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Gene Review:

FOLR2 - folate receptor 2 (fetal)

Sus scrofa

Van Hoozen, C.M. et al., Villanueva, J. et al., Holm, J. et al., Reisenauer, A.M., Vallet, J.L. et al., et al.

Vallet, Klemcke, Christenson, Vallet, Christenson, Klemcke,

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High impact information on FBP

Although defining the molecular structure of pig liver FBP, these studies suggest that this protein participates in the regulation of folate uptake by liver and kidney membranes but is not involved in folate absorption [1].
Folate-binding protein (FBP) was identified and characterized in a pig liver cDNA library by screening with a 0.6 kb fragment from the cDNA of FBP from a human KB cell cancer line [1].
The cDNA of pig liver FBP included 1230 bp containing 759 bp in the open reading frame with 80% similarity to the human placenta FBP [1].
Folate binding protein: molecular characterization and transcript distribution in pig liver, kidney and jejunum [1].
These results indicate that the intestinal folate-binding and transport proteins are identical and that the function of the folate-binding protein is to transport folate into the cell [2].

Anatomical context of FBP

Subsequent steps in folate absorption include uptake by a brush-border folate-binding-protein receptor and transport across the brush-border membrane into the enterocyte [3].
Identification of 10-formyltetrahydrofolate dehydrogenase-hydrolase as a major folate binding protein in liver cytosol [4].
The IgG fraction of rabbit antibody detected pig recombinant folate binding protein at 30 kDa and stained pig liver plasma membranes and kidney brush-border membranes but did not react with jejunal brush-border membranes [5].

Associations of FBP with chemical compounds

Role of high-affinity folate-binding protein in the plasma distribution of tetrahydrofolate in pigs [6].
The folate analogue N10 methyl folate was a potent and competitive inhibitor of [3H] folate binding to the folate binding protein, and moreover changed the binding type to apparent negative cooperativity [7].

Other interactions of FBP

Number of CL, conceptus number, conceptus diameters, and total uterine flush retinol-binding protein (tRBP), acid phosphatase (tAP), and folate-binding protein (tFBP) were measured [8].
A RIA was developed for porcine intrauterine folate binding protein (FBP) [9].

Analytical, diagnostic and therapeutic context of FBP

A radioimmunoassay for porcine intrauterine folate binding protein [9].

References

Folate binding protein: molecular characterization and transcript distribution in pig liver, kidney and jejunum. Van Hoozen, C.M., Ling, E.H., Halsted, C.H. Biochem. J. (1996) [Pubmed]
Affinity labelling of the folate-binding protein in pig intestine. Reisenauer, A.M. Biochem. J. (1990) [Pubmed]
Jejunal brush-border folate hydrolase. A novel enzyme. Halsted, C.H. West. J. Med. (1991) [Pubmed]
Identification of 10-formyltetrahydrofolate dehydrogenase-hydrolase as a major folate binding protein in liver cytosol. Min, H., Shane, B., Stokstad, E.L. Biochim. Biophys. Acta (1988) [Pubmed]
Membrane and tissue distribution of folate binding protein in pig. Villanueva, J., Ling, E.H., Chandler, C.J., Halsted, C.H. Am. J. Physiol. (1998) [Pubmed]
Role of high-affinity folate-binding protein in the plasma distribution of tetrahydrofolate in pigs. Sasaki, K., Natsuhori, M., Shimoda, M., Saima, Y., Kokue, E. Am. J. Physiol. (1996) [Pubmed]
Characterization of a high affinity folate binding protein in porcine serum: ionic charge, concentration-dependent polymerization and ligand binding mechanism. Holm, J., Hansen, S.I. Biosci. Rep. (2003) [Pubmed]
Interrelationships among conceptus size, uterine protein secretion, fetal erythropoiesis, and uterine capacity. Vallet, J.L., Klemcke, H.G., Christenson, R.K. J. Anim. Sci. (2002) [Pubmed]
A radioimmunoassay for porcine intrauterine folate binding protein. Vallet, J.L., Christenson, R.K., Klemcke, H.G. J. Anim. Sci. (1999) [Pubmed]

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