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Gene Review

GOT1  -  glutamic-oxaloacetic transaminase 1,...

Sus scrofa

Synonyms: CASPAT, cCAT
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Disease relevance of CASPAT


High impact information on CASPAT


Biological context of CASPAT


Anatomical context of CASPAT

  • It was found that, in the rat heart muscle, c-AAT reaction product was present as a linear structure parallel to the muscle fiber and along the sarcolemma [9].
  • Under the same experimental conditions, the c-AAT was localized in each individual hepatocyte by both monoclonal and polyclonal antibodies [10].
  • The rabbit antiserum and mouse monoclonal hybridoma antibody against porcine cytosolic aspartate aminotransferase (c-AAT) (or cytosolic glutamic oxaloacetic transaminase (c-GOT)) were produced and compared for the localization of c-AAT in rat liver [10].

Associations of CASPAT with chemical compounds


Other interactions of CASPAT


Analytical, diagnostic and therapeutic context of CASPAT


  1. cDNA cloning and expression of pig cytosolic aspartate aminotransferase in Escherichia coli: amino-terminal heterogeneity of expressed products and lack of its correlation with enzyme function. Nagashima, F., Tanase, S., Fukumoto, Y., Joh, T., Nomiyama, H., Tsuzuki, T., Shimada, K., Kuramitsu, S., Kagamiyama, H., Morino, Y. Biochemistry (1989) [Pubmed]
  2. The molecular structure of hyperthermostable aromatic aminotransferase with novel substrate specificity from Pyrococcus horikoshii. Matsui, I., Matsui, E., Sakai, Y., Kikuchi, H., Kawarabayasi, Y., Ura, H., Kawaguchi, S., Kuramitsu, S., Harata, K. J. Biol. Chem. (2000) [Pubmed]
  3. Functional role of the amino-terminal mobile segment in catalysis by porcine cytosolic aspartate aminotransferase. Critical importance of Val17 and Phe18 for productive binding of substrates. Nishimura, K., Higaki, T., Okamura, H., Tanase, S. J. Biol. Chem. (1994) [Pubmed]
  4. Functional roles of valine 37 and glycine 38 in the mobile loop of porcine cytosolic aspartate aminotransferase. Pan, Q.W., Tanase, S., Fukumoto, Y., Nagashima, F., Rhee, S., Rogers, P.H., Arnone, A., Morino, Y. J. Biol. Chem. (1993) [Pubmed]
  5. Identification of coenzyme aldimine proton in 1H NMR spectra of pyridoxal 5'-phosphate dependent enzymes: aspartate aminotransferase isoenzymes. Morino, Y., Nagashima, F., Tanase, S., Yamasaki, M., Higaki, T. Biochemistry (1986) [Pubmed]
  6. Studies of 6-fluoropyridoxal and 6-fluoropyridoxamine 5'-phosphates in cytosolic aspartate aminotransferase. Scott, R.D., Chang, Y.C., Graves, D.J., Metzler, D.E. Biochemistry (1985) [Pubmed]
  7. Non-enzymatic glycosylation (or glycation) and inhibition of the pig heart cytosolic aspartate aminotransferase by glyceraldehyde 3-phosphate. Fitzgerald, C., Swearengin, T.A., Yeargans, G., McWhorter, D., Cucchetti, B., Seidler, N.W. J. Enzym. Inhib. (2000) [Pubmed]
  8. Partial amino-acid sequence and cysteine reactivities of cytosolic aspartate aminotransferase from horse heart. Martini, F., Angelaccio, S., Barra, D., Doonan, S., Bossa, F. Biochim. Biophys. Acta (1984) [Pubmed]
  9. Production and characterization of an antibody to cytosolic aspartate aminotransferase and immunolocalization of the enzyme in rat organs. Lin, C.T., Chen, L.H. Lab. Invest. (1983) [Pubmed]
  10. A comparative study of polyclonal and monoclonal antibodies for immunocytochemical localization of cytosolic aspartate aminotransferase in rat liver. Lin, C.T., Chen, L.H., Chan, T.S. J. Histochem. Cytochem. (1983) [Pubmed]
  11. Covalently modified peptides isolated from aspartate aminotransferase after reaction with pyridoxal 5'-sulfate. Schmidt, J., Scott, R.D., Metzler, D.E. Biochemistry (1982) [Pubmed]
  12. Inactivation of cytosolic aspartate aminotransferase accompanying modification of Trp 48 by N-bromosuccinimide. Nagashima, F., Tanase, S., Morino, Y. FEBS Lett. (1986) [Pubmed]
  13. Carnosine promotes the heat denaturation of glycated protein. Yeargans, G.S., Seidler, N.W. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  14. Synthesis of 3-arsonoalanine and its action on aspartate aminotransferase and aspartate ammonia-lyase. Comparison with arsenical analogues of malate and fumarate. Ali, B.R., Dixon, H.B. Eur. J. Biochem. (1993) [Pubmed]
  15. Limited proteolysis as a probe of conformational changes in aspartate aminotransferase from Sulfolobus solfataricus. Arnone, M.I., Birolo, L., Giamberini, M., Cubellis, M.V., Nitti, G., Sannia, G., Marino, G. Eur. J. Biochem. (1992) [Pubmed]
  16. Multiple forms of aspartate aminotransferase as studied by liquid chromatography. Soronen, R., Korpela, T. Prog. Clin. Biol. Res. (1984) [Pubmed]
  17. Acrolein modifies and inhibits cytosolic aspartate aminotransferase. Southwell, J.L., Yeargans, G.S., Kowalewski, C., Seidler, N.W. Journal of enzyme inhibition and medicinal chemistry. (2002) [Pubmed]
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