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Gene Review

ITGA1  -  integrin, alpha 1

Homo sapiens

Synonyms: CD49 antigen-like family member A, CD49a, Integrin alpha-1, Laminin and collagen receptor, VLA-1, ...
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Disease relevance of ITGA1


High impact information on ITGA1


Chemical compound and disease context of ITGA1


Biological context of ITGA1


Anatomical context of ITGA1


Associations of ITGA1 with chemical compounds


Physical interactions of ITGA1

  • Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3 [19].
  • Cross-linking experiments showed that the VLA-1 complex is a heterodimer composed of an Mr 210,000 subunit (alpha 1) in acid-labile association with an Mr 130,000 subunit (beta) [23].
  • Immunoprecipitation with anti-integrin alpha 2 antibodies or anti-integrin beta 1 antibody resulted in preferential coprecipitation of EGFR from A431 cell lysates, while anti-EGFR antibody coprecipitated integrin alpha 2 beta 1 [24].
  • Finally, IRS-1 in LNCaP cells co-immunoprecipitates with integrin alpha 5 beta 1, and the association is again IGF-I-independent [25].
  • Thus, the alpha(9) and alpha(4) integrin subunits form a paxillin-binding subfamily of integrin alpha subunits, and direct binding of paxillin to the alpha(9) cytoplasmic domain mediates some of the biological activities of the alpha(9)beta(1) integrin [26].

Co-localisations of ITGA1


Regulatory relationships of ITGA1

  • Nodal follicular center cell lymphomas (FCCL) were VLA-1- and -2- and very rarely expressed VLA-5 and -6 [29].
  • In the peripheral blood, patients with active rheumatoid arthritis expressed VLA-1 on 11.7 +/- 6.0% of their mononuclear cells, compared to 1.9 +/- 1.5% in controls (P less than 0.001) [30].
  • The integrin alpha 4 beta 1 can provide a costimulus to induce IL-2 secretion and IL-2R expression leading to enhanced proliferation of purified, peripheral blood T cells [31].
  • Talin controls the exit of the integrin alpha 5 beta 1 from an early compartment of the secretory pathway [32].
  • In chronic inactive lesions beta1, VLA-6 and alpha(v) were the same as controls but VLA-1 remained increased [22].

Other interactions of ITGA1

  • Cells in the synovial lining layer expressed beta 1, VLA-1, VLA-3 and and VLA-5 [16].
  • Integrin alpha 1 (ITGA1) and WNT5A were also overexpressed [33].
  • VLA-1 to VLA-6 are cell-surface molecules binding to matrix molecules such as collagen, fibronectin, epiligrin, and laminin [29].
  • Unlike other integrin alpha subunits, the alpha subunit of VLA4 (alpha 4) can appear as a 150-kDa polypeptide (alpha 150), or cleaved into two non-covalently associated polypeptides (alpha 70-80) [34].
  • Furthermore, patient derived T cells actively transmigrated through a collagen IV gel toward medium containing TNF-a, in a process that was inhibited by MAbs to VLA-1 [35].

Analytical, diagnostic and therapeutic context of ITGA1


  1. Differential expression of adhesion molecules in acute leukemia. Reuss-Borst, M.A., Klein, G., Waller, H.D., Müller, C.A. Leukemia (1995) [Pubmed]
  2. Distribution of VLA integrins in solid tumors. Emergence of tumor-type-related expression. Patterns in carcinomas and sarcomas. Miettinen, M., Castello, R., Wayner, E., Schwarting, R. Am. J. Pathol. (1993) [Pubmed]
  3. Crystal structure of the alpha1beta1 integrin I domain in complex with an antibody Fab fragment. Karpusas, M., Ferrant, J., Weinreb, P.H., Carmillo, A., Taylor, F.R., Garber, E.A. J. Mol. Biol. (2003) [Pubmed]
  4. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3. Brooks, P.C., Strömblad, S., Sanders, L.C., von Schalscha, T.L., Aimes, R.T., Stetler-Stevenson, W.G., Quigley, J.P., Cheresh, D.A. Cell (1996) [Pubmed]
  5. Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Brooks, P.C., Montgomery, A.M., Rosenfeld, M., Reisfeld, R.A., Hu, T., Klier, G., Cheresh, D.A. Cell (1994) [Pubmed]
  6. Integrin alpha 2 beta 1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells. Schiro, J.A., Chan, B.M., Roswit, W.T., Kassner, P.D., Pentland, A.P., Hemler, M.E., Eisen, A.Z., Kupper, T.S. Cell (1991) [Pubmed]
  7. Integrin alpha IIb beta 3 mediates binding of the Lyme disease agent Borrelia burgdorferi to human platelets. Coburn, J., Leong, J.M., Erban, J.K. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  8. Specific overproduction of very late antigen 1 integrin in two human neuroblastoma cell lines selected for resistance to detachment by an Arg-Gly-Asp-containing synthetic peptide. Dedhar, S., Haqq, C., Gray, V. J. Biol. Chem. (1989) [Pubmed]
  9. Integrin alpha v beta 3 antagonist Cilengitide enhances efficacy of radiotherapy in endothelial cell and non-small-cell lung cancer models. Albert, J.M., Cao, C., Geng, L., Leavitt, L., Hallahan, D.E., Lu, B. Int. J. Radiat. Oncol. Biol. Phys. (2006) [Pubmed]
  10. Up-regulation of the integrin alpha 1/beta 1 in human neuroblastoma cells differentiated by retinoic acid: correlation with increased neurite outgrowth response to laminin. Rossino, P., Defilippi, P., Silengo, L., Tarone, G. Cell Regul. (1991) [Pubmed]
  11. Integrin alpha1beta1 (VLA-1) mediates adhesion of activated intraepithelial lymphocytes to collagen. Roberts, A.I., Brolin, R.E., Ebert, E.C. Immunology (1999) [Pubmed]
  12. Human smooth muscle VLA-1 integrin: purification, substrate specificity, localization in aorta, and expression during development. Belkin, V.M., Belkin, A.M., Koteliansky, V.E. J. Cell Biol. (1990) [Pubmed]
  13. The membrane-cytoplasm interface of integrin alpha subunits is critical for receptor latency. Briesewitz, R., Kern, A., Smilenov, L.B., David, F.S., Marcantonio, E.E. Mol. Biol. Cell (1996) [Pubmed]
  14. Evidence of T-cell activation and potential cytokine action in human endometrium. Tabibzadeh, S. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
  15. T cell receptor-dependent, antigen-specific stimulation of a murine T cell clone induces a transient, VLA protein-mediated binding to extracellular matrix. Chan, B.M., Wong, J.G., Rao, A., Hemler, M.E. J. Immunol. (1991) [Pubmed]
  16. Beta 1 (CD29) integrin expression in rheumatoid synovial membranes: an immunohistologic study of distribution patterns. el Gabalawy, H., Wilkins, J. J. Rheumatol. (1993) [Pubmed]
  17. Beta-1 integrin cell adhesion molecules in the endometrium of fertile and infertile women. Klentzeris, L.D., Bulmer, J.N., Trejdosiewicz, L.K., Morrison, L., Cooke, I.D. Hum. Reprod. (1993) [Pubmed]
  18. Acquisition and alteration of adhesion molecules during cultured human mast cell differentiation. Tachimoto, H., Hudson, S.A., Bochner, B.S. J. Allergy Clin. Immunol. (2001) [Pubmed]
  19. Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3. Kato, A., Kawamata, N., Tamayose, K., Egashira, M., Miura, R., Fujimura, T., Murayama, K., Oshimi, K. J. Biol. Chem. (2002) [Pubmed]
  20. T cell receptor- and beta 1 integrin-mediated signals synergize to induce tyrosine phosphorylation of focal adhesion kinase (pp125FAK) in human T cells. Maguire, J.E., Danahey, K.M., Burkly, L.C., van Seventer, G.A. J. Exp. Med. (1995) [Pubmed]
  21. The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain. Takada, Y., Hemler, M.E. J. Cell Biol. (1989) [Pubmed]
  22. Endothelial cell integrin laminin receptor expression in multiple sclerosis lesions. Sobel, R.A., Hinojoza, J.R., Maeda, A., Chen, M. Am. J. Pathol. (1998) [Pubmed]
  23. Biochemical characterization of VLA-1 and VLA-2. Cell surface heterodimers on activated T cells. Hemler, M.E., Jacobson, J.G., Strominger, J.L. J. Biol. Chem. (1985) [Pubmed]
  24. Integrin alpha 2 beta 1-dependent EGF receptor activation at cell-cell contact sites. Yu, X., Miyamoto, S., Mekada, E. J. Cell. Sci. (2000) [Pubmed]
  25. Mechanisms of regulation of cell adhesion and motility by insulin receptor substrate-1 in prostate cancer cells. Reiss, K., Wang, J.Y., Romano, G., Tu, X., Peruzzi, F., Baserga, R. Oncogene (2001) [Pubmed]
  26. Binding of Paxillin to the alpha 9 Integrin Cytoplasmic Domain Inhibits Cell Spreading. Liu, S., Slepak, M., Ginsberg, M.H. J. Biol. Chem. (2001) [Pubmed]
  27. Alpha 3 beta 1 integrin is moved into focal contacts in kidney mesangial cells. Grenz, H., Carbonetto, S., Goodman, S.L. J. Cell. Sci. (1993) [Pubmed]
  28. The luminal domain of TGN38 interacts with integrin beta 1 and is involved in its trafficking. Wang, J., Howell, K.E. Traffic (2000) [Pubmed]
  29. Adhesion molecules VLA-1 to VLA-6 define discrete stages of peripheral B lymphocyte development and characterize different types of B cell neoplasia. Möller, P., Eichelmann, A., Koretz, K., Mechtersheimer, G. Leukemia (1992) [Pubmed]
  30. Expression and functions of very late antigen 1 in inflammatory joint diseases. Bank, I., Roth, D., Book, M., Guterman, A., Shnirrer, I., Block, R., Ehrenfeld, M., Langevitz, P., Brenner, H., Pras, M. J. Clin. Immunol. (1991) [Pubmed]
  31. Alpha 4 beta 1 (CD49d/CD29) integrin costimulation of human T cells enhances transcription factor and cytokine induction in the absence of altered sensitivity to anti-CD3 stimulation. Udagawa, T., Woodside, D.G., McIntyre, B.W. J. Immunol. (1996) [Pubmed]
  32. Talin controls the exit of the integrin alpha 5 beta 1 from an early compartment of the secretory pathway. Martel, V., Vignoud, L., Dupé, S., Frachet, P., Block, M.R., Albigès-Rizo, C. J. Cell. Sci. (2000) [Pubmed]
  33. Gene expression profiling of a clonal isolate of oxaliplatin-resistant ovarian carcinoma cell line A2780/C10. Varma, R.R., Hector, S.M., Clark, K., Greco, W.R., Hawthorn, L., Pendyala, L. Oncol. Rep. (2005) [Pubmed]
  34. A single mRNA encodes the alpha 150 and alpha 80/70 forms of the alpha subunit of VLA4. Rubio, M., Nueda, A., Vara, A., Corbí Lopez, A.L. Eur. J. Immunol. (1992) [Pubmed]
  35. Interaction of disease-related antigen-reactive T-cell lines from multiple sclerosis patients with type IV collagen: role of integrin VLA-1 and effects of irradiation. Bank, I., Achiron, A., Levie, G., Koltakov, A., Mandel, M. J. Clin. Immunol. (2002) [Pubmed]
  36. Expression of native and truncated forms of the human integrin alpha 1 subunit. Briesewitz, R., Epstein, M.R., Marcantonio, E.E. J. Biol. Chem. (1993) [Pubmed]
  37. Glanzmann thrombasthenia resulting from a single amino acid substitution between the second and third calcium-binding domains of GPIIb. Role of the GPIIb amino terminus in integrin subunit association. Wilcox, D.A., Paddock, C.M., Lyman, S., Gill, J.C., Newman, P.J. J. Clin. Invest. (1995) [Pubmed]
  38. Use of the monoclonal antibody 12F1 to characterize the differentiation antigen VLA-2. Pischel, K.D., Hemler, M.E., Huang, C., Bluestein, H.G., Woods, V.L. J. Immunol. (1987) [Pubmed]
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