The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

RBP4  -  retinol binding protein 4, plasma

Sus scrofa

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of RBP4


High impact information on RBP4


Chemical compound and disease context of RBP4


Biological context of RBP4

  • Investigation of the retinol-binding protein 4 (RBP4) gene as a candidate gene for increased litter size in pigs [11].
  • Three diallelic RFLP markers at candidate gene loci for litter size, the estrogen receptor (ESR) gene, the prolactin receptor (PRLR) gene, and the retinol-binding protein 4 (RBP4) gene, were evaluated for their association with the number of piglets born alive in different German pig lines [12].
  • After adjustment for effects of genetic drift, frequency of the two alleles segregating for the FS and RBP4 loci did not differ significantly between lines [13].
  • Porcine conceptus RBP and human serum RBP share 91% amino acid sequence identity [8].
  • Using an oligonucleotide probe corresponding to a highly conserved region of all known mammalian RBP, we have isolated an apparently full-length cDNA clone for porcine conceptus RBP from a cDNA library constructed from pig conceptuses collected between days 13-17 of pregnancy [8].

Anatomical context of RBP4


Associations of RBP4 with chemical compounds

  • Guanidinium chloride-induced unfolding and refolding experiments suggest that the recombinant retinol-binding protein adopts a stable conformation despite being expressed and purified in the absence of the large hydrophobic ligand [1].
  • The objective of this study was to determine how conceptus-derived estrogen might modulate this production of RBP around days 11-13 of pregnancy when conceptuses elongate from spheres to long thread-like forms [2].
  • Detection of transcripts for retinoic acid receptors, retinol-binding protein, and transforming growth factors during rapid trophoblastic elongation in the porcine conceptus [16].
  • Together these findings suggest that 1) the areolar gland subunits are important for transport of retinol and retinol-RBP, and 2) retinoid binding proteins are involved in the development and growth of the porcine placenta [17].
  • Of the various major proteins, clusterin, glutathione peroxidase, retinol-binding protein, lactoferrin, EP4, beta-N-acetyl-hexosaminidase, alpha-mannosidase, and procathepsin L were identified and localized along the organ [18].

Other interactions of RBP4


Analytical, diagnostic and therapeutic context of RBP4


  1. Functional expression of the uncomplexed serum retinol-binding protein in Escherichia coli. Ligand binding and reversible unfolding characteristics. Müller, H.N., Skerra, A. J. Mol. Biol. (1993) [Pubmed]
  2. Steroid regulation of the synthesis and secretion of retinol-binding protein by the uterus of the pig. Trout, W.E., Hall, J.A., Stallings-Mann, M.L., Galvin, J.M., Anthony, R.V., Roberts, R.M. Endocrinology (1992) [Pubmed]
  3. Interactions amongst plasma retinol-binding protein, transthyretin and their ligands: implications in vitamin A homeostasis and transthyretin amyloidosis. Raghu, P., Sivakumar, B. Biochim. Biophys. Acta (2004) [Pubmed]
  4. Homology of beta-lactoglobulin, serum retinol-binding protein, and protein HC. Pervaiz, S., Brew, K. Science (1985) [Pubmed]
  5. Fractional synthesis rates of retinol-binding protein, transthyretin, and a new peptide measured by stable isotope techniques in neonatal pigs. Sivakumar, B., Jahoor, F., Burrin, D.G., Frazer, E.M., Reeds, P.J. J. Biol. Chem. (1994) [Pubmed]
  6. A novel family of progesterone-induced, retinol-binding proteins from uterine secretions of the pig. Clawitter, J., Trout, W.E., Burke, M.G., Araghi, S., Roberts, R.M. J. Biol. Chem. (1990) [Pubmed]
  7. HIV-protease inhibitors alter retinoic acid synthesis. Toma, E., Devost, D., Chow Lan, N., Bhat, P.V. AIDS (2001) [Pubmed]
  8. The retinol-binding protein of the expanding pig blastocyst: molecular cloning and expression in trophectoderm and embryonic disc. Trout, W.E., McDonnell, J.J., Kramer, K.K., Baumbach, G.A., Roberts, R.M. Mol. Endocrinol. (1991) [Pubmed]
  9. Uterine response to progesterone in prepubertal gilts. Groothuis, P.G., Blair, R.M., Simmen, R.C., Vallet, J.L., Grieger, D.M., Davis, D.L. J. Reprod. Fertil. (1997) [Pubmed]
  10. The effect of estrone and estradiol treatment on endometrial total protein, uteroferrin, and retinol-binding protein secretion during midpregnancy or midpseudopregnancy in swine. Vallet, J.L., Christenson, R.K. J. Anim. Sci. (1996) [Pubmed]
  11. Investigation of the retinol-binding protein 4 (RBP4) gene as a candidate gene for increased litter size in pigs. Rothschild, M.F., Messer, L., Day, A., Wales, R., Short, T., Southwood, O., Plastow, G. Mamm. Genome (2000) [Pubmed]
  12. Candidate gene markers for litter size in different German pig lines. Drogemuller, C., Hamann, H., Distl, O. J. Anim. Sci. (2001) [Pubmed]
  13. Characterization of a line of pigs previously selected for increased litter size for RBP4 and follistatin. Blowe, C.D., Boyette, K.E., Ashwell, M.S., Eisen, E.J., Robison, O.W., Cassady, J.P. J. Anim. Breed. Genet. (2006) [Pubmed]
  14. Distribution of vitamin A, retinol-binding protein, cellular retinoic acid-binding protein I, and retinoid X receptor beta in the porcine uterus during early gestation. Schweigert, F.J., Bonitz, K., Siegling, C., Buchholz, I. Biol. Reprod. (1999) [Pubmed]
  15. Association between uteroferrin, retinol-binding protein, and transferrin within the uterine and conceptus compartments during pregnancy in swine. Vallet, J.L., Christenson, R.K., McGuire, W.J. Biol. Reprod. (1996) [Pubmed]
  16. Detection of transcripts for retinoic acid receptors, retinol-binding protein, and transforming growth factors during rapid trophoblastic elongation in the porcine conceptus. Yelich, J.V., Pomp, D., Geisert, R.D. Biol. Reprod. (1997) [Pubmed]
  17. Immunohistochemical localization of retinoid binding proteins at the materno-fetal interface of the porcine epitheliochorial placenta. Johansson, S., Dencker, L., Dantzer, V. Biol. Reprod. (2001) [Pubmed]
  18. Characterization and identification of proteins secreted in the various regions of the adult boar epididymis. Syntin, P., Dacheux, F., Druart, X., Gatti, J.L., Okamura, N., Dacheux, J.L. Biol. Reprod. (1996) [Pubmed]
  19. Uteroferrin induces lipid peroxidation in endometrial and conceptus microsomal membranes and is inhibited by apotransferrin, retinol binding protein, and the uteroferrin-associated proteins. Vallet, J.L. Biol. Reprod. (1995) [Pubmed]
  20. Binding of thyroxine to pig transthyretin, its cDNA structure, and other properties. Duan, W., Richardson, S.J., Köhrle, J., Chang, L., Southwell, B.R., Harms, P.J., Brack, C.M., Pettersson, T.M., Schreiber, G. Eur. J. Biochem. (1995) [Pubmed]
  21. Effect of treatment with retinyl palmitate, progesterone, oestradiol and tamoxifen on secretion of a protein similar to retinol-binding protein during uterine gland development in neonatal pigs. Vallet, J.L., Christenson, R.K., Bartol, F.F., Wiley, A.A. J. Reprod. Fertil. (1995) [Pubmed]
WikiGenes - Universities