptor II, while Fas, TNFR-I, and CD27 expression were similar to CD49a(-) cells [21].

Physical interactions of Itga1


Regulatory relationships of Itga1

  • Control of myeloid-specific integrin alpha Mbeta 2 (CD11b/CD18) expression by cytokines is regulated by Stat3-dependent activation of PU.1 [22].

Other interactions of Itga1

  • The Vla1 locus is located 3.5 cM distal to Ctla-3 and 7.8 cM distal to Htrla [12].
  • We cloned the murine integrin gene encoding alpha E, localized it to chromosome 11, and generated integrin alpha E-deficient mice [15].
  • Integrin alpha 1 and integrin alpha 2, which map to the same general region, are possible candidate loci, based on their embryonic expression and cellular function [23].
  • To further examine the role of the integrin alpha subunit in these signaling functions, we assessed the contribution of the alpha 6 cytoplasmic domain variants to the signaling properties of the alpha 6 beta 1 integrin using P388D1 cells that had been transfected with either the alpha 6A or the alpha 6B cDNA [24].
  • While the functions of integrin alpha chain cytoplasmic domains are not understood, it is possible that they contribute to transferring signals to the cell interior, e.g., by delivering cytoskeleton organizing signals in response to integrin engagement with extracellular matrix ligands [25].

Analytical, diagnostic and therapeutic context of Itga1

  • Sequence analysis of rat integrin alpha E1 and alpha E2 subunits: tissue expression reveals phenotypic similarities between intraepithelial lymphocytes and dendritic cells in lymph [26].
  • Lung fibrosis was induced by a single intratracheal instillation of BLM (0.125 U.mouse-1), and bronchoalveolar lavage (BAL) T-cell subpopulations were examined at various time-points for the expression of the integrin alpha E beta 7 by flow cytometry [1].
  • These findings demonstrate that integrin alpha 5 beta 1 expression in the absence of attachment to fibronectin activates a signaling pathway leading to decreased cellular proliferation and that ligation of this receptor with fibronectin reverses this signal, thereby contributing to the proliferation of transformed cells [27].
  • Homology PCR is a powerful technique for the identification of known and novel integrin alpha and beta subunit cDNAs in cells from the lung and other organs [28].


  1. Integrin alpha E beta 7 expression on BAL CD4+, CD8+, and gamma delta T-cells in bleomycin-induced lung fibrosis in mouse. Braun, R.K., Sterner-Kock, A., Kilshaw, P.J., Ferrick, D.A., Giri, S.N. Eur. Respir. J. (1996) [Pubmed]
  2. Control of thrombus embolization and fibronectin internalization by integrin alpha IIb beta 3 engagement of the fibrinogen gamma chain. Ni, H., Papalia, J.M., Degen, J.L., Wagner, D.D. Blood (2003) [Pubmed]
  3. An abundant chick gizzard integrin is the avian alpha 1 beta 1 integrin heterodimer and functions as a divalent cation-dependent collagen IV receptor. Syfrig, J., Mann, K., Paulsson, M. Exp. Cell Res. (1991) [Pubmed]
  4. Phenotypic properties of cultured tumor cells: integrin alpha IIb beta 3 expression, tumor-cell-induced platelet aggregation, and tumor-cell adhesion to endothelium as important parameters of experimental metastasis. Tang, D.G., Onoda, J.M., Steinert, B.W., Grossi, I.M., Nelson, K.K., Umbarger, L., Diglio, C.A., Taylor, J.D., Honn, K.V. Int. J. Cancer (1993) [Pubmed]
  5. The lipoxygenase metabolite 12(S)-HETE induces a cytoskeleton-dependent increase in surface expression of integrin alpha IIb beta 3 on melanoma cells. Chopra, H., Timar, J., Chen, Y.Q., Rong, X.H., Grossi, I.M., Fitzgerald, L.A., Taylor, J.D., Honn, K.V. Int. J. Cancer (1991) [Pubmed]
  6. A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. Wary, K.K., Mariotti, A., Zurzolo, C., Giancotti, F.G. Cell (1998) [Pubmed]
  7. The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. Wary, K.K., Mainiero, F., Isakoff, S.J., Marcantonio, E.E., Giancotti, F.G. Cell (1996) [Pubmed]
  8. Impaired activation of murine platelets lacking G alpha(i2). Jantzen, H.M., Milstone, D.S., Gousset, L., Conley, P.B., Mortensen, R.M. J. Clin. Invest. (2001) [Pubmed]
  9. Primary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signaling. Shiraga, M., Ritchie, A., Aidoudi, S., Baron, V., Wilcox, D., White, G., Ybarrondo, B., Murphy, G., Leavitt, A., Shattil, S. J. Cell Biol. (1999) [Pubmed]
  10. H36-alpha 7 is a novel integrin alpha chain that is developmentally regulated during skeletal myogenesis. Song, W.K., Wang, W., Foster, R.F., Bielser, D.A., Kaufman, S.J. J. Cell Biol. (1992) [Pubmed]
  11. Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion. Gardner, H., Kreidberg, J., Koteliansky, V., Jaenisch, R. Dev. Biol. (1996) [Pubmed]
  12. Genetic mapping of the integrin alpha 1 gene (Vla1) to mouse chromosome 13. Douville, P., Seldin, M.F., Carbonetto, S. Genomics (1992) [Pubmed]
  13. Monoclonal antibodies that block the activity of leukocyte function-associated antigen 1 recognize three discrete epitopes in the inserted domain of CD11a. Champe, M., McIntyre, B.W., Berman, P.W. J. Biol. Chem. (1995) [Pubmed]
  14. Endothelial cells use alpha 2 beta 1 integrin as a laminin receptor. Languino, L.R., Gehlsen, K.R., Wayner, E., Carter, W.G., Engvall, E., Ruoslahti, E. J. Cell Biol. (1989) [Pubmed]
  15. Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice. Schön, M.P., Arya, A., Murphy, E.A., Adams, C.M., Strauch, U.G., Agace, W.W., Marsal, J., Donohue, J.P., Her, H., Beier, D.R., Olson, S., Lefrancois, L., Brenner, M.B., Grusby, M.J., Parker, C.M. J. Immunol. (1999) [Pubmed]
  16. Laminin isoforms promote attachment of hepatocytes via different integrins. Forsberg, E., Lindblom, A., Paulsson, M., Johansson, S. Exp. Cell Res. (1994) [Pubmed]
  17. Synaptic integrins in developing, adult, and mutant muscle: selective association of alpha1, alpha7A, and alpha7B integrins with the neuromuscular junction. Martin, P.T., Kaufman, S.J., Kramer, R.H., Sanes, J.R. Dev. Biol. (1996) [Pubmed]
  18. Diminished callus size and cartilage synthesis in alpha 1 beta 1 integrin-deficient mice during bone fracture healing. Ekholm, E., Hankenson, K.D., Uusitalo, H., Hiltunen, A., Gardner, H., Heino, J., Penttinen, R. Am. J. Pathol. (2002) [Pubmed]
  19. Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans. Chen, N., Chen, C.C., Lau, L.F. J. Biol. Chem. (2000) [Pubmed]
  20. Binding of purified collagen receptors (alpha 1 beta 1, alpha 2 beta 1) and RGD-dependent integrins to laminins and laminin fragments. Pfaff, M., Göhring, W., Brown, J.C., Timpl, R. Eur. J. Biochem. (1994) [Pubmed]
  21. The alpha1beta1 integrin and TNF receptor II protect airway CD8+ effector T cells from apoptosis during influenza infection. Richter, M.V., Topham, D.J. J. Immunol. (2007) [Pubmed]
  22. Control of myeloid-specific integrin alpha Mbeta 2 (CD11b/CD18) expression by cytokines is regulated by Stat3-dependent activation of PU.1. Panopoulos, A.D., Bartos, D., Zhang, L., Watowich, S.S. J. Biol. Chem. (2002) [Pubmed]
  23. The lidgap-Gates (lgGa) mutation for open eyelids at birth maps to mouse chromosome 13. Juriloff, D.M., Harris, M.J., Mah, D.G., Benson, A. Mamm. Genome (1996) [Pubmed]
  24. The alpha 6A beta 1 and alpha 6B beta 1 integrin variants signal differences in the tyrosine phosphorylation of paxillin and other proteins. Shaw, L.M., Turner, C.E., Mercurio, A.M. J. Biol. Chem. (1995) [Pubmed]
  25. The major laminin receptor of mouse embryonic stem cells is a novel isoform of the alpha 6 beta 1 integrin. Cooper, H.M., Tamura, R.N., Quaranta, V. J. Cell Biol. (1991) [Pubmed]
  26. Sequence analysis of rat integrin alpha E1 and alpha E2 subunits: tissue expression reveals phenotypic similarities between intraepithelial lymphocytes and dendritic cells in lymph. Brenan, M., Rees, D.J. Eur. J. Immunol. (1997) [Pubmed]
  27. Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin. Varner, J.A., Emerson, D.A., Juliano, R.L. Mol. Biol. Cell (1995) [Pubmed]
  28. Novel integrin alpha and beta subunit cDNAs identified in airway epithelial cells and lung leukocytes using the polymerase chain reaction. Erle, D.J., Sheppard, D., Breuss, J., Rüegg, C., Pytela, R. Am. J. Respir. Cell Mol. Biol. (1991) [Pubmed]
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